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151.
Alexandre Thobie Andrea Mulliri Nathan Dolet Yassine Eid Véronique Bouvier Guy Launoy Arnaud Alves Olivier Dejardin 《Surgical oncology》2018,27(4):759-766
Background
Survival of patients with pancreatic adenocarcinoma (PA) is very poor. Resection status is highly associated with prognosis but only 15%–20% are resectable. The aim of this study was to analyse the impact of socioeconomic deprivation on PA survival and to define which management steps are affected.Methods
Between 01/01/2000 and 31/12/2014, 1451 incident cases of PA recorded in the digestive cancer registry of the French department of Calvados were included. The population was divided between less deprived areas (quintile 1) and more deprived areas (quintile 2,3,4,5 aggregated).Results
Patients from less deprived areas were younger at diagnosis than those from more deprived areas (69.9 vs 72.3 years, p?=?0.01). There was no difference in stage or comorbidities. Three- and 5-year survival rates were significantly higher for less deprived areas than more deprived areas: 10.5% vs 5.15% and 4.7% vs 1.7% respectively (p?=?0.01). In univariate analysis, those living in less deprived areas had a better survival than those in more deprived areas (HR?=?0.81 [0.69–0.95], p?=?0.009) but not in multivariable analysis (HRa?=?0.93 [0.79–1.11], p?=?0.383) or analysis stratified on resection. In multivariable regression, less deprived areas had more access to surgery than more deprived areas (ORa?=?1.73 [1.08–2.47], p?=?0.013). No difference was observed on access to adjuvant chemotherapy (ORa?=?0.95 [0.38–2.34], p?=?0.681).Conclusion
The key to reducing survival inequalities in PA is access to resection, so future studies should investigate the factors impacting this issue. 相似文献152.
Afef Béjaoui Issam Ben Salem Nesrine Rokbeni Yassine M’rabet Mohamed Boussaid Abdennacer Boulila 《Pharmaceutical biology》2017,55(1):906-911
Context: Natural products are reported to have a wide spectrum of pharmacological properties such as antimicrobial, anti-inflammatory and anti-cholinesterase. The genus Hypericum (Hypericaceae) is a source of a variety of molecules with different biological activities, notably hypericin and various phenolics.Objectives: The goals of the present work were the determination of total phenolic and flavonoid content, hypericin and hyperforin concentration as well as the evaluation of biological of Hypericum humifusum L. (Hhu) and Hypericum perfoliatum L. (Hper).Materials and methods: The various extracts of aerial parts were powdered, and then extracted with methanol. Antibacterial activity was performed according to minimum inhibitory concentration (MIC) and minimum bactericidal (MBC) methods against four Gram-positive bacteria, four Gram-negative bacteria and yeast.Results: The results revealed that H. humifusum, bear the highest total phenolic and flavonoid content (48–113?mg GAE/g and 8–41?mg RE/g, respectively) as well as hypericin (60–90?mg/g) and hyperforin (8–30?mg/g) concentration. Both species showed significant antioxidant activity as revealed by DPPH, FRAP, ABTS, and metal chelating assays. H. humifusum exhibited a strong acetylcholinesterase (3.86–4.57?mg GALAEs/g), α-glucosidase (0.73–2.55?mmol ACEs/g) and α-amylase (3–8?mmol ACEs/g) inhibitory activity. The extract of H. humifusum exhibited strong antibacterial activity mainly against Staphylococcus epidermidis, Staphylococus aureus, and Enterococcus faecium (MIC values ranging from 200 to 250?μg/mL). The highest antifungal activity was showed for H. perfoliatum extract (MIC value = 250?μg/mL).Conclusion: The data suggest that H. humifusum could be used as valuable new natural agents with functional properties for pharmacology industries. 相似文献
153.
The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers
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154.
155.
Abduh Elbanna Mohammed Tag Eldin Mohammad Fathy Osama Osman Mohammed Abdelfattah Abdelrahman Safwat Mohammed Sedki Abd Elkader Shymaa E. Bilasy Khaled salama Asim A. Elnour Abdullah Shehab Shazly Baghdady Mohamed Amer Mohamed Alboraie Aly ragb Abd Elrazek Abd Elrazek 《Medicine》2015,94(49)
Children obesity has become one of the most important public health problems in many countries worldwide. Although the awareness of childhood obesity as a modifiable health risk is high, but many societies do not prioritize this issue as a health care problem, which may lead to comorbidities and even premature death. Despite the rising interest in bariatric surgery for children, only laparoscopic sleeve gastrectomy (LSG) is being considered in resolving childhood obesity who failed other dietary or drug therapies; however many of LSG procedures failed to reduce the weight in children or resulted in complications postsurgery.Here, we present a novel bariatric procedure to clue out a female child 13 years old presented with Legg–Calvé–Perthes disease-associated morbid obesity. The surgical bariatric technique applied both fundal resection and surgical bypass in pediatric obesity using the Elbanna novel bariatric technique.Bariatric surgical bypass may be considered in complicated-childhood cases who failed all other options. 相似文献
156.
Madiha Bou Ali Yassine Ben Ali Aida Karray Ahmed Fendri Youssef Gargouri 《Lipids in health and disease》2011,10(1):24
Background
The turkey pancreatic lipase (TPL) was purified from delipidated pancreases. Some biochemical properties and kinetic studies were determined using emulsified system and monomolecular film techniques. Those studies have shown that despite the accumulation of free fatty acids at the olive oil/water interface, TPL continues to hydrolyse efficiently the olive oil and the TC4 in the absence of colipase and bile salts, contrary to most classical digestive lipases which denaturate rapidly under the same conditions. The aim of the present study was to express TPL in the methylotrophic yeast Pichia pastoris in order to get a large amount of this enzyme exhibiting interesting biochemical properties, to purify and characterize the recombinant enzyme. 相似文献157.
158.
The membrane-spanning part of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel comprises 12 transmembrane (TM) α-helices, arranged into two pseudo-symmetrical groups of six. While TM6 in the N-terminal
TMs is known to line the pore and to make an important contribution to channel properties, much less is known about its C-terminal
counterpart, TM12. We have used patch clamp recording to investigate the accessibility of cytoplasmically applied cysteine-reactive
reagents to cysteines introduced along the length of TM12 in a cysteine-less variant of CFTR. We find that methanethiosulfonate
(MTS) reagents irreversibly modify cysteines substituted for TM12 residues N1138, M1140, S1141, T1142, Q1144, W1145, V1147,
N1148, and S1149 when applied to the cytoplasmic side of open channels. Cysteines sensitive to internal MTS reagents were
not modified by extracellular [2-(trimethylammonium)ethyl] MTS, consistent with MTS reagent impermeability. Both S1141C and
T1142C could be modified by intracellular [2-sulfonatoethyl] MTS prior to channel activation; however, N1138C and M1140C,
located deeper into the pore from its cytoplasmic end, were modified only after channel activation. Comparison of these results
with previous work on CFTR-TM6 allows us to develop a model of the relative positions, functional contributions, and alignment
of these two important TMs lining the CFTR pore. We also propose a mechanism by which these seemingly structurally symmetrical
TMs make asymmetric contributions to the functional properties of the channel pore. 相似文献
159.