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排序方式: 共有677条查询结果,搜索用时 78 毫秒
671.
672.
Okiura T Nagatomo F Gu N Taguchi Y Morimatsu F Ishihara A 《The journal of physiological sciences : JPS》2008,58(4):221-227
Femur bone densities and tibialis anterior muscle properties of type II collagen-induced arthritic mice were determined. Furthermore, voluntary running activities of arthritic mice were compared with those of controls. Arthritis was induced by an intradermal injection of type II collagen in the adjuvant. Body and muscle weights were lower in arthritic mice than in controls. Cortical and trabecular bone densities and muscle fiber cross-sectional areas were decreased by arthritis. After classifying the arthritic severity into slight, intermediate, and severe levels based on the degree of knuckle swelling, cortical and trabecular bone densities, fiber cross-sectional areas, and fiber succinate dehydrogenase activities were lowest when arthritis was most severe. Furthermore, arthritic mice, especially those with intermediate and severe levels, showed lower voluntary running activities. These findings indicate that lower bone density and muscle atrophy of type II collagen-induced arthritic mice are related to arthritic severity and decreased motor activity. 相似文献
673.
Akira Nakao Osamu Hiranuma Junji Uchino Chikara Sakaguchi Toshiyuki Kita Noriya Hiraoka Tamotsu Ishizuka Yutaka Kubota Masayuki Kawasaki Yasuhiro Goto Hisao Imai Noboru Hattori Keita Nakatomi Hidetaka Uramoto Kiyoaki Uryu Minoru Fukuda Yasuki Uchida Toshihide Yokoyama Masaya Akai Tadashi Mio Seiji Nagashima Yusuke Chihara Nobuyo Tamiya Yoshiko Kaneko Takako Mouri Tadaaki Yamada Kenichi Yoshimura Masaki Fujita Koichi Takayama 《The oncologist》2019,24(5):593-e170
674.
Akihisa Kato Itaru Naitoh Hiroyuki Kato Kazuki Hayashi Katsuyuki Miyabe Michihiro Yoshida Yasuki Hori Makoto Natsume Naruomi Jinno Takeshi Yanagita Shuji Takiguchi Satoru Takahashi Takashi Joh 《World journal of gastrointestinal oncology》2018,10(3):91-95
Endoscopic transpapillary brush cytology and forceps biopsy during endoscopic retrograde cholangiopancreatology are generally used to obtain pathological evidence of biliary strictures. Recently, the new endoscopic scraper Trefle® has been reported and demonstrated high cancer detectability in malignant biliary strictures. This device is used to scrape the stricture over the guidewire, and, in the original method, the tissue and/or cell samples obtained are subjected to histological and/or cytological analysis separately. However, discrimination of chunks of tissue is hampered by the opacity of the surrounding fluid. We have developed a cell block technique for the Trefle® device without dividing obtained specimens into tissue and cellular components, which is the simplest method and enables immunohistochemical analysis. We present a case of obstructive jaundice diagnosed immunohistochemically as pancreatic metastasis from colon cancer using cell block sections obtained with the Trefle® device, which procedure is as easy as conventional brush cytology. 相似文献
675.
Hiroshi Kurosaka Sayuri Yamamoto Kyoko Hirasawa Tomoe Yanagishita Kaoru Fujioka Hideaki Yagasaki Miho Nagata Yasuki Ishihara Ayumi Yonei Yoshihiro Asano Namiki Nagata Takayuki Tsujimoto Toshihiro Inubushi Toshiyuki Yamamoto Norio Sakai Takashi Yamashiro 《American journal of medical genetics. Part A》2023,191(7):1984-1989
Craniofacial defects are one of the most frequent phenotypes in syndromic diseases. More than 30% of syndromic diseases are associated with craniofacial defects, which are important for the precise diagnosis of systemic diseases. Special AT-rich sequence-binding protein 2 (SATB2)-associated syndrome (SAS) is a rare syndromic disease associated with a wide variety of phenotypes, including intellectual disability and craniofacial defects. Among them, dental anomalies are the most frequently observed phenotype and thus becomes an important diagnostic criterion for SAS. In this report, we demonstrate three Japanese cases of genetically diagnosed SAS with detailed craniofacial phenotypes. The cases showed multiple dental problems, which have been previously reported to be linked to SAS, including abnormal crown morphologies and pulp stones. One case showed a characteristic enamel pearl at the root furcation. These phenotypes add new insights for differentiating SAS from other disorders. 相似文献
676.
677.
Michihiro Yoshida Hiroshi Yukawa Kazuki Hayashi Itaru Naitoh Katsuyuki Miyabe Yasuki Hori Makoto Natsume Naruomi Jinno Akihisa Kato Kenta Kachi Go Asano Hidenori Sahashi Tadashi Toyohara Kayoko Kuno Yusuke Kito Hiromu Kondo Atsuyuki Hirano Fumihiro Okumura Kaiki Anbe Yoshinobu Baba Hiromi Kataoka Yasuhito Tanaka 《Cancer science》2023,114(1):295-305
Sampling of bile juice during endoscopic retrograde cholangiopancreatography (ERCP) has potential benefit of being amenable to the identification of novel biomarkers in liquid biopsy. This study reports the results of a global investigation of exosomal microRNAs (miRNAs) in bile to identify potential biomarkers for biliary tract cancers (BTCs). Eighty-eight bile samples collected during ERCP (45 BTC and 43 noncancer control samples) were enrolled in this study. Eleven BTC samples and nine control samples were assigned as the discovery set. Exosomes in bile and serum samples were collected using a glass membrane column with size-controlled macroporous glass (MPG), and exosomal miRNA expression profiles were evaluated using comprehensive miRNA microarray analysis (3D-Gene). For validation, exosomal miRNA in the bile samples of 34 BTCs and 34 controls were comprehensively evaluated using 3D-Gene. In the discovery set, eight exosomal miRNAs in bile were identified as significant aberrant expression markers, while no miRNA with aberrant expression in serum was identified. In a comparison of the discovery and validation sets, miR-451a and miR-3619-3p were identified as reproducible upregulated markers, and the combination of the two bile miRNAs showed an excellent area under the curve (0.819) value for diagnosing BTCs. In addition, high miR-3619-3p expression in bile reflects poorer prognosis of BTCs (hazard ratio = 2.89). The MPG-extracted exosomal miRNAs in bile aspirated during ERCP provide a convenient new approach for diagnosing biliary diseases. Bile-derived miRNA analysis with miR-451a and miR-3619-3p represents a potentially valuable diagnostic strategy for identifying BTCs as well as a predictive indicator of BTC prognosis. 相似文献