Effect of the Amount of Hours Spent Studying on the Prevalence of Overactive Bladder in College Women

Objectives: We conducted a questionnaire survey to access whether the amount of hours spent studying has an effect on the prevalence of OAB in college women. Methods: A total of 126 (63%; mean: 23.2 years) of 200 women participants completed the questionnaire. They were divided into two groups: group A (weekly studying hour >40 h) consisted of medical female students and group B (weekly studying hour <25 h) consisted of French literature woman students. The factors related to OAB were analyzed by the chi‐squared test. Results: Of 126 respondents, the prevalence of OAB was prevalent in 38 (30.2%) women. There was significant difference in prevalence between the two groups: 7.0% for group A and 42.2% for group B. In group B, OAB prevalence was 66.7% for ≤2 h, 41.2% for 2–≤4 h, 46.5% for 4–≤6 h, and >6 h was 23.5%. This survey showed that there is no relationship between the amount of hours spent studying and OAB. Conclusion: Although the amount of hours spent studying had no association with OAB in college women, OAB prevalence showed a decreasing pattern as the quantity of studying hour increases. Consequently, it is thought that the attitude toward study has more association with OAB than the quantity of studying hours.     

Secretion of Gastric Inhibitory Polypeptide in Patients with Bile Duct Obstruction

Background: The usefulness of the rapid urease test (RUT) in diagnosing Helicobacter pylori infection after peptic ulcer surgery is unknown. Methods: Patients who had undergone peptic ulcer surgery were offered endoscopic examination if they presented with dyspepsia or gastrointestinal bleeding. Biopsy specimens were taken for RUT and histology from the corpus and the stoma in patients who had undergone partial gastrectomy or from the corpus and the antrum in patients who had undergone vagotomy. Histologic examination using haematoxylin and eosin stain and Warthin-Starry stain were used as the gold standard. Results: Ninety patients were studied (69 had partial gastrectomy and 21 had vagotomy). Forty-three patients (32 in the partial gastrectomy group and 11 in the vagotomy group) were positive for H. pylori by histology. The respective sensitivity of RUT was 59% (stoma) and 75% (corpus) in the partial gastrectomy group (P = 0.36) and 55% (antrum) and 73% (corpus) in the vagotomy group (P = 0.51). Conclusions: RUT is not sensitive for detecting H. pylori after acid reduction surgery.     

Successful Treatment of Lichen Spinulosus with Topical Tacalcitol Cream

Abstract: Lichen spinulosus (LS) is a rare idiopathic cutaneous eruption characterized by follicular keratotic spiny papules that are grouped in large patches. Here, we report two cases of LS in the submental area, an uncommon site, which were treated effectively and safely with topical tacalcitol cream.     

Etoricoxib improves pain,function and quality of life: results of a real‐world effectiveness trial

Objective: To evaluate the effectiveness and tolerability of etoricoxib in patients with osteoarthritis (OA) with suboptimal response to existing pain regimens. Methods: A multicenter, prospective, open‐label, single‐arm study. OA patients (n = 500) taking nonsteroidal anti‐inflammatory drugs (NSAIDs) or other analgesics who had inadequate response as determined by their physicians (≥ 40 mm on a 0–100 mm pain scale) were switched directly to etoricoxib 60 mg once daily for 4 weeks without prior medication washout. The primary endpoint was the percentage of patients with ≥ 30% improvement in Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) pain walking on a flat surface after 4 weeks of treatment. Other endpoints included WOMAC Pain, Stiffness, and Physical Function subscales, Brief Pain Inventory (BPI), investigator’s global assessment of response to therapy (IGART), the Treatment Satisfaction Questionnaire for Medication (TSQM) and Short Form 36 (SF36). Safety and tolerability were assessed by collecting adverse events. Results: After switching to etoricoxib, 52% (95% confidence interval: 47%, 57%) of patients reported a clinically meaningful reduction (≥ 30%) for WOMAC pain walking on a flat surface. Disability in daily activities and pain interference were significantly improved (P < 0.0001). IGART scores improved after the switch to etoricoxib (P < 0.05). Results from TSQM demonstrated that patient perceptions of effectiveness, convenience and overall satisfaction increased. Etoricoxib was generally well tolerated in most patients. The most commonly reported adverse event was edema (4.2%). Conclusions: In OA patients experiencing inadequate relief from a wide variety of analgesics, pain, function, quality of life, and treatment satisfaction significantly improved when switched to etoricoxib.     

结肠癌HT-29细胞中PIDD蛋白的表达及其对细胞耐药性的影响

目的:以结肠癌HT-29细胞株为载体,研究PIDD(p53-induced protein with a death domain)蛋白在结肠癌耐药中的作用机制.方法:构建并转染PIDD基因的小干扰RNA(small interfering RNA,siRNA)片段,用Western印迹法检测其干扰效果.通过MTT比色法检测细胞对化疗药物的敏感性,并用凝胶阻滞分析(electrophoretic mobility shift assay,EMSA)法检测核因子NF-κB活性的变化.结果:RNA干扰后给予细胞药物刺激,细胞核中PIDD表达下降,核因子NF-κB活性明显降低,细胞耐药性下降.结论:转染siRNA后,HT-29细胞对5-氟尿嘧啶(5-fluorouracil, 5-FU)的敏感性增加,此作用可能与细胞核PIDD复合体减少、核因子NF-κB活性减低及细胞凋亡增多有关.