Assessment of posture and motion by multichannel piezoresistive accelerometer recordings

Modern assessment of posture and motion involves the use of wide bandwidth piezoresistive accelerometers. The direct current (DC) component allows for assessment of slow motion and change in position referring to the gravitational axis; the alternating current (AC) component, calibrated in g, represents acceleration along the sensitive axis of the device. A method study was designed to evaluate the division in DC and AC components, reliabilities, discrimination between conditions, and detection of types of physical activities. Recordings were made in 26 student participants for eight conditions: sitting, standing, lying supine, sitting and typing on a PC keyboard, walking, climbing stairs, walking downstairs, and cycling. This procedure was repeated in reversed order. A classification of physical activities according to the eight conditions (first trial) and based on four parameters, that is DC components trunk, thigh, and lower leg and AC component trunk, was correct in almost 100% of patterns, when applied to the second trial.     

Peptides related to the active fragment of “proline rich polypeptide”, an immunoregulatory protein of the ovine colostrums

The preferred solution conformation of the PRP-hexapeptide (Tyr-Val-Pro-Leu-Phe-Pro) and of some of its structural analogues was investigated by NMR- spectroscopy, spectrofluorimetry and computer simulation technic. It was found that the preferred conformation is characterized by cis′-conformation of Pro³ and the γ-turn on the Leu⁴-residue: for Val² and Phe⁵ a β-structure seems to be privileged. In such a conformation Val² and Leu⁴ residues occupy exactly the same positions in space as residues i and i+ 3 in an α-helix. It suggests that the PRP-hexapeptide can interact with receptor protein inducing or stabilizing its helical conformation by “knobs into holes” packing.     

Effects of PRES baroreceptor stimulation on thermal and mechanical pain threshold in borderline hypertensives and normotensives

Prior studies have noted a pain relieving effect of baroreceptor stimulation and of higher tonic blood pressure in animals and humans. The present study used a new technique for the controlled, noninvasive stimulation of human carotid baroreceptors (PRES). PRES baroreceptor manipulation was delivered to both normotensive subjects (n= 11) and medication-free labile hypertensive subjects (n= 10) during both thermal and mechanical pain. Consistent with prior research, hypertensives had a higher threshold for thermal pain than did normotensives. PRES baroreceptor manipulation had no significant effect on thermal pain threshold for either group. For the mechanical pain model, the opposite results were obtained; group pain threshold did not differ, but there was a significant PRES baroreceptor stimulation effect of increasing pain threshold for both groups. Results are discussed in terms of specific features of the stimuli, dampening of pain in hypertensives, and adaptation to pain.     

Mobilization of CD34-positive tumour cells in a patient with testicular mixed germ cell tumour

Summary. Tumour cells from a patient with recurrent testicular germ cell cancer and bone marrow infiltration were found to express CD33 and CD34 in the absence of other haemopoiesis-associated antigens. After myelosup-pression and treatment with G-CSF for stem cell mobilization, CD34-positive tumour cells were detected in the peripheral blood in addition to normal haemopoietic progenitor cells. The tumour cells were decreased in the leukapheresis product. Retrospectively, the appearance of tumour cells in the peripheral blood after stem cell mobilization was the first indication of impending relapse.     

Dithranol (anthralin) versus triacetoxyanthracene

In two in vitro models for evaluating antipsoriatic activity, dithranol (anthralin) and triacetoxyan-thracene were compared. Both compounds exhibited an about equal effect on oxygen consumption of surviving human skin. Dithranol, however, exerted a stronger inhibiting effect on gIucose-6-phos-phate dehydrogenase (G-6-PDH) activity of human skin homogenates.