全文获取类型
收费全文 | 259931篇 |
免费 | 59106篇 |
国内免费 | 12377篇 |
专业分类
耳鼻咽喉 | 3047篇 |
儿科学 | 6428篇 |
妇产科学 | 3397篇 |
基础医学 | 34731篇 |
口腔科学 | 8241篇 |
临床医学 | 37058篇 |
内科学 | 49434篇 |
皮肤病学 | 9504篇 |
神经病学 | 21314篇 |
特种医学 | 8420篇 |
外国民族医学 | 85篇 |
外科学 | 31117篇 |
综合类 | 34651篇 |
现状与发展 | 43篇 |
一般理论 | 27篇 |
预防医学 | 18438篇 |
眼科学 | 6087篇 |
药学 | 25699篇 |
186篇 | |
中国医学 | 12152篇 |
肿瘤学 | 21355篇 |
出版年
2024年 | 559篇 |
2023年 | 2434篇 |
2022年 | 6364篇 |
2021年 | 9216篇 |
2020年 | 10860篇 |
2019年 | 15700篇 |
2018年 | 15182篇 |
2017年 | 16349篇 |
2016年 | 16465篇 |
2015年 | 19133篇 |
2014年 | 21118篇 |
2013年 | 21299篇 |
2012年 | 18067篇 |
2011年 | 19282篇 |
2010年 | 19302篇 |
2009年 | 14168篇 |
2008年 | 13059篇 |
2007年 | 11972篇 |
2006年 | 11749篇 |
2005年 | 10852篇 |
2004年 | 7963篇 |
2003年 | 7565篇 |
2002年 | 6563篇 |
2001年 | 5725篇 |
2000年 | 5308篇 |
1999年 | 4622篇 |
1998年 | 2807篇 |
1997年 | 2780篇 |
1996年 | 1982篇 |
1995年 | 1790篇 |
1994年 | 1614篇 |
1993年 | 1017篇 |
1992年 | 1384篇 |
1991年 | 1218篇 |
1990年 | 1036篇 |
1989年 | 905篇 |
1988年 | 773篇 |
1987年 | 731篇 |
1986年 | 548篇 |
1985年 | 492篇 |
1984年 | 255篇 |
1983年 | 185篇 |
1982年 | 128篇 |
1981年 | 123篇 |
1980年 | 79篇 |
1979年 | 124篇 |
1978年 | 62篇 |
1976年 | 53篇 |
1975年 | 55篇 |
1974年 | 70篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Metabolic Brain Disease - Bupleurum chinense DC. (Chaihu) is a traditional Chinese medicine (TCM) used in the treatment of anxiety. But the anxiolytic mechanisms of bupleurum are still unclear.... 相似文献
102.
Ju Zou Daichao Wu Tao Li Xianwen Wang Yan Liu Sijie Tan 《Pathology, research and practice》2019,215(2):229-234
Programmed death ligand 1(PD-L1) mediated immune escape play important roles in the development of cancer. The gene polymorphism of PD-L1, in particular rs4143815 C?>?G, has been associated with the cancer risks, but with conflicting results. Therefore, this meta-analysis was aimed to assess the association between rs4143815 C?>?G and cancer susceptibility. A systematic literature search was performed to select the studies and the pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. Eleven eligible studies containing 3711 cases and 3704 controls were enrolled in the meta-analysis. The results suggested that there is a strong association between rs4143815 C?>?G and the cancer risks (G vs. C: OR?=?1.386, 95% CI: 1.132–1.696, p?=?0.002; GG vs. CG?+?CC: OR?=?1.843 95% CI: 1.300–2.613, p?=?0.002; GG?+?CG vs. CC: OR?=?1.280, 95% CI: 1.040–1.576, p?=?0.020). Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C?>?G might increase the susceptibility to gastric cancer (G vs. C: OR?=?1.842, 95% CI: 1.403–2.418, p?<?0.001) and bladder cancer (G vs. C: OR?=?2.015, 95% CI: 1.556–2.608, p?<?0.001), and genotype GG carriers of PD-L1 rs4143815 C?>?G might have higher risks of HCC (GG vs. CG?+?CC: OR?=?2.226 95% CI: 1.562–3.172, p?<?0.001). PD-L1 rs4143815 C?>?G might confer an increased cancer risk, indicating this SNP may contribute to the pathogenesis of cancer and might be used as a potential biomarker to predict the susceptibility to cancer. 相似文献
103.
104.
105.
106.
Luis Veloza Cristina Teixido Natalia Castrejon Fina Climent Ana Carri Marta Marginet Davide Soldini Blanca Gonzlez‐Farr Inmaculada Ribera‐Cortada Armando Lopez‐Guillermo Eva Gonzlez‐Barca Adriana Sierra Mileyka Herrera Cndida Gmez Adriana Garcia Olga Balagu Elias Campo Antonio Martinez 《Histopathology》2019,75(6):799-812
107.
Leyi Wang Saraswathi Lanka Debbie Cassout Nohra E. Mateus‐Pinilla Ganwu Li William C. Wilson Dongwan Yoo Paul Shelton Richard L. Fredrickson 《Transboundary and Emerging Diseases》2019,66(5):1809-1820
First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double‐stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year. 相似文献
108.
109.
110.
Mei-Yi Wu Yu-Wei Chen Lie-Yee Hung Chii-Hong Lee Hsin-An Chen Yung-Ho Hsu Mai-Szu Wu 《Transplantation proceedings》2019,51(5):1472-1474
IntroductionThe immunosuppressant agents in kidney transplantation (KT) may lead to various complications such as opportunistic infections and malignancies. BK virus associated nephropathy is a significant complication following KT, and it can result in graft failure. BK virus causes tubulointerstitial nephritis, ureter stenosis, and even graft failure in KT recipients with impaired immune system. We described a 63-year-old woman, who was a hepatitis C carrier and on dialysis for 22 years before KT, who received cadaveric-donor KT 2 years previously. She reported decreasing urine output and general weakness. The serum creatinine level was slightly increased from 2.94 to 4.38 mg/dL.MethodsImmunosuppressant medications including prednisolone, everolimus, cyclosporin, and mycophenolate sodium were continued as maintenance therapy post KT. Kidney biopsy was performed due to deterioration of graft function.ResultsThe kidney biopsy showed consistent results with early-stage polyomavirus nephropathy, characterized by focal viral cytopathic changes with positive immunohistochemical signals and mesangial proliferative glomerulonephritis, immune-complex-mediated (Fig 1 and Fig 2). Negative C4d staining at peritubular capillary was reported. The dosage of mycophenolate sodium was tapered from 720 to 360 mg daily and that of everolimus increased from 0.5 to 1.0 mg daily due to BK viral infection with BK nephropathy. The serum creatinine level was 2.75 mg/dL after treatment.ConclusionEarly detection of BK nephropathy and decreasing immunosuppressant agents are the mainstay of treatment. Substituting leflunomide for mycophenolate sodium and increasing dosage of everolimus has been proposed to solve BK nephropathy. We presented that the use of leflunomide in such situation is in a timely manner. 相似文献