Comparison between laser and electrical ablation of ventricle in dogs: Hemodynamic,pathologic and electrocardiographic observations

Summary To characterize and compare the pathologic, hemodynamic and electrocardiographic changes of both transeatheter laser and electrical energy on ventricle, 33 subendocardial myocardium lesions were induced at energy 60, 120 and 240 Joules by either transcatheter laser irradiation or electrical shock in 7 anesthetized dogs. The following results were observed: 1) Both laser and electrical ablation on myocardium created nonhomogeneous myocardium injury, but laser ablation caused mainly focal tissue vaporization and necrosis, while electrical shock induced widespread tissue degenerations; 2) Both laser and electrical induced-lesion dimensions increased parallel to the total dosage of energy; 3) Laser ablation caused mainly (90%) single ventricular premature beats and 86 % of them occurred within the first minute after energy discharged, while ventricular tachycardias were found in any electrical energy groups; ventricular fibrillations occurring during laser and electrical ablation were 5 % and 13 % respectively (P< 0.01): 4) A decrease in aortic blood pressure and an increase in central verous pressure induced by laser ablation were significantly less than that produced by the same amount of electrical energy (P<0.0l). Our preliminary results have shown that transeatheter laser ablation has great potential for becoming a practical method in the management of refractory tachycardias.     

氨基酸、有机酸、碱基核苷类化合物的双向色谱多相同步分析

30余种氨基酸、40余种非挥发性有机酸和20余种碱基核苷类化合物在一块薄层板上完成多相同步色谱分析；用紫外灯-吖啶试剂-镉茚三酮试剂实行组合显色定位分析。改善了尿液中非挥发性有机酸的溶剂萃取法，尿中三类化合物提取物的同步多相色谱分离效果良好。     

医学司法鉴定中精神病患者反复上访原因分析

目的 了解司法鉴定中精神病患者反复上访原因。方法 对诊断为无精神病者与诊断为精神病偏执型人格障碍、偏执性精神病、精神分裂症者的上访诱因、动机、目的、内容、时间、形式、有否过激行为等进行比较。结果 上访诱因、动机、目的等方面以生活、工作、经济问题为主；上访时间以患病5—20a者居多。共33例(71．73％)：上访者中有过激行为者21例(45．65％)。结论 精神病患者上访者中以偏执型人格障碍、偏执性精神病、精神分裂症居多。其特点与正常人有所区别。这就要求政府部门在接待上访者及处理上访问题时。应加以严格区分并正确、合理解决上访要求。以免产生不良的社会问题。     

克罗米芬兴奋试验预测卵巢储备功能的价值

目的探讨克罗米芬兴奋试验（CCT）在不孕妇女中预测卵巢储备功能的作用。方法对2001年1月至2005年2月就诊于广东省妇幼保健院的666例不孕症患者作为研究对象，分为A组（≥35岁）461例为高龄组，B组（〈35岁）205例为低龄组，另取156例年龄〈35岁、非女方不孕原因者作为对照组，对三组受试者进行CCT。结果CCT异常发生率A组、B组及对照组分别为27．76％、34．14％、2．56％，A组及B组与对照组比较差异均有非常显著性意义（P〈0．01）。基础卵泡刺激素（FSH）〈10IU／L、雌二醇（E2）〈180pmot／L的不孕患者CCT异常发生率分剐为17．46％、24．19％，均明显低于FSH≥10IU／L、E2≥180pmol／L患者的64．19％及39．4％（P〈0．01）。结论CCT预测卵巢储备功能较基础FSH更敏感，CCT可作为常规了解卵巢储备功能的一项检测方法。     

甲壳素制备工艺改进——天然甲壳素的提取

甲壳素制备工艺改进为统一常温进行,操作简便,产品相对收率提高5～10％,同时降低了能耗、机械要求强度、劳动保护条件和生产成本,并经热分析说明产品维持了甲壳素的天然特性,即分子中每结构单元含有1/2分子缔合水,是天然的甲壳素产品并有益于其脱乙酰化物──壳聚糖质量的提高。     

辐照氟银猪皮的实验研究

报道辐照氟银猪皮的制备、实验检测（弹性、创面粘附力和透水性测定，含银量测定）组织学检查细菌检测及抑菌试验研究，结果表明：辐照氟银猪皮除延伸度低于未辐照猪皮外，其撕裂强度、创面粘合力和透水性均与未辐照猪皮相似。组织学检查示：辐照氟银猪皮组织结构完整，表皮细胞部分空泡形成。组织细菌检测证明其无菌生长，达到无菌要求。抑菌试验证明对金黄色葡萄球菌、绿脓杆菌、大肠杆菌、变形杆菌、克雷伯氏菌均有极强的抑菌作用     

Optimal metabolite curve fitting for kinetic modeling of 11C-WAY-100635.

Many quantitative imaging protocols that make use of a metabolite-corrected arterial input function require the use of a mathematic model to describe the rate of metabolism of the radioligand. Commonly, parametric models are fit to metabolism data and then the fitted model is used to correct the plasma input function. (11)C-WAY 100635 is a rapidly metabolized radioligand used extensively in mapping the 5-hydroxytryptamine receptor 1A system. METHODS: To evaluate the adequacy of fit of 4 metabolite models, we examined data from 92 subjects who received an injection of (11)C-WAY 100635, were imaged with PET, and underwent measurement of total plasma concentration and metabolites. The performance of these models was assessed according to residual plots, as well as fit and information criteria. RESULTS: The study showed that the choice of model has a substantial effect on the resulting estimates of outcome measures. CONCLUSION: Among the models considered, the Hill model provides the best fit across all criteria.     

458例尿路结石成分分析

目的 探讨西安地区尿路结石的成分状况，为临床防治提供帮助。方法对458例尿路结石标本进行化学成分测定，并结合临床资料进行比较。结果尿路结石男性发病多于女性，男、女比为2．1：1，20一50岁为高发年龄，上尿路结石明显多于下尿路结石，上、下尿路结石之比为10．5：1。结石成分以混合结石占多数，为325例（71％），其中以草酸钙，磷酸钙与尿酸的混合结石为主。对比混合性结石及单纯性结石发现，各种成分所占比例基本一致。结论结石成分分析对于了解结石成因、预防结石形成和复发具有重要的意义。