首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   438篇
  免费   29篇
  国内免费   112篇
耳鼻咽喉   1篇
儿科学   5篇
妇产科学   5篇
基础医学   43篇
口腔科学   3篇
临床医学   110篇
内科学   78篇
皮肤病学   14篇
神经病学   12篇
特种医学   41篇
外科学   28篇
综合类   69篇
一般理论   1篇
预防医学   25篇
眼科学   7篇
药学   85篇
中国医学   15篇
肿瘤学   37篇
  2024年   4篇
  2023年   5篇
  2022年   4篇
  2021年   5篇
  2020年   5篇
  2019年   2篇
  2018年   8篇
  2017年   7篇
  2016年   6篇
  2015年   15篇
  2014年   19篇
  2013年   20篇
  2012年   27篇
  2011年   20篇
  2010年   16篇
  2009年   15篇
  2008年   23篇
  2007年   78篇
  2006年   22篇
  2005年   27篇
  2004年   18篇
  2003年   14篇
  2002年   19篇
  2001年   18篇
  2000年   17篇
  1999年   15篇
  1998年   17篇
  1997年   29篇
  1996年   16篇
  1995年   12篇
  1994年   7篇
  1993年   8篇
  1992年   7篇
  1991年   5篇
  1990年   8篇
  1989年   16篇
  1988年   7篇
  1987年   5篇
  1986年   2篇
  1985年   4篇
  1984年   2篇
  1983年   1篇
  1980年   1篇
  1979年   1篇
  1934年   2篇
排序方式: 共有579条查询结果,搜索用时 15 毫秒
101.
套管针连续臂丛阻滞行断指(肢)再植手术35例   总被引:4,自引:1,他引:3  
李杰  郑恒兴  张英民 《医学争鸣》1999,20(10):844-844
0 引言 臂丛阻滞是上肢手术常用的麻醉方法[1].但这种阻滞方法作用时间短,对于较长时间的上肢手术,因反复穿刺而造成局部损伤较大,神经损伤率增高,患者痛苦增加.断指(肢)再植手术[1]是上肢手术中时间较长者,要求阻滞作用完善.为探讨一种阻滞时间灵活、损伤小、作用确切的麻醉方法,我们受连续硬膜外麻醉的启发[1],摸索出连续臂丛阻滞方法,现介绍如下.1 对象和方法1.1 对象 急诊断指(肢)再植手术35(男28,女7)例,年龄18岁~47岁,均因锐器伤而造成指体离断和上肢远端离断,其中1指离断5例,…  相似文献   
102.
靶向化疗:基因治疗研究的新热点   总被引:3,自引:0,他引:3  
1原文要点作者应用逆转录病毒感染法将目的基因G1CEACDNa及pCD2分别转导入高分泌CEA的大肠癌细胞系(Lovo)中,再分别接种到裸鼠皮下,成瘤后腹腔给予5FC(500mg/kg·d)治疗,疗程40d,结果显示含G1CEACDNa及pCD2逆...  相似文献   
103.
膝骨关节病痛点分布规律初探   总被引:1,自引:0,他引:1  
目的:观察膝骨关节病患者常见膝周压痛点及结筋病灶点的分布规律,以期为临床针刀诊治提供依据。方法:对72例膝骨关节病患者进行膝部触诊检查,确定并统计压痛点及结筋点。结果:共115只患膝,其中102只(占88.70%)患膝有数量不等的压痛点。膝骨关节病患者压痛点主要分布在关节内侧,如髌尖内侧面、鹅足腱、胫骨内侧髁等。髌尖外侧在膝关节外侧中出现频率最高。足六条经筋中足三阴经筋结筋点压痛频率均超过70%,足太阳、足少阳经筋膝周经筋结点压痛频率均在50%以下。结论:膝骨关节病患者膝周压痛点及经筋结筋点有其分布规律,此特征与膝关节解剖学结构及生物力学特性密切相关,这将为针刀临床诊治选择有效治疗点提供依据。  相似文献   
104.
    
BACKGROUND:Linezolid is an effective antibiotic reagent for Gram-positive bacterial infection;its most common side effect is thrombocytopenia.However,the incidence of thrombocytopenia in patients with acute-on-chronic liver failure(ACLF)who underwent linezolid therapy was unclear.The present study was to evaluate the incidence of thrombocytopenia in ACLF and non-ACLF patients treated with linezolid and the risk factors of thrombocytopenia in these patients.METHODS:Thirty-five patients with ACLF who had been subjected to intravenous administration of 600 mg linezolid every 12 hours for more than 7 days were categorized as a ACLF treatment(ACLF-T)group,72 patients without ACLF treated with the same dosage of linezolid were recruited as a non-ACLF treatment(NACLF-T)group,and 70 patients with ACLF without linezolid treatment served as an ACLF control(ACLF-C)group.The incidences of thrombocytopenia in different groups were compared at day 14.Risk factors were investigated using logistic regression analysis.RESULTS:The incidence of thrombocytopenia at day 14 was significantly higher in the ACLF-T group than in the ACLF-C group(20/35 vs 24/70,P=0.025)and in the NACLF-T group(20/35 vs 9/72,P0.001).Multivariate analysis showed that the ratio of platelet count(day 7/day 0)1(OR=10.021;P=0.012) and the baseline platelet count(OR=0.985;P=0.036)were independent risk factors of thrombocytopenia at day 14 of linezolid therapy.CONCLUSIONS:The benefits of linezolid treatment should outweigh the risk of thrombocytopenia in patients with ACLF Moreover,it is necessary to closely monitor the platelet count during linezolid therapy especially in the patients with de creased platelet count at day 7 of linezolid therapy.  相似文献   
105.
106.
目的:观察中药辨证组方对慢性肾小球肾炎CKD3期患者的肾保护作用及安全性。方法:对入组人群采用前瞻、双盲、随机对照的研究方法,将符合方案集(Per-protocol.PP)的315例患者分成中药辨证组(158例)和西药苯那普利组(157例)。中药组按肾气阴两虚、肾络瘀痹、风湿扰肾、湿热内蕴四证予中药辨证组方+苯那普利模拟剂+基础治疗;西药组予西药苯那普利10 mg/d+中药组方模拟剂+基础治疗,观察24 h尿蛋白定量(u-pr/24 h)、尿白蛋白/肌酐比值(U-Alb/Cr)、血肌酐(Scr)、尿素氮(Bun)、尿酸(UA)、钾(K+)、估测肾小球滤过率(eGFR·MDRD公式)、CKD分期、中医证候与症状积分值、综合疗效分析及安全性。疗程24周。结果:中药组治后Scr下降,eGFR升高(P〈0.05~0.01),不良反应少,但尿蛋白却较基线有所增高。西药组治后尿蛋白有减少(P〉0.05),但Scr增高(P〈0.01),其中31例(19.7%)增幅〉30%,8例(5.10%)增幅〉50%,eGFR降低,有27例(17.2%)由CKD3期进展至CKD4期。结论:中药辨证组方对慢性肾脏病具有不依赖于减少尿蛋白的肾保护作用,且安全性好。  相似文献   
107.
108.
    
SARS-CoV-2, the pathogen responsible for the pandemic of coronavirus disease 2019 (COVID-19), has had profound impacts on human health, and its antagonist Paxlovid is a commonly used treatment option [1]. However, treatment selection for immunosuppressed patients, such as liver recipients, remains uncertain due to potential drug interactions and the risk of immunosuppressant dosage adjustment, which can cause liver injury [2]. Therefore, we retrospectively analyzed a case of liver recipient with COVID-19 who experienced deteriorating liver function during anti-COVID-19 therapy.  相似文献   
109.
    

Background and purpose

Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms are typically exclusively linked to primary motor cortex degeneration and the contribution of pre-motor, supplementary motor, cortico-medullary and inter-hemispheric connectivity alterations are less well characterized.

Methods

In a single-centre, prospective, longitudinal neuroimaging study 41 patients with PLS were investigated. Patients underwent standardized neuroimaging, genetic profiling with whole exome sequencing, and comprehensive clinical assessments including upper motor neuron scores, tapping rates, mirror movements, spasticity assessment, cognitive screening and evaluation for pseudobulbar affect. Longitudinal neuroimaging data from 108 healthy controls were used for image interpretation. A standardized imaging protocol was implemented including 3D T1-weighted structural, diffusion tensor imaging and resting-state functional magnetic resonance imaging. Following somatotopic segmentation, cortical thickness analyses, probabilistic tractography, blood oxygenation level dependent signal analyses and brainstem volumetry were conducted to evaluate cortical, brainstem, cortico-medullary and inter-hemispheric connectivity alterations both cross-sectionally and longitudinally.

Results

Our data confirm progressive primary motor cortex degeneration, considerable supplementary motor and pre-motor area involvement, progressive brainstem atrophy, cortico-medullary and inter-hemispheric disconnection, and close associations between clinical upper motor neuron scores and somatotopic connectivity indices in PLS.

Discussion

Primary lateral sclerosis is associated with relentlessly progressive motor connectome degeneration. Clinical disability in PLS is likely to stem from a combination of intra- and inter-hemispheric connectivity decline and primary, pre- and supplementary motor cortex degeneration. Simple ‘bedside’ clinical tools, such as tapping rates, are excellent proxies of the integrity of the relevant fibres of the contralateral corticospinal tract.  相似文献   
110.
    
The European Journal of Health Economics - Colorectal cancer is a global public health issue and imposes a significant economic burden on populations and healthcare systems. This paper...  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号