全文获取类型
收费全文 | 2181篇 |
免费 | 153篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 194篇 |
妇产科学 | 19篇 |
基础医学 | 248篇 |
口腔科学 | 60篇 |
临床医学 | 210篇 |
内科学 | 513篇 |
皮肤病学 | 28篇 |
神经病学 | 76篇 |
特种医学 | 484篇 |
外科学 | 178篇 |
综合类 | 45篇 |
预防医学 | 101篇 |
眼科学 | 16篇 |
药学 | 85篇 |
中国医学 | 3篇 |
肿瘤学 | 89篇 |
出版年
2022年 | 9篇 |
2021年 | 17篇 |
2020年 | 18篇 |
2019年 | 25篇 |
2018年 | 37篇 |
2017年 | 16篇 |
2016年 | 27篇 |
2015年 | 37篇 |
2014年 | 33篇 |
2013年 | 77篇 |
2012年 | 46篇 |
2011年 | 47篇 |
2010年 | 95篇 |
2009年 | 68篇 |
2008年 | 55篇 |
2007年 | 52篇 |
2006年 | 46篇 |
2005年 | 44篇 |
2004年 | 31篇 |
2003年 | 36篇 |
2002年 | 34篇 |
2001年 | 29篇 |
2000年 | 32篇 |
1999年 | 43篇 |
1998年 | 140篇 |
1997年 | 122篇 |
1996年 | 129篇 |
1995年 | 99篇 |
1994年 | 77篇 |
1993年 | 86篇 |
1992年 | 36篇 |
1991年 | 26篇 |
1990年 | 31篇 |
1989年 | 72篇 |
1988年 | 52篇 |
1987年 | 62篇 |
1986年 | 53篇 |
1985年 | 52篇 |
1984年 | 27篇 |
1983年 | 37篇 |
1982年 | 38篇 |
1981年 | 21篇 |
1980年 | 37篇 |
1979年 | 31篇 |
1978年 | 27篇 |
1977年 | 21篇 |
1976年 | 28篇 |
1975年 | 30篇 |
1968年 | 11篇 |
1967年 | 12篇 |
排序方式: 共有2356条查询结果,搜索用时 9 毫秒
101.
Sven Goetstouwers Dagmar Kempink Bertram The Denise Eygendaal Bart van Oirschot Christiaan JA van Bergen 《World journal of orthopedics》2022,13(1):1-10
Three-dimensional (3D) printing is a rapidly evolving and promising field to improve outcomes of orthopaedic surgery. The use of patient-specific 3D-printed models is specifically interesting in paediatric orthopaedic surgery, as limb deformity corrections often require an individual 3D treatment. In this editorial, various operative applications of 3D printing in paediatric orthopaedic surgery are discussed. The technical aspects and the imaging acquisition with computed tomography and magnetic resonance imaging are outlined. Next, there is a focus on the intraoperative applications of 3D printing during paediatric orthopaedic surgical procedures. An overview of various upper and lower limb deformities in paediatrics is given, in which 3D printing is already implemented, including post-traumatic forearm corrections and proximal femoral osteotomies. The use of patient-specific instrumentation (PSI) or guiding templates during the surgical procedure shows to be promising in reducing operation time, intraoperative haemorrhage and radiation exposure. Moreover, 3D-printed models for the use of PSI or patient-specific navigation templates are promising in improving the accuracy of complex limb deformity surgery in children. Lastly, the future of 3D printing in paediatric orthopaedics extends beyond the intraoperative applications; various other medical applications include 3D casting and prosthetic limb replacement. In conclusion, 3D printing opportunities are numerous, and the fast developments are exciting, but more evidence is required to prove its superiority over conventional paediatric orthopaedic surgery. 相似文献
102.
Miguel JA Láinez 《Neuropsychiatric Disease and Treatment》2006,2(3):247-259
Migraine is a common, disabling disorder associated with considerable personal and societal burden. Current guidelines recommend triptans for the acute treatment of migraine unlikely to respond to less effective therapies. Rizatriptan is a second-generation triptan available in tablet or orally disintegrating tablet (wafer) formulations that offers several advantages over other members of its class. Rizatriptan is rapidly absorbed from the gastrointestinal tract and achieves maximum plasma concentrations more quickly than other triptans, providing rapid pain relief. Clinical trials have shown that rizatriptan is at least as effective or superior to other oral migraine-specific agents in the acute treatment of migraine, and has more consistent long-term efficacy across multiple migraine attacks. Rizatriptan has a favorable tolerability profile, and patients have reported greater satisfaction and a preference for rizatriptan over other migraine-specific agents. Improvements in quality of life reported with rizatriptan are consistent with its favorable efficacy and tolerability profiles. Notably, multi-attribute decision models that combine clinical data with patient- and physician-reported treatment preferences have identified rizatriptan as one of three triptans closest to a hypothetical “ideal”. The efficacy and tolerability of rizatriptan for the acute treatment of migraine have thus been well established. 相似文献
103.
Nemandra Sandiford SK Muirhead-Allwood JA Skinner 《Indian Journal of Orthopaedics》2015,49(6):595-601
Background:
Hip resurfacing arthroplasty (HRA) is primarily indicated for young, active patients with disabling coxarthrosis who wish to remain active and return to sports after surgery. Relatively few prospective studies have assessed return to sporting activity and impact of gender and age on this.Materials and Methods:
Seventy-nine consecutive patients treated with HRA were included. Patients were reviewed clinically and radiologically. Function was assessed using the modified University of California Los Angeles (UCLA) activity score. The Oxford, Harris and WOMAC hip scores were calculated.Results:
Average age at the time of surgery was 54.9 years (range 34.5–73.6 years). Average preoperative and postoperative UCLA scores were 4 and 7.6 respectively. Patients were involved in 2 (0–4) sporting activities preoperatively and 2 (0–5) postoperatively. Preoperative and postoperative Oxford Hip Scores, Harris Hip Score and WOMAC scores were 40, 46 and 51 and 16, 94 and 3 respectively (P < 0.0001). Patients returned to sports at an average of 3 months postoperatively.Conclusion:
Patients were able to return to sports by 3 months and perform the same number of activities at preoperative intensity. Activity levels are maintained up to the medium term with few complications. 相似文献104.
Chris L. McGowin Gregory C. Whitlock Richard B. Pyles 《Diagnostic microbiology and infectious disease》2009
Chlamydia trachomatis (CT) is the most prevalent sexually transmitted bacterial pathogen worldwide and causes severe reproductive tract infections. Currently, nucleic acid amplification tests (NAATs) are the gold standard for clinical diagnosis, but most NAATs are labor intensive and limited to specific CT serovars. We developed and validated a quantitative polymerase chain reaction (qPCR) assay that reproducibly detected CT serovars D, E, F, Ia, and Chlamydia muridarum over a linear range of 2 log10 to 10 log10 genomes with low coefficients of variation from both experimental and human urine samples. CT DNA loads from human vaginal, endocervical, and male urethral swabs correlated well with the BD ProbeTec ET assay (Becton Dickinson Diagnostic Systems, Franklin Lakes, NJ) run in parallel. In a preclinical microbicide evaluation, C. muridarum DNA loads in mouse swabs and tissues correlated well with an immunofluorescence assay. The optimized qPCR system provided enhanced sensitivity and facilitated the quantitative evaluation of clinical and experimental preclinical samples for anti-CT therapeutic and microbicide evaluation. 相似文献
105.
106.
107.
Dios Castro E Maquet Dusart JA 《Archivos de la Sociedad Espa?ola de Oftalmología》2000,75(11):775-778
PURPOSE/METHOD: We present a case of a patient who developed recurrent epithelial herpes simplex keratitis after starting treatment with latanoprost. Her ophthalmic history was only remarkable for a past episode of herpetic keratitis 21 years previously. RESULTS/CONCLUSIONS: Episodes of herpetic keratitis were under remission only when latanoprost was discontinued. No recurrences of herpes simplex keratitis have been observed since then. Latanoprost usage might be associated with recurrent episodes of herpes simplex keratitis in patients with previous history of ocular herpes simplex virus infection. 相似文献
108.
109.
We report a case of successful treatment of a severely diseased saphenous vein graft from the transradial approach. Initial rheolytic thrombectomy was performed followed by coronary stenting through a 6 French guide catheter. Continuing miniaturization of interventional devices increases the utility of the transradial approach. 相似文献
110.
Monge-Argiles J Maloteaux J Van Den Bergh P Sindic C 《Neurología (Barcelona, Spain)》2002,17(2):110-112
We report a patient with a peripheral neuropathy as the first symptom of sarcoidosis. The systemic illness was proved by the presence of typic granulomes in the bone marrow. The fact that sarcoidosis is the cause for the neuropathy is supported by the temporary relation and by the good response of all clinical picture to the corticosteroid therapy.Sarcoid neuropathy can rarely be the presenting feature of sarcoidosis. 相似文献