Effect of arotinolol on right ventricular function in patients with dilated cardiomyopathy

Objective Dilated cardiomyopathy (DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study, we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction (RVEF) and right ventricular diameter (RVD) were measured by two-dimensional echocardiography (2-DE) in 33 DCM patients; RVEF measured by first-pass radionuclide angiography (FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter (baseline, 23.0 ± 8.3 mm vs after one-year treatment, 20.7 ± 5.4 mm; P=0.004 ) and an associated increase in ejection fraction (baseline, 36.9 ± 10.3% vs after one-year treatment, 45.8 ± 9.6%; P ＜ 0.001 ); there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933 (P＜0.001). Conclusion Arotinolol therapy could not only improve left ventricular function, but also improve right ventricular function in DCM patients.     

云南药用植物根结线虫病调查

1994－1997年对云南省20余县市,52种药用植物根结线虫病情况进行了调查,共采集185份标本,其中76份标本鉴定有4种根结线虫：南方根结线虫、爪哇根结线虫、花生根结线虫和北方根结线虫,并引起21种药用植物的根结线虫病。文章概述了21种药用植物根结线虫病的危害程度及分布。     

钢板前置内固定治疗锁骨骨折的疗效

目的评价钢板前置内固定治疗锁骨中段骨折的临床疗效。方法 2006年9月—2010年8月,采用切开复位钢板前置内固定术治疗53例锁骨中段移位骨折患者,其中Robinson 2A2型27例、2B1型23例、2B2型3例。分别于术后第3、6周和术后第3、6、12、18个月拍摄锁骨X线片观察骨折愈合情况,以Constant标准评价患侧肩关节功能。结果所有患者术后均获随访,平均随访时间为(13.4±2.2)个月。锁骨X线片显示骨折均骨性愈合,平均愈合时间为(3.6±0.7)个月。52例患者行肩关节功能的Constant评分,疗效评价为优34例、良16例、可2例,总体优良率为96.2%(50/52)。结论钢板前置内固定是治疗锁骨中段移位骨折的一种有效方法。     

AQP3、7、9在人下颌下腺的免疫组化定位

采用免疫组化ABC法检测源自10例颈淋巴清扫患者的正常下颌下腺组织AQP3、7、9蛋白的表达。AQP3在浆液性腺泡和黏液性腺泡细胞均有表达,分布于腺泡细胞的基底膜和侧膜,在浆液性腺泡细胞中的表达明显高于黏液性腺泡细胞,导管系统未见AQP3表达;AQP7在极少数肌上皮细胞有表达;AQP9在部分浆液性腺泡腔、混合性腺泡腔以及部分闰管管腔和浆液性半月体上有表达。     

The role of urine IgG in the progression of IgA nephropathy with a high proportion of global glomerulosclerosis

International Urology and Nephrology - IgA nephropathy (IgAN), the most common glomerulonephritis in the world, is an important cause of end-stage renal disease (ESRD). It is necessary to explore...     

脱氧胆酸诱导大肠癌发生的研究

胆汁酸中的脱氧胆酸可以促进肿瘤的形成,脱氧胆酸诱发的细胞凋亡在大肠癌的发生中起着重要作用。提高粪便中胆汁酸含量可增加患大肠癌的风险,表明脱氧胆酸可以促进大肠癌的发生、发展。脱氧胆酸作为一种促癌因子在大肠癌的发生中起很大作用,同时通过多种机制诱发大肠癌的发生。     

Successful treatment of hemophagocytic syndrome in a patient with T cell lymphoma,EBV infection,and bone marrow necrosis: A case report

Rationale:Hemophagocytic syndrome (HPS) is associated with a high mortality rate, and Epstein–Barr virus infection and hematological malignancies, especially T/natural killer cell lymphomas, are the most common causes; however, due to the complexity of clinical manifestations, the diagnosis is usually delayed. There are few reports of lymphoma-associated HPS (LAPS) in combination with bone marrow necrosis, and there is still no standard treatment for LAPS.Patient concerns:A 64-year-old man developed a fever, mild jaundice, fatigue, and bone pain. Positron emission tomography and bone marrow biopsy with immunohistochemistry were performed.Diagnosis:Imaging analysis and bone marrow examinations were compatible with HPS, T-cell lymphoma, and bone marrow necrosis.Interventions:The patient received combination therapy of rituximab and Cyclophosphamide, epirubicin, vincristine, glucocorticoid, etoposide.Outcomes:The patient achieved complete remission and a disease-free survival of 52 months.Lessons:HPS and its potential diseases should be diagnosed and treated as soon as possible. Clinicians should be aware of the presence of lymphoma in patients with HPS. Rituximab plays an important role in the prognosis of HPS, particularly Epstein–Barr virus positivity. Cyclophosphamide, epirubicin, vincristine, glucocorticoid remains an effective regimen for the treatment of T-cell LAPS. This study provides a better understanding of the diagnosis and treatment of LAPS.     

Muir-Torre综合征的研究进展

Muir-Torre综合征(MTS)是一种罕见的遗传性疾病,本病的发生与DNA错配修复的种系突变相关。临床表现为皮肤肿瘤(以皮脂腺腺瘤多见)和内脏恶性肿瘤(以胃肠道恶性肿瘤多见)。免疫组化和基因检测是本病的常用诊断方法。确诊后需要进行手术治疗及化学治疗。     

高要产广藿香挥发油成分分析

应用气相色谱-质谱联用技术对高要产广藿香茎和叶中挥发油成分进行了分析,从茎油中分离出107个色谱峰,鉴定了52个化合物,占总量的78.83％;从叶油中分离出50个色谱峰,鉴定了36个化合物,占总量的96.95％。茎和叶油中主要含广藿香酮(分别为30.99％和21.31％)、广藿香醇(10.26％和37.53％)反式-丁香烯(4.92％和6.75％)、α-愈创木稀(2.27％和6.18％)、反式,反式-法呢醛(2.04％和1.40％)、α-广藿香烯(1.13％和2.71％)、刺蕊草烯(1.56％和1.99％)等。茎与叶挥发油中亦存在一些差异:茎中有27个成分是叶中没有或含量极微而未能检出,叶中亦有11个成分是茎中不具有的。     

氨甲环酸的使用方式对全髋置换术显隐性失血影响的研究

目的：通过分组对照实验,探讨氨甲环酸的不同使用方式对全髋关节置换术（THA）显隐性失血的影响。方法病例选自该院骨科2010年3月至2013年8月共60例患者。诊断：股骨颈骨折47例,股骨头坏死13例;年龄45～82岁,平均62岁,均接受单侧T H A。所有病例分为A组、B组和C组共3组,各20例,经过筛选,每组男性6例,女性14例,均为初次全髋置换。A组术前0．5 h、术后3 h分别予100 mL生理盐水静滴;B组术前0．5 h将氨甲环酸按10 mg／kg稀释于100 mL生理盐水中静滴,术后3 h予100 mL生理盐水静滴;C组术前0．5 h、术后3 h分别将氨甲环酸按10 mg／kg稀释于100 mL生理盐水中静滴。计算各组患者的显性及隐性失血量,并进行统计学分析,探讨实验组中氨甲环酸2种使用方式的有效性及安全性。结果显性红细胞丢失量：A组（196．20±44．45）m L ,B组（114．84±35．21）m L ,C组（104．47±30．01）m L ;隐性红细胞丢失量：A组（614．50±98．41）m L ,B组（425．74±70．01）m L ,C组（337．12±52．23）m L。结论氨甲环酸的使用能明显减少T H A的显隐性失血量,术前0．5h合并术后3h使用较术前0．5h使用对减少隐性失血量效果更佳,进一步减少输血量,且不会明显增加下肢深静脉血栓形成的发生率。