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Margueritta Al Zallouha Yann Landkocz Clémence Méausoone Fréderic Ledoux Fabien Visade Fabrice Cazier Perrine J. Martin Mireille Borgie Jean-Jacques Vitagliano Gauthier Trémolet Jean-Charles Cailliez Pierre Gosset Dominique Courcot Sylvain Billet 《Journal of applied toxicology : JAT》2020,40(5):619-630
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Metabolic voxel‐based analysis of the complete human brain using fast 3D‐MRSI: Proof of concept in multiple sclerosis 下载免费PDF全文
Maxime Donadieu MS Yann Le Fur PhD Angèle Lecocq PhD Andrew A. Maudsley PhD Soraya Gherib MS Elisabeth Soulier BS Sylviane Confort‐Gouny PhD Fanelly Pariollaud PhD Marie‐Pierre Ranjeva PhD Jean Pelletier MD PhD Maxime Guye MD PhD Wafaa Zaaraoui PhD Bertrand Audoin MD PhD Jean‐Philippe Ranjeva PhD 《Journal of magnetic resonance imaging : JMRI》2016,44(2):411-419
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Brousseau M Bertrand G Lavoine E Kettani S Rabarin F Saint-Cast Y Massin P Rousselet MC 《Annales de pathologie》2007,27(1):38-42
Acral myxoinflammatory fibroblastic sarcoma is a rare low-grade malignant soft tissue tumor, usually observed in the extremities of middle-aged adults. We report two cases which occurred in the thumb and knee of middle-aged women. Both tumors showed a multinodular architecture, with cellular areas, occasional foci of hyalinized fibrosis, and hypocellular areas with a myxoid background. Various neoplastic cells were identified including spindled or rounded epithelioid cells and occasional bizarre giant cells, morphologically mimicking Reed-Sternberg cells or ganglion cells. Tumor cells were strongly immunoreactive for vimentin, and variably positive for CD68 and CD34. Both tumors were completely resected and patients were free of disease without any further treatment after a mean follow-up of 14 months. 相似文献
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Yann Gueguen Caroline Rouas Audrey Monin Line Manens Johanna Stefani Olivia Delissen Stéphane Grison Isabelle Dublineau 《Archives of toxicology》2014,88(2):227-239
Enzymes that metabolize xenobiotics (XME) are well recognized in experimental models as representative indicators of organ detoxification functions and of exposure to toxicants. As several in vivo studies have shown, uranium can alter XME in the rat liver or kidneys after either acute or chronic exposure. To determine how length or level of exposure affects these changes in XME, we continued our investigation of chronic rat exposure to depleted uranium (DU, uranyl nitrate). The first study examined the effect of duration (1–18 months) of chronic exposure to DU, the second evaluated dose dependence, from a level close to that found in the environment near mining sites (0.2 mg/L) to a supra-environmental dose (120 mg/L, 10 times the highest level naturally found in the environment), and the third was an in vitro assessment of whether DU exposure directly affects XME and, in particular, CYP3A. The experimental in vivo models used here demonstrated that CYP3A is the enzyme modified to the greatest extent: high gene expression changed after 6 and 9 months. The most substantial effects were observed in the liver of rats after 9 months of exposure to 120 mg/L of DU: CYP3A gene and protein expression and enzyme activity all decreased by more than 40 %. Nonetheless, no direct effect of DU by itself was observed after in vitro exposure of rat microsomal preparations, HepG2 cells, or human primary hepatocytes. Overall, these results probably indicate the occurrence of regulatory or adaptive mechanisms that could explain the indirect effect observed in vivo after chronic exposure. 相似文献