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931.
Jans T Ball J Preiss M Haberhausen M Warnke A Renner TJ 《Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie》2011,39(5):351-8; quiz 359
Pervasive refusal syndrome (PRS) has been proposed as a new diagnostic entity among child and adolescent psychiatric disorders. It is characterized by a cluster of life-threatening symptoms including refusal of hood intake, decreased or complete lack of mobilization, and lack of communication as well as retreat from normal life activities. Active refusal to accept help as well as neglect of personal care have been core features of PRS in the limited number of cases reported in the last decade. There have, however; been cases with predominantly passive resistance, indicating the possibility that there may be a continuum from active refusal to passive resistance within PRS. Postulating this continuum allows for the integration of "depressive devitalization" -- a refusal syndrome mainly characterized by passive resistance -- into the concept of PRS. Here, three case vignettes of adolescent patients with PRS are presented. The patients' symptomatology can be allocated on this continuum of PRS. PRS and dissociative disorders are compared in greater detail and contrasted within this discussion of differential diagnoses at the poles of such a continuum. PRS is a useful diagnosis for cases involving symptoms of predominating refusal and retreat which cannot satisfactorily be classified by existing diagnostic categories, and which can mostly clearly be separated from dissociative disorder. 相似文献
932.
Taurines R Gerlach M Warnke A Thome J Wewetzer C 《The world journal of biological psychiatry》2011,12(Z1):11-15
In children and adolescents, antidepressants are used in the treatment of depressive symptoms and several other psychiatric conditions. In the treatment of mild and moderate depressive symptoms, non-pharmacological approaches such as psychotherapy play a major role, a severe symptomatology may demand a combination with antidepressants. As first-choice medication for the treatment of juvenile depression, the selective serotonin reuptake inhibitor (SSRI) fluoxetine is recommended, due to its efficacy and approval. As second-choice antidepressants the SSRIs sertraline, escitalopram and citalopram might be used. Other antidepressants - such as tricyclic antidepressants, α(2)-adrenoceptor antagonists, selective noradrenalin reuptake inhibitors (SNRI) - may be alternatively used, but not as first- or second-choice medications. In the case of "off-label" use, patients and parents have to be carefully informed prior to the start of medication, after a thorough risk-benefit analysis. In the following overview we address a general framework, therapeutic strategies and the issues of antidepressant pharmacotherapy for the treatment of unipolar depression in childhood and adolescence. 相似文献
933.
目的 检验特质焦虑量表在农村自杀研究中的信度和效度.方法 应用配对病例对照研究,在山东省疾病监测点上选取3个县(市)自2008年9月1日至2009年8月31日农村自杀死亡病例200例作为病例组,并按照同性别、年龄(±3岁)、当地居住者1:1配比选取正常对照组,用问卷调查和特质焦虑童表进行测评.结果 自杀死亡组和正常对照... 相似文献
934.
935.
936.
937.
Schimmelmann BG Friedel S Dempfle A Warnke A Lesch KP Walitza S Renner TJ Romanos M Herpertz-Dahlmann B Linder M Schäfer H Seitz C Palmason H Freitag C Meyer J Konrad K Hinney A Hebebrand J 《Journal of neural transmission (Vienna, Austria : 1996)》2007,114(4):523-526
Summary Attention deficit/hyperactivity disorder (ADHD) is a highly heritable common neurodevelopmental disorder with onset in childhood.
A coding SNP (rs6265, Val66Met) of the brain-derived neurotrophic factor gene (BDNF) has recently been associated with ADHD. More specifically, paternal over-transmission of the common Val66 allele to affected
children had been observed. We aimed to confirm these findings in a large, sufficiently powered, and well characterized German
ADHD family sample. The Val66Met polymorphism of BDNF was genotyped in 294 families comprising one or more affected sibs (468 children). Contrary to previous reports, we did not
observe over-transmission of the common Val66 allele, from either parent to affected children. We did not find support for
an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in our sample.
First two authors contributed equally. 相似文献
938.
Heiser P Dempfle A Friedel S Konrad K Hinney A Kiefl H Walitza S Bettecken T Saar K Linder M Warnke A Herpertz-Dahlmann B Schäfer H Remschmidt H Hebebrand J 《Journal of neural transmission (Vienna, Austria : 1996)》2007,114(4):513-521
Summary Alterations in the serotonergic pathway have been implicated in the pathogenesis of attention-deficit/hyperactivity disorder
(ADHD). The aim of this study was to investigate seven genetic variants in three genes (serotonin transporter (5-HTT), serotonin receptor 1B (5-HTR1B) and serotonin receptor 2A (5-HTR2A)), which have previously been shown to be associated with ADHD. The polymorphisms under investigation were the 5-HTTLPR,
the VNTR in intron 2 and the 3′UTR SNP in 5-HTT, the 5-HTR1B variations 861G>C and 102T>C, and the 5-HTR2A variations His452Tyr and 1438G>A. We genotyped these variants in a sample of 102 families with 229 children with ADHD according
to DSM-IV criteria. Among the affected children, 69% fulfilled criteria for the combined type, 27% for the predominantly inattentive
type, and 4% for the predominantly hyperactive-impulsive type. Associations were tested by the pedigree transmission disequilibrium
test (PDT). All investigated polymorphisms in serotonergic candidate genes showed no association to ADHD in our sample. Earlier
studies of these polymorphisms had also shown inconsistent results, with some studies reporting significant associations and
others demonstrating no association. This discordance between studies may reflect variation in patient ascertainment criteria,
genetic heterogeneity, too low statistical power for the expected effects or false positive results in the initial reports.
We cannot rule out the possibility that other variations in the investigated genes contribute to the etiology of ADHD. 相似文献
939.
Walitza S Zellmann H Irblich B Lange KW Tucha O Hemminger U Wucherer K Rost V Reinecker H Wewetzer C Warnke A 《Journal of neural transmission (Vienna, Austria : 1996)》2008,115(2):187-190
Summary. In the present study, we have investigated the influence of comorbid attention deficit hyperactivity disorder (ADHD) on early
onset obsessive compulsive disorder (OCD). For that purpose, we compared 20 patients with “OCD with ADHD” and 20 randomly
selected patients with “OCD without ADHD”. “OCD with ADHD” patients tended to show an earlier age of OCD onset, a higher severity
of symptoms and a higher persistence rate than OCD patients without ADHD. Both groups appear to develop different patterns
of comorbid disorders.
The first two authors have equally contributed to the study.
Correspondence: Susanne Walitza, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg,
Füchsleinstr. 15, 97080 Würzburg, Germany 相似文献
940.