全文获取类型
收费全文 | 2550篇 |
免费 | 216篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 62篇 |
妇产科学 | 35篇 |
基础医学 | 367篇 |
口腔科学 | 78篇 |
临床医学 | 223篇 |
内科学 | 663篇 |
皮肤病学 | 24篇 |
神经病学 | 249篇 |
特种医学 | 90篇 |
外国民族医学 | 5篇 |
外科学 | 328篇 |
综合类 | 38篇 |
一般理论 | 6篇 |
预防医学 | 266篇 |
眼科学 | 26篇 |
药学 | 163篇 |
中国医学 | 3篇 |
肿瘤学 | 137篇 |
出版年
2023年 | 25篇 |
2022年 | 32篇 |
2021年 | 54篇 |
2020年 | 31篇 |
2019年 | 37篇 |
2018年 | 62篇 |
2017年 | 44篇 |
2016年 | 44篇 |
2015年 | 42篇 |
2014年 | 72篇 |
2013年 | 116篇 |
2012年 | 149篇 |
2011年 | 157篇 |
2010年 | 87篇 |
2009年 | 65篇 |
2008年 | 142篇 |
2007年 | 146篇 |
2006年 | 140篇 |
2005年 | 114篇 |
2004年 | 109篇 |
2003年 | 93篇 |
2002年 | 107篇 |
2001年 | 64篇 |
2000年 | 65篇 |
1999年 | 50篇 |
1998年 | 38篇 |
1997年 | 23篇 |
1996年 | 21篇 |
1995年 | 31篇 |
1994年 | 23篇 |
1993年 | 25篇 |
1992年 | 62篇 |
1991年 | 54篇 |
1990年 | 56篇 |
1989年 | 40篇 |
1988年 | 41篇 |
1987年 | 33篇 |
1986年 | 17篇 |
1985年 | 21篇 |
1984年 | 15篇 |
1983年 | 19篇 |
1982年 | 16篇 |
1981年 | 13篇 |
1979年 | 20篇 |
1978年 | 15篇 |
1976年 | 11篇 |
1974年 | 14篇 |
1973年 | 13篇 |
1971年 | 11篇 |
1970年 | 12篇 |
排序方式: 共有2776条查询结果,搜索用时 31 毫秒
51.
Preventive health remains at the forefront of public health concerns; recent initiatives, such as the NHS health check, may lead to recommendations for medication in response to the identification of ‘at risk’ individuals. Little is known about lay views of preventive medication. This paper uses the case of aspirin as a prophylactic against heart disease to explore views among people invited to screening for a trial investigating the efficacy of such an approach. Qualitative interviews (N = 46) and focus groups (N = 5, participants 31) revealed dilemmas about preventive medication in the form of clashes between norms: first, in general terms, assumptions about the benefit of prevention were complicated by dislike of medication; second, the individual duty to engage in prevention was complicated by the need not to be over involved with one's own health; third, thepotential appeal of this alternative approach to health promotion was complicated by unease about the implications of encouraging irresponsible behaviour among others. Though respondents made different decisions about using the drug, they reported very similar ways of trying to resolve these conflicts,drawing upon concepts of necessity and legitimisation and the special ordinariness of the particular drug. 相似文献
52.
Age and Prevalence of Cervical Carcinoma in Subsequent Hysterectomy Following a Conization Procedure
53.
Clarke JL Vulliamy TJ Roper D Mesbah-Namin SA Wild BJ Walker JI Will AM Bolton-Maggs PH Mason PJ Layton DM 《Blood cells, molecules & diseases》2003,30(3):258-263
Glucosephosphate isomerase (GPI) deficiency in humans is an autosomal recessive disorder, which results in nonspherocytic hemolytic anemia of variable clinical expression. A 4-year-old female with severe congenital hemolytic anemia had low red cell GPI activity of 15.5 IU/g Hb (50% of normal mean) indicating GPI deficiency. Subsequent DNA sequence analysis revealed a novel homozygous 921C to G mutation in the GPI gene sequence, predicting a Phe307 to Leu replacement. Strikingly, the red cell GPI activity in this patient was higher than that found in a second patient expressing the same GPI variant, with a more severe clinical phenotype. We propose that the hemolysis in the first patient may be modified by an accompanying deficiency of glucose-6-phosphate dehydrogenase (G6PD). The proband's red cell G6PD activity was reduced at 4.5 IU/g Hb (50% of normal mean) and molecular studies revealed heterozygosity for the G6PD Viangchan mutation and a skewed pattern of X-chromosome inactivation, producing almost exclusive expression of the mutated allele. The G6PD Viangchan variant is characterised by severe enzyme deficiency, but not chronic hemolysis. This study suggests that the metabolic consequences of a combined deficiency of GPI and G6PD might be responsible for a different clinical outcome than predicted for either defect in isolation. 相似文献
54.
55.
L Theilmann K Gmelin H Will P Czygan M Roggendorf B Kommerell 《The Journal of infectious diseases》1984,150(1):118-120
Hepatitis B virus (HBV) DNA was detected in 17 sera positive for antibody to delta antigen (anti-delta). Six sera from two patients were positive for HBV DNA. Analysis by the Southern blot technique showed identity between HBV DNA in anti-delta-positive and anti-delta-negative sera. These results show that anti-delta-positive sera contain HBV DNA, although these sera were also positive for antibodies to hepatitis B e antigen. 相似文献
56.
57.
58.
Chronic hepatitis C virus (HCV) infection is a well-recognized risk factor for hepatocellular carcinoma (HCC). As a co-risk factor, the role of tobacco use in HCV-driven carcinogenesis and relevant underlying mechanisms remain largely unclear. The latest discoveries about HCV replication have shown that HCV RNA hijacks cellular miRNA-122 by forming an Ago2-HCV-miR-122 complex that stabilizes the HCV genome and enhances HCV replication. Our previous work has demonstrated that aqueous tobacco smoke extract (TSE) is a potent activator of HIV replication via TSE-mediated viral protection from oxidative stress and activation of a set of genes that can promote viral replication. Since HCV is, like HIV, an enveloped virus that should be equally susceptible to lipid peroxidation, and since one of the TSE-upregulated genes, the DDX3 helicase, is known to facilitate HCV replication, we hypothesize that (1) tobacco use can similarly enhance HCV viability and replication, and promote HCC progression by up-regulation of DDX3, and (2) by competing for binding with miR-122 as a competing endogenous RNA (ceRNA), HCV replication can liberate miR-122’s direct target, oncogenic gene cyclin G1 (CCNG1); furthermore, simultaneous tobacco use can synergistically enhance this competing effect via HCV upregulation. Our hypotheses may lay a foundation for better understanding of carcinogenesis in HCV-driven HCC and the potential role of tobacco as a cofactor. Disrupting the HCV ceRNA effect may provide a new strategy for designing anti HCV/HCC drugs. 相似文献
59.
60.
Stavros M Stivaros Robert Alston Neville B Wright Kate Chandler Denise Bonney Robert F Wynn Andrew M Will Maqsood Punekar Sean Loughran John-Paul Kilday Detlev Schindler Leena Patel Stefan Meyer 《The British journal of radiology》2015,88(1056)