全文获取类型
收费全文 | 303篇 |
免费 | 12篇 |
国内免费 | 8篇 |
专业分类
儿科学 | 11篇 |
妇产科学 | 4篇 |
基础医学 | 37篇 |
口腔科学 | 5篇 |
临床医学 | 51篇 |
内科学 | 46篇 |
皮肤病学 | 8篇 |
神经病学 | 8篇 |
特种医学 | 93篇 |
外科学 | 21篇 |
综合类 | 5篇 |
预防医学 | 9篇 |
眼科学 | 2篇 |
药学 | 20篇 |
肿瘤学 | 3篇 |
出版年
2021年 | 2篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2017年 | 1篇 |
2015年 | 3篇 |
2014年 | 6篇 |
2013年 | 3篇 |
2012年 | 7篇 |
2011年 | 4篇 |
2010年 | 20篇 |
2009年 | 11篇 |
2008年 | 9篇 |
2007年 | 12篇 |
2006年 | 15篇 |
2005年 | 10篇 |
2004年 | 5篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1998年 | 18篇 |
1997年 | 19篇 |
1996年 | 13篇 |
1995年 | 11篇 |
1994年 | 13篇 |
1993年 | 13篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 9篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 10篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 7篇 |
1981年 | 2篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 7篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1972年 | 2篇 |
排序方式: 共有323条查询结果,搜索用时 15 毫秒
191.
192.
Zhanel GG Adam HJ Low DE Blondeau J Decorby M Karlowsky JA Weshnoweski B Vashisht R Wierzbowski A Hoban DJ;Canadian Antimicrobial Resistance Alliance 《Diagnostic microbiology and infectious disease》2011,69(3):291-306
The CANWARD study (Canadian Ward Surveillance Study) assessed the antimicrobial susceptibility of a variety of available agents against 15 644 pathogens isolated from patients in Canadian hospitals between 2007 and 2009. The most active (based on MIC data) agents against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci were daptomycin, linezolid, tigecycline, and vancomycin (MRSA only) with MIC(90)'s (μg/mL) of 0.25 and 2, 2 and 2, 0.5 and 0.12, and 1, respectively. The most active agents against extended-spectrum β-lactamase-producing Escherichia coli were colistin (polymyxin E), doripenem, ertapenem, meropenem, and tigecycline with MIC(90)'s (μg/mL) of 1, ≤ 0.12, 0.25, ≤ 0.12, and 1, respectively. The most active agents against Pseudomonas aeruginosa were amikacin, cefepime, ceftazidime, colistin, doripenem, meropenem, and piperacillin-tazobactam with MIC(90)'s (μg/mL) of 32, 16, 32, 2, 4, 8, and 64, respectively. Overall, the most active agents versus Gram-positive cocci from Canadian hospitals were vancomycin, linezolid, daptomycin, and tigecycline and versus Gram-negative bacilli were amikacin, cefepime, doripenem, ertapenem (excluding Pseudomonas aeruginosa), meropenem, piperacillin-tazobactam, and tigecycline (excluding Pseudomonas aeruginosa). 相似文献
193.
目的评估磁共振弥散加权成像(DWI)和灌注加权成像(PWI)诊断急性缺血性卒中的临床证据方法系统性分析1966年-2008年1月的文献,探讨DWI和PWI在急性缺血性卒中诊断和预后判断方面的价值.结果和推荐意见DWI是诊断急性缺血性卒中的有效手段。在卒中首发症状出现12h内,DWI的诊断价值优于CT平扫。DWI能够最准确地诊断急性缺血性卒中(A级推荐);但DWI的敏感件存诊断普通人群疑似卒中时,并不是最佳。本指南并不讨论DWI对脑出血的诊断价值,Ⅱ级和Ⅲ级证据的研究显示,根据苯线DWI上病灶大小,顺洲前循环卒中早期病情严重程度的价值较高(B纵推荐),对后循环率中似乎缺乏预测价值(C级推荐)。基线DWI上病灶大小可预测最终梗死灶的大小(B级推荐)及早期、后期的临床转归(C级推荐):与DWI相比,基线PWI上病灶大小对病情严重释度的预测价值较低(C纵推荐)。目前尚无足够的证据支持或否定PWI对急性缺血性卒中的诊断价值(U级推荐), 相似文献
194.
Zhanel GG DeCorby M Nichol KA Wierzbowski A Baudry PJ Karlowsky JA Lagacé-Wiens P Walkty A Mulvey MR Hoban DJ;Canadian Antimicrobial Resistance Alliance 《Diagnostic microbiology and infectious disease》2008,62(1):67-80
We tested the in vitro activity of 15 antimicrobials against Gram-positive cocci and 12 antimicrobials against Gram-negative bacilli versus 3931 isolates (20 most common organisms) obtained between September 1, 2005, and June 30, 2006, from 19 intensive care units (ICUs) across Canada. The most active (based upon MIC only) agents against methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis were dalbavancin, daptomycin, linezolid, tigecycline, and vancomycin with MIC(90) (microg/mL) of 0.06 and < or =0.03, 0.25 and 0.12, 2 and 1, 0.5 and 0.5, and 1 and 2, respectively. The most active agents against vancomycin-resistant enterococci were daptomycin, linezolid, and tigecycline with MIC(90) (microg/mL) of 1, 4, and 0.12, respectively. The most active agents against Escherichia coli were amikacin, cefepime, meropenem, piperacillin/tazobactam, and tigecycline with MIC(90) (microg/mL) of 4, < or =1, < or =0.12, 8, and 0.5, respectively. The most active agents against extended-spectrum beta-lactamase-producing E. coli were meropenem and tigecycline with MIC(90) (microg/mL) of < or =0.12 and 1, respectively. The most active agents against Pseudomonas aeruginosa were amikacin, cefepime, meropenem, and piperacillin/tazobactam with MIC(90) (microg/mL) of 16, 32, 16, and 64, respectively. The most active agents against Stenotrophomonas maltophilia were tigecycline and trimethoprim/sulfamethoxazole with MIC(90) (microg/mL) of 4 and 4, respectively. The most active agents against Acinetobacter baumannii were fluoroquinolones (e.g., levofloxacin), meropenem, and tigecycline with MIC(90) (microg/mL) of 0.5, 1, and 2, respectively. In conclusion, the most active agents versus Gram-positive cocci and Gram-negative bacilli obtained from Canadian ICUs were daptomycin, linezolid, tigecycline, dalbavancin and amikacin, cefepime, meropenem, piperacillin/tazobactam, and tigecycline (not P. aeruginosa), respectively. 相似文献
195.
196.
197.
LG Chicoine CL Montgomery WG Bremer KM Shontz DA Griffin KN Heller S Lewis V Malik WE Grose CJ Shilling KJ Campbell TJ Preston BD Coley PT Martin CM Walker KR Clark Z Sahenk JR Mendell LR Rodino-Klapac 《Molecular therapy》2014,22(2):338-347
Duchenne muscular dystrophy is a monogenic disease potentially treatable by gene replacement. Use of recombinant adeno-associated virus (AAV) will ultimately require a vascular approach to broadly transduce muscle cells. We tested the impact of preexisting AAV antibodies on microdystrophin expression following vascular delivery to nonhuman primates. Rhesus macaques were treated by isolated limb perfusion using a fluoroscopically guided catheter. In addition to serostatus stratification, the animals were placed into one of the three immune suppression groups: no immune suppression, prednisone, and triple immune suppression (prednisone, tacrolimus, and mycophenolate mofetil). The animals were analyzed for transgene expression at 3 or 6 months. Microdystrophin expression was visualized in AAV, rhesus serotype 74 sero-negative animals (mean: 48.0 ± 20.8%) that was attenuated in sero-positive animals (19.6 ± 18.7%). Immunosuppression did not affect transgene expression. Importantly, removal of AAV binding antibodies by plasmapheresis in AAV sero-positive animals resulted in high-level transduction (60.8 ± 18.0%), which is comparable with that of AAV sero-negative animals (53.7 ± 7.6%), whereas non-pheresed sero-positive animals demonstrated significantly lower transduction levels (10.1 ± 6.0%). These data support the hypothesis that removal of AAV binding antibodies by plasmapheresis permits successful and sustained gene transfer in the presence of preexisting immunity (natural infection) to AAV. 相似文献
198.
199.
FM Freitag TF Cestari LR Leopoldo P Paludo JC Boza 《Journal of the European Academy of Dermatology and Venereology》2008,22(6):655-662
Background Melasma can cause a significant effect on individual emotional well‐being. Melasma Quality of Life Scale (MELASQoL) is a specific questionnaire elaborated to assess the burden of melasma on patient's quality of life. Objective To evaluate the clinical aspects, severity and the influence of melasma on daily living of a sample of Brazilian women. Methods Cross‐sectional study that enrolled 85 women with melasma older than 15 years of age. Trained investigators asked 55 questions to collect epidemiological and clinical data. The disease severity was clinically assessed using Melasma Area and Severity Index (MASI). Patients answered the Portuguese version of 10‐item MELASQoL scale without coaching. Results The mean ± SD age was 41.1 ± 6.8 years, and the mean ± SD of MELASQoL score was 37.5 ± 15.2 (median, 35). Patients with previous psychiatric diagnosis had significantly higher MELASQoL scores (mean, 42.8; SD, 13.6) than patients without this antecedent (mean, 35.4; SD, 15.4; P < 0.05). Patients with less than 8 years of school attendance also had significantly higher MELASQoL score (mean, 44; SD, 16.9) than more graduated ones (mean, 34.4; SD, 13.5; P < 0.05). The mean ± SD MASI was 10.6 ± 6.6 (median, 10.2). There was no correlation between MASI and MELASQoL. Conclusions This study confirms that MELASQoL‐BP is easy to administer, adds important information about the impact of melasma on South American women's life and, finally, contributes to building evidence on the validity, reliability and cultural adaptation of the Portuguese language MELASQoL version. 相似文献
200.
Lung nodule enhancement at CT: prospective findings 总被引:67,自引:0,他引:67