全文获取类型
收费全文 | 2971篇 |
免费 | 121篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 179篇 |
妇产科学 | 137篇 |
基础医学 | 200篇 |
口腔科学 | 91篇 |
临床医学 | 269篇 |
内科学 | 688篇 |
皮肤病学 | 63篇 |
神经病学 | 171篇 |
特种医学 | 138篇 |
外科学 | 597篇 |
综合类 | 61篇 |
预防医学 | 78篇 |
眼科学 | 86篇 |
药学 | 188篇 |
中国医学 | 3篇 |
肿瘤学 | 124篇 |
出版年
2024年 | 1篇 |
2023年 | 22篇 |
2022年 | 45篇 |
2021年 | 70篇 |
2020年 | 33篇 |
2019年 | 45篇 |
2018年 | 62篇 |
2017年 | 58篇 |
2016年 | 75篇 |
2015年 | 96篇 |
2014年 | 112篇 |
2013年 | 168篇 |
2012年 | 215篇 |
2011年 | 234篇 |
2010年 | 130篇 |
2009年 | 100篇 |
2008年 | 236篇 |
2007年 | 249篇 |
2006年 | 226篇 |
2005年 | 219篇 |
2004年 | 203篇 |
2003年 | 166篇 |
2002年 | 107篇 |
2001年 | 77篇 |
2000年 | 44篇 |
1999年 | 33篇 |
1998年 | 20篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 7篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 8篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1963年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有3115条查询结果,搜索用时 62 毫秒
31.
Sibel Berker Karauzum Duygu Yasar Ercument Dirice Nilufer Imir Guven Luleci 《Growth factors (Chur, Switzerland)》2013,31(2):94-100
Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder with pathological manifestations usually including splenomegaly and panctopenia. Interferons (IFNs), specifically of the α subtypes have shown a significant anti-tumor effect in HCL patients, with improvement of hematological parameters within the first few months of treatment. However, the therapeutic effect of IFN-α is still rather limited. The mechanisms responsible for the beneficial action of IFN-α in HCL patients are unclear. A continuous line of cells (Eskol) from a patient diagnosed with HCL was established and shown to have several properties of HCL. Even though, Eskol cells are very resistant to anti-proliferative activity of IFN-α, Daudi cells, another human B-cell-derived cell line, are very sensitive to anti-proliferative activity of IFN-α and are commonly used as a model cell to test anti-proliferative effect of IFN-α. To understand the molecular reason(s) behind the observed obvious differences to IFN sensitivity of above cells, we have analyzed the expression levels of BCL2, caspase-1, Laminin and PARP in these cells. We found that Daudi cells do not express BCL2 at all, and probably because of that, these cells have constantly cleaved, and probably activated form of caspase-1. However, when we overexpresed BCL2 in these cells, they lost processed form of caspase-1 and became resistant to anti-proliferative activity of IFN-α. These results let us to suggest that IFN-α sensitivity of B-cell lymphomas, once again, depends on the presence or absence of BCL2. 相似文献
32.
Ertugrul Uzar Harun Alp Mehmet Ugur Cevik Ugur F?rat Osman Evliyaoglu Adnan Tufek Yasar Altun 《Neurological sciences》2012,33(3):567-574
The aim of this study was to investigate the possible effects of ellagic acid in brain and sciatic nerve tissues of diabetic rats. Also, the impact of ellagic acid on catalase and paraoxonase (PON-1) activities, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and nitric oxide (NO) were examined. The rats were randomly divided into four groups, with eight rats each: Normal controls (not diabetic), only ellagic acid treated (ellagic acid controls, not diabetic), Diabetic controls (streptozotocin, diabetic), ellagic acid-treated diabetic (streptozotocin?+?ellagic acid). After a 4?week experiment, rats were sacrificed, and biomarkers for oxidative stress in the brain and sciatic nerve tissues of the rats were measured. There was significant depletion in the PON-1, catalase, and TAS levels in the brain and sciatic nerve tissues compared to the control groups (for both parameters, p?<?0.05). The values of catalase, PON-1 and TAS reversed back to normal levels in ellagic acid-treated diabetic rats compared to untreated diabetic rats (for both parameters, p?<?0.05). The levels of MDA, TOS, NO and, OSI in the brain and sciatic nerve tissues were higher in untreated diabetic rats compared to control group (for both parameters p?<?0.05). However, MDA, TOS, OSI, and NO levels were found to be significantly reduced in the ellagic acid-treated diabetic group compared to the untreated diabetic group in these tissues (for both parameters, p?<?0.05). In conclusion, the results of the present study suggested that ellagic acid exhibits neuroprotective effects against oxidative damage in diabetic rats. 相似文献
33.
34.
Evren Fidan Halil Kavgaci Asim Orem Mustafa Yilmaz Bulent Yildiz Sami Fidan Buket Akcan Feyyaz Ozdemir Fazil Aydin 《Tumour biology》2012,33(5):1519-1525
The relation between cancer and coagulation is the subject of investigation since a relation between tumor and thrombosis has been determined. Antithrombin III is an important thrombin inhibitor, and increased thrombin?Cantithrombin (TAT) complex levels activate coagulation. Activated thrombin activatable fibrinolysis inhibitor (TAFI) inhibits the conversion of plasminogen to plasmin. In addition, it directly inactivates plasmin. Defective fibrinolysis increases the risk of thrombosis. In this study, we evaluated homeostatic parameters, TAFI, and TAT levels in patients with gastric cancer applying to the medical oncology outpatient clinic. Fifty-two patients and 35 healthy controls were included. ELISA was used to measure TAFI and TAT complex levels. These were statistically higher in the patient group (p?<?0.05 and p?=?0.001, respectively). D-dimer levels were higher in stage IV (p?=?0.05). Correlations between lymph nodes and TAFI and TAT levels were examined. Weak but positive correlation between lymph nodes and TAFI was detected (R?=?0.452, p?=?0.027). TAFI and TAT levels were evaluated using relative operating characteristic analysis to differentiate the disease. TAT was more specific than TAFI according to this analysis (TAFI area under curve (AUC), 0.676; TAT AUC, 0.874). Thrombotic events and bleeding disorders need to be borne in mind in gastric cancer. This situation is due to the impairment of the balance between coagulation and fibrinolysis. Further studies are now needed to evaluate the effects of TAFI and TAT on survey and prognosis as well as the potential of these parameters as tumor markers for gastric cancer. 相似文献
35.
Sule Caglayan Sozmen M.D. Sakine Isik M.D. Zeynep Arikan Ayyildiz M.D. Kaan Yildiz M.D. Yasemin Cakır M.D. Erdener Ozer M.D. Suna Asilsoy Nevin Uzuner Ozkan Karaman Ozden Anal 《Pediatric dermatology》2015,32(2):e54-e57
Omenn syndrome is a combined immunodeficiency characterized by a generalized erythematous skin rash, enlarged lymph nodes, hepatosplenomegaly, severe susceptibility to infections, eosinophilia, and hyperimmunoglobulinemia E. A 3‐month‐old girl was admitted to our hospital with a history of recurrent sepsis. Physical examination revealed severe erythroderma, hepatosplenomegaly, lymphadenopathy, and failure to thrive. Laboratory findings revealed leukocytosis, lymphocytosis with high CD3 T‐cells, a high CD4:CD8 ratio, absence of CD19 B‐cells, high eosinophil count, and low immunoglobulin levels. A heterozygote RAG1 gene mutation was found. She had itchy, scaling, ichthyosiform erythroderma and protracted diarrhea. Cyclosporin treatment up to 10 mg/kg effectively resolved erythroderma and lowered total eosinophil counts, and she gained weight during treatment. Since extensive erythroderma with generalized itching causes patient discomfort in Omenn syndrome, cyclosporin treatment can be considered while waiting for treatment with hematopoietic stem cell transplantation. 相似文献
36.
37.
38.
39.
The purpose of this study was to determine the effect of the Grief Support Program on the bereavement of parents whose babies had died. The sample consisted of 77 couples. The data was collected by the Texas Revised Inventory of Grief and the Coping Strategies Inventory. The intervention group was offered before, immediately after, and a month after death of their baby in accordance with the Grief Support Program guideline. The Grief Support Program did not affect grief intensity in the short term but had a positive effect 1 year later. 相似文献
40.