全文获取类型
收费全文 | 2323篇 |
免费 | 233篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 57篇 |
妇产科学 | 82篇 |
基础医学 | 335篇 |
口腔科学 | 19篇 |
临床医学 | 308篇 |
内科学 | 438篇 |
皮肤病学 | 98篇 |
神经病学 | 203篇 |
特种医学 | 54篇 |
外科学 | 236篇 |
综合类 | 42篇 |
预防医学 | 320篇 |
眼科学 | 28篇 |
药学 | 130篇 |
中国医学 | 1篇 |
肿瘤学 | 188篇 |
出版年
2023年 | 21篇 |
2022年 | 37篇 |
2021年 | 71篇 |
2020年 | 52篇 |
2019年 | 96篇 |
2018年 | 76篇 |
2017年 | 55篇 |
2016年 | 69篇 |
2015年 | 77篇 |
2014年 | 113篇 |
2013年 | 111篇 |
2012年 | 177篇 |
2011年 | 191篇 |
2010年 | 77篇 |
2009年 | 66篇 |
2008年 | 128篇 |
2007年 | 107篇 |
2006年 | 115篇 |
2005年 | 103篇 |
2004年 | 106篇 |
2003年 | 75篇 |
2002年 | 53篇 |
2001年 | 41篇 |
2000年 | 51篇 |
1999年 | 31篇 |
1998年 | 13篇 |
1997年 | 15篇 |
1995年 | 13篇 |
1994年 | 11篇 |
1992年 | 24篇 |
1991年 | 23篇 |
1990年 | 20篇 |
1989年 | 26篇 |
1988年 | 16篇 |
1987年 | 29篇 |
1986年 | 22篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 10篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1979年 | 20篇 |
1978年 | 11篇 |
1977年 | 9篇 |
1975年 | 10篇 |
1974年 | 9篇 |
1973年 | 8篇 |
1972年 | 8篇 |
1970年 | 8篇 |
1966年 | 12篇 |
排序方式: 共有2561条查询结果,搜索用时 31 毫秒
991.
992.
993.
994.
995.
996.
Lasater EA Bessler WK Mead LE Horn WE Clapp DW Conway SJ Ingram DA Li F 《Human molecular genetics》2008,17(15):2336-2344
Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the NF1 tumor suppressor gene. Neurofibromin is encoded by NF1 and functions as a negative regulator of Ras activity. Somatic mutations in the residual normal NF1 allele within cancers of NF1 patients is consistent with NF1 functioning as a tumor-suppressor. However, the prevalent non-malignant manifestations of NF1, including learning and bone disorders emphasize the importance of dissecting the cellular and biochemical effects of NF1 haploinsufficiency in multiple cell lineages. One of the least studied complications of NF1 involves cardiovascular disorders, including arterial occlusions that result in cerebral and visceral infarcts. NF1 vasculopathy is characterized by vascular smooth muscle cell (VSMC) accumulation in the intima area of vessels resulting in lumen occlusion. We recently showed that Nf1 haploinsufficiency increases VSMC proliferation and migration via hyperactivation of the Ras-Erk pathway, which is a signaling axis directly linked to neointima formation in diverse animal models of vasculopathy. Given this observation, we tested whether heterozygosity of Nf1 would lead to vaso-occlusive disease in genetically engineered mice in vivo. Strikingly, Nf1+/- mice have increased neointima formation, excessive vessel wall cell proliferation and Erk activation after vascular injury in vivo. Further, this effect is directly dependent on a Gleevec sensitive molecular pathway. Therefore, these studies establish an Nf1 model of vasculopathy, which mirrors features of human NF1 vaso-occlusive disease, identifies a potential therapeutic target and provides a platform to further dissect the effect of Nf1 haploinsufficiency in cardiovascular disease. 相似文献
997.
Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity 总被引:1,自引:0,他引:1
998.
Zhu JJ Gerstner ER Engler DA Mrugala MM Nugent W Nierenberg K Hochberg FH Betensky RA Batchelor TT 《Neuro-oncology》2009,11(2):211-215
The introduction of methotrexate (MTX)-based chemotherapy has improved median survival for patients with primary CNS lymphoma (PCNSL). Older age is a negative prognostic marker in patients with PCNSL and may increase the likelihood of MTX toxicity. We studied the response and adverse effects of intravenous high-dose MTX in patients who were 70 or more years of age at the time of diagnosis. We identified 31 patients at our institution diagnosed with PCNSL at age > or =70 years (median, 74 years) who were treated with high-dose MTX (3.5-8 g/m(2)) as initial therapy from 1992 through 2006. The best response to MTX was determined by contrast-enhanced MRI. Toxicity was analyzed by chart review. These 31 patients received a total of 303 cycles of MTX (median, eight cycles per patient). Overall, 87.9% of the cycles required dose reduction because of impaired creatinine clearance. In 30 evaluable patients, the overall radiographic response rate was 96.7%, with 18 complete responses (60%) and 11 partial responses (36.7%). Progression-free survival and overall survival were 7.1 months and 37 months, respectively. Grade I-IV toxicities were observed in 27 of 31 patients and included gastrointestinal disturbances in 58% (3.2% grade III), hematological complications in 80.6% (6.5% grade III), and renal toxicity in 29% (0% grade III/IV). High-dose MTX is associated with a high proportion of radiographic responses and a low proportion of grade III/IV toxicity in patients 70 or more years of age. High-dose MTX should be considered as a feasible treatment option in elderly patients with PCNSL. 相似文献
999.
Gara N Falzarano JS Limm WM Namiki TS Tom LK 《World journal of gastrointestinal oncology》2009,1(1):89-92
Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract. While mostly reported as solitary gastric lesions, multiple cases of small bowel IFPs are also reported. It is a documented cause of intussusception in adults. In the case reports of ileal inflammatory fibroid polyps with intussusception, an emergent presentation with small bowel obstruction has been most often described. Here we depict a case of ileal inflammatory fibroid polyp presenting with chronic intermittent ileocolic intussusception, anemia and weight loss with an endoscopic appearance mimicking necrotic cecal carcinoma. 相似文献