基于IP的医院信息系统存储策略

分析了医院存储系统特点，在比较现有各种存储技术的基础上，提出了基于IP的网络存储策略。     

Larynx preservation surgery in pyriform sinus cancer

As a general rule, surgery, whenever possible followed by irradiation, is considered to be a standard treatment for pyriform sinus cancer. In early primary lesions, many different approaches have been tried for larynx preservation. From 1990-1997, 7 patients with pyriform sinus carcinoma without the involvement of pyriform sinus apex were treated with partial laryngopharyngectomy at the Asan Medical Center. Three patients were T1 stage and four were T2. All patients had nodal metastases and were treated with neck dissection and postoperative radiotherapy. Follow-up period was 1-8 years. One regional recurrence and one distant metastasis occurred; however, there was no recurrence at the primary site. The voices of all the patients were saved. The most uncomfortable postoperative symptom was mild aspiration. From these results, we can conclude that partial laryngopharyngectomy with neck dissection might be the favorable treatment modality for selected cases of pyriform sinus cancer.     

Malignant transformation of nevus sebaceous to basal-cell carcinoma: Case series,literature review,and management algorithm

Nevus sebaceous (NS) is a common congenital hamartoma of the skin composed predominantly of sebaceous glands. Although most NS are benign skin tumors, malignant transformations have been reported. There is still controversy about the lifetime risk of malignant degeneration and precise surgical criteria. This study reports cases of malignant degeneration and suggests a surgical treatment algorithm. The medical records of patients with basal-cell carcinoma (BCC) arising from NS between January 2001 and January 2021 were retrospectively reviewed. Patient demographics including lesion location, and tumor size were investigated. The symptoms, histological findings before and after excision, complications, and recurrence during 2-year follow-up periods were investigated. Ten patients were identified with BCC arising from NS lesions. All patients were female and the mean age was 52.11 years. All patients complained of sudden morphological changes, the most common type being rapid color changes. Two cases had histological findings that showed a miss-match between punch biopsy and excisional biopsy results. No recurrence was detected 2 years after surgeries in any patients. Cases after third stage, especially in over 40 years who report morphologic changes, should undergo total surgical excision as the first approach, with strong suspicion of malignant degeneration.     

Ⅳ度旋后外旋型踝关节损伤的手术治疗

目的探讨Ⅳ度旋后外旋型踝关节损伤的手术疗效。方法对41例Ⅳ度旋后外旋型踝关节损伤患者依据X线及CT扫描急诊行切开复位内固定治疗,术后石膏功能位外固定。结果41例均获随访,时间13～53个月,平均18个月。AOFAS踝-后足评分,90～100分37例,80～90分4例,患者均恢复日常生活工作,踝关节无疼痛。结论强调Ⅳ度旋后外旋型踝关节损伤的早期正确诊断,早期手术治疗,才能重建稳定的踝关节。     

舌黏膜尿道成形治疗尿道狭窄的初步报告

目的:探讨舌黏膜补片法尿道成形治疗尿道狭窄的疗效。方法:采用舌黏膜尿道成形治疗尿道狭窄14例。尿道狭窄段3.5~14cm,平均6.2cm;术前耻骨上膀胱造瘘8例,余6例排尿均较为困难,最大尿流率2.5~5.5ml/s,平均3.8ml/s。结果:术后随访2~8个月,1例因伤口感染致尿道皮肤瘘,余患者均排尿通畅,最大尿流率增至22~51ml/s,平均29.6ml/s。结论:舌黏膜具有取材方便、对患者创伤小、抗感染力强等特点,是一种较好的尿道替代物,尤其适合尿道狭窄段<6cm的患者。     

The Alleviation of Gut Microbiota-Induced Depression and Colitis in Mice by Anti-Inflammatory Probiotics NK151, NK173, and NK175

Gut microbiota dysbiosis is strongly associated with psychiatric disorders and inflammatory bowel disease (IBD). Herein, we examined whether the fecal microbiota of IBD patients with depression (IBDD) and their gut microbiota culture (iGm) could cause depression and colitis in mice and anti-inflammatory probiotics could mitigate depression in iGm-transplanted or immobilization stress (IS)-exposed mice. Fecal microbiota transplantation (FMT) from IBDD patients, which exhibited Enterobacteriaceae-rich gut microbiota, and its gut microbiota culture (iGm) increased depression-like behaviors in mice. Their treatments heightened the blood lipopolysaccharide (LPS) level and colonic IL-1β and IL-6 expression. However, FMT from healthy volunteers or sulfasalazine treatment alleviated cGm-induced depressive-like behaviors and hippocampal and colonic inflammation in mice. Moreover, oral administration of Lactobacillus plantarum NK151, Bifidobacterium longum NK173, and Bifidobacterium bifidum NK175, which inhibited LPS-induced IL-6 expression in macrophages, alleviated cGm-induced depression-like behaviors, hippocampal NF-κB⁺Iba1⁺ cell numbers and IL-1β and IL-6 expression, blood LPS, IL-6, and creatinine levels, and colonic NF-κB⁺CD11c⁺ number and IL-1β and IL-6 expression in mice. Treatment with NK151, NK173, or NK175 mitigated immobilization stress (IS)-induced depressive-like behaviors, neuroinflammation, and gut inflammation in mice. NK151, NK173, or NK175 also decreased IS-induced blood LPS, IL-6, and creatinine levels. The transplantation of Enterobacteriaceae-rich gut microbiota can cause depression and colitis, as IS exposure, and anti-inflammatory NK151, NK173, and NK175, may alleviate stress-induced fatigue, depression, and colitis by regulating the expression of proinflammatory and anti-inflammatory cytokines through the suppression of gut bacterial LPS.     

术中结肠灌洗在左半大肠癌并急性肠梗阻Ⅰ期切除吻合中的研究

目的探讨术中结肠灌洗在左半大肠癌并急性肠梗阻Ⅰ期切除吻合中的应用价值。方法对我科2006年收治86例左半结肠癌并急性肠梗阻Ⅰ期切除吻合进行回顾性分析。根据术中采用不同的肠道准备方法,86例患者被随机分为全结肠灌洗组(39组)及单纯肠道减压组(47例)。结果全结肠灌洗组并发症发生6例,发生率15.4%,死亡1例,死亡率2.6%。单纯肠道减压组发症发生8例,发生率17.0%,死亡2例,死亡率4.3%。非灌洗组和灌洗组并发症发生率两者间差异无统计学意义(P=0.838)。结论左半大肠癌并急性肠梗阻Ⅰ期切除吻合是安全可靠的,疗效满意。不同术中肠道准备不是影响治疗效果的关键,不灌洗肠腔是可行的。     

维药胡桐泪的多糖含量测定及其糖组成分析

目的:测定市场上实际流通的商品胡桐泪药材中多糖的含量并对其单糖组成进行分析,以多糖为指标评价药材质量。方法:采用苯酚-硫酸法对总多糖进行含量测定;应用核磁共振氢谱(1H-NMR)分析单糖组成;运用高效凝胶渗透色谱(HPGPC)测定总多糖的分子量分布。结果:以葡萄糖计,4批新式胡桐泪总多糖含量平均值为(7.36±1.74)%,6批老式胡桐泪总多糖含量平均值为(1.53±0.99)%;新式与老式胡桐泪总多糖的单糖组成相似,主要由阿拉伯糖和半乳糖组成,还含有木糖、甘露糖、鼠李糖等,部分样品尚含有较高含量的葡萄糖;新旧类型样品总多糖在分子量分布上存在较大差异。结论:新式胡桐泪的总多糖含量平均值较老式高,以多糖含量为评价指标时,新式样品总体质量较老式更好;应用核磁共振氢谱可以快速、准确地鉴定单糖组成。     

伊藤痣上继发色素减退斑1例

报告1例伊藤痣上继发色素减退斑。患者女,43岁。7个月前原左颈肩区先天性蓝色斑片中开始出现色素改变：自后体表正中线向左,呈瓷白色、天蓝色及黄蓝色逐渐改变。天蓝色皮损组织病理检查示：表皮基底层黑素细胞消失．真皮浅层及中层少量梭形黑素细胞及较多形态各异的载色素细胞。表皮轻度海绵形成、角化不全、角质形成细胞局灶性坏死及基底层空泡变性。表、真皮交界处淋巴细胞浸润。诊断为继发于伊藤痣上的晕痣（halonevus）和晕皮炎（halo dermatitis）。     

一点红属植物化学成分和药理作用研究进展

对一点红属植物的化学成分和药理作用的研究进展进行介绍,为进一步研究和开发利用提供参考.检索国内外CNKI,Mediline,CA等数据库,收集近年来有关一点红属植物的化学成分和药理作用研究的文献资料36篇,并对其进行整理、分析.一点红属植物的主要化学成分为生物碱、黄酮、挥发油等化合物,具有抗肿瘤、抗炎镇痛、抗氧化、抗糖尿病等药理作用.一点红属植物在抗肿瘤、抗炎方面有着广阔的应用前景,建议加强其物质基础研究.该属植物含有吡咯里西啶类有毒生物碱,需加强毒理学研究,为安全性用药提供依据.