联合内分泌治疗对前列腺和睾丸的影响

目的 探讨抑那通和缓退瘤联合治疗对正常前列腺,增生的前列腺（ＢＰＨ）和前列腺癌以及睾丸的作用。方法 对１６例接受联合内分泌治疗至少３个月且有治疗前后病理资料的前列腺癌患者的标本进行了系统的病理学检查。对内分泌治疗后的睾丸标本与同龄未接受治疗的进行对照研究。结果 １４例内分泌治疗后的前列腺标本２例未见残存癌灶,９例对治疗有明显的反应;３例对治疗反应差,治疗并未降低前列腺癌的病理分期。３例内分泌治疗后     

基于Windows的S12数字程控交换机人机命令查询系统的设计与实现

介绍了基于Windows3.x环境下,用Delphi开发软件,结合面象对象技术、数据库技术、Windows帮助文件系统技术,开发S12数字程控交换机人机命令信息查询系统的过程和方法.并对超文本技术、面向对象技术、数据库技术进行了阐述.通过试运行,验证了本系统的高速、方便、安全、兼容性好等特点.     

基于应用软件平台的医疗保险信息系统的分析与实现

介绍了应用软件平台的应用背景--管理信息系统的模型,在此基础上推导出了应用软件平台的定义,描述了应用软件平台的结构.提出了应用软件平台的具体应用项目--医疗保险信息系统,阐述了医疗保险的基本概念,用管理信息系统的4元组描述法提出了医疗保险信息系统的模型.概述了该应用系统中的应用软件平台的组成和结构,以及系统的特点和实施结果.     

4个铁路区段提速列车噪声影响调查

为探讨提速列车噪声对铁路两侧环境及居民健康影响,依据声源,环境噪声等固定标准,对４个铁路运行区段进行了调查。     

The muscular vascular index. Analysis of the vascularization of the muscles of the forearm]

The results of an anatomic study based on 50 fresh adult cadaver upper extremities are analysed. All the arterial pedicles of each forearm muscle were counted, and each muscle was weighed. Each forearm contained an average number of 264 muscular pedicles. The relative mass fraction of each muscle was calculated, as was its "muscular vascular index" or MVI (number of pedicles divided by the weight of the muscle in grams). Half of the forearm muscles had a significant statistical relationship between their weight and their number of vascular pedicles. The other half had no statistical relationship. These two statistical muscular groups (with and without a statistical relationship) did not clearly correspond to anatomic or functional groups. No muscular group based on the average of MVI was found. Each of the 20 forearm muscle had finally its own characteristics of weight, number of pedicles, and MVI. The average MVI was 0.9 (from 0.4 to 1.8). The global muscular vascular index (GMVI) is the division of the total number of muscular pedicles of a forearm by the total muscular weight of this forearm. The average GMVI was 0.8 (from 0.4 to 1.6). In spite of its theoretical and practical limits, the MVI concept approximately reflects the high vascular density of the forearm muscles.     

三种细菌生物被膜中超广谱β-内酰胺酶的检测

目的检测肺炎克雷伯氏菌、大肠埃希氏菌、铜绿假单胞菌三种细菌的生物被膜(biofilm,BF)中超广谱β-内酰胺酶(Extended-spectrumβ-lactamases,ESBLs)的产生。方法用改良平板培养法在硅胶膜上建立肺炎克雷伯氏菌、大肠埃希氏菌、铜绿假单胞菌BF的体外模型。用银染法及扫描电镜对BF进行鉴定。用双纸片试验检测ESBLs,等电聚焦电泳测定β-内酰胺酶的等电点。结果三种细菌的各30株中,BF肺炎克雷伯氏菌组(A2组)中ESBLs的产生率最高(14株,46.7%),其浮游菌组(A1组)检出8株(26.7%);BF大肠埃希氏菌组(B2组)有10株(33.3%)产生ESBLs,其浮游菌组(B1组)检出6株(20.0%);BF铜绿假单胞菌组(C2组)有3株(10%)产ESBLs,其浮游组(C1组)为2株(6.7%)。浮游菌组中ESBLs的产生率低于BF菌组,其中肺炎克雷伯氏菌及大肠埃希氏菌的BF组和浮游菌组的检出率之间有显著差异(P<0.05)。A2组共检出14株产生ESBLs,有4种ESBLs,等电点分别为8.2(4株)、7.6(8株)、6.3(1株)和5.6(1株),A1组检出8株产生ESBLs,为3种ESBLs,等电点分别为8.2(2株)、7.6(5株)和5.6(1株);B2、B1组检出2种相同等电点分别为7.6(B1组4株,B2组6株)、8.2(B1组2株,B2组4株)的ESBLs;C1、C2组检出一种等电点为6.4的ESBLs(C1组2株,C2组3株)。以pI为7.6的β-内酰胺酶的检出率最高,其     

地塞米松体外诱导宫颈癌细胞株凋亡及其机制的研究

目的 :研究地塞米松 (Dex)体外能否诱导宫颈癌细胞株 (HeLa细胞 )发生凋亡及其机制。方法 :采用透射电镜、DNALadder、流式细胞仪等方法进行凋亡检测 ,用ECLWesternblot方法检测凋亡过程中相关基因表达的变化。结果 :地塞米松体外作用于HeLa细胞后 ,透射电镜观察到了凋亡小体 ;DNALadder法也检测到了凋亡时DNA降解形成的梯带 ;流式细胞仪检测到了细胞凋亡峰 ,且峰值随着处理时间的延长而增高。在凋亡过程中 ,凋亡相关基因bcl 2表达下调 ,而p5 3基因表达无明显改变。结论 :地塞米松体外能诱导HeLa细胞发生凋亡 ,其机制与bcl 2基因的表达下调有关     

Radio frequency transmyocardial revascularization enhances angiogenesis and causes myocardial denervation in canine model

BACKGROUND AND OBJECTIVE: Transmyocardial revascularization (TMR) relieves angina and improves exercise tolerance in patients. Angiogenesis and myocardial denervation have been proposed as factors contributing to these benefits. To test whether radio frequency transmyocardial revascularization (RF-TMR) enhances angiogenesis and causes myocardial denervation. STUDY DESIGN/MATERIALS AND METHODS: RF-TMR channels were created in 12 dogs which survived up to 4 weeks. Bromodeoxyuridine was administered subcutaneously to mark proliferating cells as an assay of angiogenesis. Western blot analysis of tyrosine hydroxylase and blood pressure response to topical bradykinin were used as indices of myocardial denervation. RESULTS: RF-TMR increased local vascularity by an average of 50%, whereas the rate of vascular cell proliferation was tripled over that of the untreated region. Changes in mean arterial pressure with bradykinin and tyrosine hydroxylase content were significantly decreased in RF-TMR regions as compared with normal myocardium in the same hearts. CONCLUSION: RF-TMR enhances angiogenesis and causes myocardial denervation in canine myocardium as with laser TMR.     

Cardiac anomalies in chronic renal failure

PRINCIPAL CARDIOVASCULAR COMPLICATIONS IN END STAGE RENAL DISEASE: Cardiovascular diseases are the leading causes of morbidity and mortality in end stage renal disease patients. Very often, complications observed are left ventricular hypertrophy and various forms of arterial degenerative lesions involving coronary arteries, less frequently pericarditis and calcifying valvulopathy are diagnosed. THE REASONS ARE COMPLEX: Risk factors can be either specific of uremia per se such as anemia, overhydration, fistula or the same as in the general population. Hemodynamic alterations including tensile stress or blood flow play a major role associated to various locally or generally generated substances whose role remains currently to be determined. THEIR TREATMENTS: Treatments of cardiovascular complications are not specific in this end stage renal disease population but are more often the treatment of the etiology: reduction of fistula blood flow, increase of hemoglobin, best control of weight gain between two hemodialysis sessions or blood pressure control.