全文获取类型
收费全文 | 60997篇 |
免费 | 5795篇 |
国内免费 | 3413篇 |
专业分类
耳鼻咽喉 | 511篇 |
儿科学 | 874篇 |
妇产科学 | 1005篇 |
基础医学 | 7011篇 |
口腔科学 | 1079篇 |
临床医学 | 7131篇 |
内科学 | 9872篇 |
皮肤病学 | 733篇 |
神经病学 | 2913篇 |
特种医学 | 2524篇 |
外国民族医学 | 34篇 |
外科学 | 7335篇 |
综合类 | 9066篇 |
现状与发展 | 15篇 |
一般理论 | 16篇 |
预防医学 | 3964篇 |
眼科学 | 1485篇 |
药学 | 6517篇 |
52篇 | |
中国医学 | 3078篇 |
肿瘤学 | 4990篇 |
出版年
2024年 | 176篇 |
2023年 | 842篇 |
2022年 | 2079篇 |
2021年 | 2856篇 |
2020年 | 2065篇 |
2019年 | 1889篇 |
2018年 | 2031篇 |
2017年 | 1806篇 |
2016年 | 1796篇 |
2015年 | 2494篇 |
2014年 | 3156篇 |
2013年 | 3172篇 |
2012年 | 4450篇 |
2011年 | 4723篇 |
2010年 | 3067篇 |
2009年 | 2513篇 |
2008年 | 3362篇 |
2007年 | 3422篇 |
2006年 | 3174篇 |
2005年 | 2962篇 |
2004年 | 2391篇 |
2003年 | 2208篇 |
2002年 | 2002篇 |
2001年 | 1666篇 |
2000年 | 1596篇 |
1999年 | 1439篇 |
1998年 | 774篇 |
1997年 | 780篇 |
1996年 | 630篇 |
1995年 | 530篇 |
1994年 | 463篇 |
1993年 | 313篇 |
1992年 | 506篇 |
1991年 | 412篇 |
1990年 | 388篇 |
1989年 | 345篇 |
1988年 | 274篇 |
1987年 | 260篇 |
1986年 | 205篇 |
1985年 | 160篇 |
1984年 | 117篇 |
1983年 | 84篇 |
1982年 | 60篇 |
1981年 | 73篇 |
1980年 | 39篇 |
1979年 | 72篇 |
1978年 | 37篇 |
1974年 | 36篇 |
1973年 | 33篇 |
1972年 | 41篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
目的 探究注意缺陷多动障碍儿童初始沙盘游戏特征.方法 对29名注意缺陷多动障碍儿童和29名正常儿童进行沙盘游戏干预,对照分析两组儿童初始沙盘游戏主题及沙具使用情况.结果 注意缺陷多动障碍儿童沙盘游戏主题较正常儿童混乱无序,两组比较差异有统计学意义(χ2=22.58,P<0.00);两组儿童在沙具使用方面比较差异无统计学意义(均P>0.05).结论 注意缺陷多动障碍儿童沙盘游戏具有独特特征以及一定的临床诊断筛查价值. 相似文献
62.
HPLC法测定双红活血胶囊中黄芪甲苷的含量 总被引:2,自引:0,他引:2
目的 测定双红活血胶囊中黄芪甲苷的含量。方法 采用高效液相色谱 (HPLC)法测定。结果 平均回收率为 1 0 0 .6%,CV =1 .62 %。结论 该方法简便 ,准确 相似文献
63.
64.
65.
Vanaporn Wuthiekanun Varunee Desakorn Gumphol Wongsuvan Premjit Amornchai Allen C. Cheng Bina Maharjan Direk Limmathurotsakul Wirongrong Chierakul Nicholas J. White Nicholas P. J. Day Sharon J. Peacock 《Clinical and Vaccine Immunology : CVI》2005,12(4):555-556
An immunofluorescent (IF) method that detects Burkholderia pseudomallei in clinical specimens within 10 min was devised. The results of this rapid method and those of an existing IF method were prospectively compared with the culture results for 776 specimens from patients with suspected melioidosis. The sensitivities of both IF tests were 66%, and the specificities were 99.5 and 99.4%, respectively. 相似文献
66.
Hiroko Utsunomiya Wanninayake M. Tilakaratne Kazufumi Oshiro Satoshi Maruyama Makoto Suzuki Hiroko Ida-Yonemochi Jun Cheng Takashi Saku 《Journal of oral pathology & medicine》2005,34(8):498-507
BACKGROUND: Oral submucous fibrosis (OSF) is a chewing habit-related pre-cancerous condition of the oral mucosa affecting predominantly south Asians. It is histopathologically characterized by epithelial atrophy and fibrosis of the subepithelial connective tissue. Fibrosis extends all the way into the muscle layer, leading to difficulty in mouth opening. However, the dynamics of extracellular matrix (ECM) remodeling with OSF progression is largely unknown. METHODS: Forty biopsy specimens of OSF and 10 of normal buccal mucosa were examined for expression/deposition modes of eight ECM molecules by histochemistry, immunohistochemistry, and in situ hybridization. RESULTS: In the early stage of OSF, tenascin, perlecan, fibronectin, collagen type III were characteristically enhanced in the lamina propria and the submucosal layer. In the intermediate stage, the ECM molecules mentioned above and elastin were extensively and irregularly deposited around muscle fibers. In the advanced stage, such ECM depositions decreased and were entirely replaced with collagen type I only. Their gene expression levels varied with progression of fibrosis, but the mRNA signals were confirmed in fibroblasts in the submucosal fibrotic areas. CONCLUSIONS: The results indicate that the ECM remodeling steps in OSF are similar to each phase of usual granulation tissue formation. Restricted mouth opening may be a result of loss of variety of ECM molecules including elastin into the homogeneity of collagen type I replacing muscle fibers. 相似文献
67.
Systemic anticancer therapy for hepatocellular carcinoma (HCC) is limited by intrinsic drug resistance and accompanying liver
dysfunction. However, recent advances in molecular targeted therapy (MTT) have shed light on the treatment of advanced HCC.
A recent randomized, placebo-controlled trial demonstrated that sorafenib, a multi-target tyrosine kinase inhibitor, prolonged
overall survival and time-to-progression in patients with advanced HCC. This breakthrough highlights the potential of MTT
targeting hepatocarcinogenic pathways, such as the Raf/MAPK/ERK pathway, angiogenic pathways and the EGFR signaling pathway.
This review discusses the current status and the potential of developing novel MTTs for advanced HCC. 相似文献
68.
69.
Although many monoclonal antibodies have been made in human colon cancer, none of them are from the Chinese species. Recently, a colon cancer cell line CC-M2 established from a Chinese patient has been completely characterized and used as immunogen to produce monoclonal antibodies. Monoclonal antibodies were produced by standard hybridoma technique. The fusion rate was 95.8%. An isotype IgG1 of high proliferation named as Sam-2 was used in this study. The titers were measured around 10(4). Further studies on MoAb Sam-2 through indirect immunofluorescent and immunoperoxidase tests revealed its good specificity and sensitivity in colorectal cancer tissue. In CEA study, the result indicated that Sam-2 may react on a non-CEA related antigen. For further clinical application, the antigen was identified as a glycoprotein by chemical resistant test. In preliminary studies using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting techniques, Sam-2 could recognize two closed antigens or a dimer antigen with molecular weight 25.2 and 27 Kd respectively. 相似文献
70.
枢复宁在肺癌患者体内的药物动力学和生物利用度 总被引:3,自引:1,他引:2
9名接受顺铂化疗的原发性肺癌患者单次口服和静脉注射枢复宁8mg后,用反相高效液相色谱法测定血浆药物浓度。经用PKBP-N1程序在计算机上拟合计算表明,枢复宁在人体内表现为二房室模型。口服后主要药动学参数:T1/2Ka=0.41±0.30h,T1/2α=0.9±0.43h,T1/2β=3.3±1.2h,Cmax=28.6±9.5ng/ml,Tmax=1.7±0.9h,AUC=158±73ng·h/ml,绝对生物利用度为55%。 相似文献