1020例不孕症的子宫及输卵管形态学分析

用复方泛影葡胺注射液对1,020例不孕症者作子宫输卵管造影。结果:子宫腔形态异常540例。双侧输卵管通畅但形态异常者268例。单侧输卵管通畅但形态异常者110例。结果表明:子宫输卵管形态异常与不孕有密切关系。     

异体硬脊膜桥接周围神经缺损的实验研究

探讨异体硬脊膜修复周围神经缺损的可行性。方法：采用狗的异体硬脊膜桥接缺损２ｃｍ的狗腓总神经，对照组仅切取２ｃｍ神经而不作处理。在术后不同时间段作大体观察、神经电生理检测、光镜利电镜检查。结果：再生神经纤维在管腔内呈纵行整齐排列Ｔ偕窬宋峤岣弧＝崧郏菏5验结果证实异体硬脊膜能成功地引导周围神经再生。     

脑出血患者血浆及脑脊液内皮素－1含量对照研究

本文对照研究了脑出血患者血浆及脑脊液（ＣＳＦ）内皮素－１（ＥＴ－１）含量改变及其临床意义。发现脑出血患者血浆与ＣＳＦ、ＥＴ－１含量均增高；单纯脑血肿者以血浆含量增高为主；脑实质出血伴有脑室系统或蛛网膜下腔出血（ＳＡＨ）者血浆及ＣＳＦ含量均显著升高；小量出血与中大量出血比较血浆含量无显著性，而大量出血者ＣＳＦ、ＥＴ－１含量增高。提示脑出血者血浆ＥＴ－１增高可能与机体应激有关，而ＣＳＦ、ＥＴ－１升高可能与血脑屏障（ＢＢＢ）被破坏及损害或刺激室周组织、下丘脑、脉络丛脑膜，引起分泌释放增加有关。ＣＳＦ、ＥＴ－１增高者应警惕迟发性脑血管痉挛。     

红色素基因RFLP及其与情感性精神病关系的研究

以红色素基因全长ｃＤＮＡ作探针，２０例正常人，２６例双相型情感性精神病患者进行ＲＦＬＰ分析。ＳａｃＩ酶切显示：部分正常人和部分患者基因组ＤＮＡ产生的７．５ｋｂ，４．８ｋｂ，４．５ｋｂ呈多态性改变的片段。正常人具多态改变的占４５％，患者为４６．２％，按Ｘ染色体数计，正常人出现７．５ｋｂ限制性片段的频率为１４．３％，患者为３２．４％，但两者差异不显著。     

L－缬氨酸菌种选育

以硫酸二乙酯（ＤＥＳ）诱变处理黄色短杆菌（Ｂｒｅｖｉｂａｃｔｅｒｉｕｍｆｌａｖｕｍ）ＸＱ５１２２，得到突变株Ｖ３－３６＜Ｌｅｕ￣１、α－ＡＢ￣ｒ、ＡＨＶ￣ｒ），在１０％葡萄糖培养基中可积累２．３％Ｌ－缬氨酸。以亚硝基胍（ＮＴＧ）诱变Ｖ４－１５３，得到一株突变株（Ｌｅｕ￣１、α－ＡＢ￣ｒ、ＡＨＶ￣ｒ、２－ＴＡ￣ｒ），再进行单菌落分离，得到突变株ＺＱ－２，能在培养基中积累Ｌ－缬氨酸４．２％～４．５％，最高达５．５７％．     

回结肠造瘘术后并发症原因分析

总结１９８７年至１９９５年回结肠造瘘术６３例，发生并发症３５例，分析原因认为回结肠造瘘术系为解决肠道梗阻、外伤或肠切除术的第１期手术而进行的暂时或永久的粪便转流术，在许多情况下可挽救病人的生命，然而，处理不当亦可发生严重并发症，甚至导致死亡。其中以瘘口周围炎、瘘口狭窄为最常见，瘘口出血及肠坏死后果最为严重。防止并发症的关键是手术应规范化，提高对各种并发症的警惕性及较好的术后护理。     

法乐四联症右室心肌超微结构定量测量与临床的对比研究

为探讨法乐四联症（Ｆ_４）右室心肌超微结构的不同表现与Ｆ_４术前各项临床检查及术后心功能的关系，作者对室间隔缺损组（Ⅰ组，１１例），儿童Ｆ_４组（Ⅱ组，１３例）和成人Ｆ_４组（Ⅲ组，１３例）进行比较，用Ｓｙｓｔａｔ计算机统计软件作多因素方差分析和Ｐｅａｒｓｏｎ相关研究。结果见Ⅱ、Ⅲ组病人的ＰＯ_２仅和核浆比有关，Ｐ_（ＲＶ）与细胞的核体密度、横径、核浆比及肥大肌细胞比率明显有关，肥大肌细胞比率与病人年龄及ＰａＯ_２明显相关。作者认为Ｆ_４病人右室心肌超微结构改变主要系右室压力增高所致，这种改变与年龄有关。     

改良输卵管宫角植入术在结扎术后输卵管近段病理性闭塞复通中的应用探讨

对60例输卵管结扎术后近段闭塞(间质部及峡部)妇女采用改良输卵管子宫角植入术,并对部分病例切除的近段输卵管标本进行病理形态学观察。病理检查发现:①输卵管慢性炎症;②输卵管子宫内膜异位症;③管腔内增生的纤维组织填塞。术后随访50例(83.33％),输卵管通畅46例(92％),宫内妊娠29例(58％),校正妊娠率为63.04％,宫外孕1例,表明宫角植入术用于此类结扎术后输卵管近段闭塞病例的复通有较好疗效。对此术式的关键点及术后宫内妊娠率与绝育年限、年龄、术后输卵管长度的关系作了分析。     

双酚胺酸对小鼠和大鼠氯化镍解毒及分布的影响

AIM: To study the effect of catecholamic acid (CBMIDA) on detoxication of NiCl2. METHODS: Mice and rats were injected s.c. or i.m. CBMIDA immediately after i.p. NiCl2. Each mouse was injected i.p. CBMIDA after i.v. 63NiCl2 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h. The localization of 63Ni was shown by the whole-body autoradiography. RESULTS: CBMIDA s.c. 0.5-1.5 g.kg-1 markedly reduced the mortality from acute poisoning of i.p. NiCl2 500 mg.kg-1. After i.p. NiCl2 in mice, the LD50 was 82.7 mg.kg-1. Mice were injected s.c. CBMIDA 1.5 or 2.5 g.kg-1 after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg-1, respectively. The LD50 of NiCl2 was 39 mg.kg-1 in rat. If CBMIDA was injected i.m. 0.5 g.kg-1 after i.p. NiCl2, the LD50 was 332 mg.kg-1. CBMIDA 1.5 g.kg-1 i.m. after i.v. 63NiCl2, decreased the contents of 63Ni in blood and lung of mice vs control mice at 24 h. The contents of 63Ni in brain, heart, spleen, and kidney were similar to those of the control mice. The content of 63Ni in bone was more than the control. The excretions of 63Ni through urine and feces were not increased by CBMIDA at 24 h. The whole-body autoradiography showed that the radioactivity was highly localized in the kidney, lung, and Harder's gland. There was a moderate level of 63Ni in the liver, bone, skin, and blood. A pronounced accumulation occurred in the bone. There was a marked reduction of 63Ni in the lung, skin, liver, and blood after i.p. CBMIDA. CONCLUSION: The CBMIDA markedly raised the survival rate of nickel-poisoned mice and rats, and decreased 63Ni levels in lung and blood.     

甲基强的松龙冲击疗法治疗重型脱髓鞘脑病患者的护理

采用大剂量甲基强的松龙治疗脱髓鞘脑病患者１５例。在治疗过程中，积极预防应激性溃疡，加强呼吸道及人工冬眠护理。经５次治疗，１４例症状明显改善。