Nitrofuranyl Methyl Piperazines as New Anti-TB Agents: Identification,Validation, Medicinal Chemistry,and PK Studies

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An unusual tracheal foreign body — a case report

Foreign bodies in the laryngopharynx can occur without discrimination of age or sex. Their occurrence is influenced by mode of living, customs, habits and environment. T.M. Paramciwaran(1977) reported 56 cases of foreign bodies of tracheobronchial tree in the span of 5 years. A.S.A. Abdel-Salam and Alan G. Gibb (1980) mentioned that the vast majority of cases occur in young children. They have reported that undiagnosed foreign bodies cause mechanical effects, chemical reactions and may present as chronic pulmonary infection, allergic asthma, bronchiectasis, lung collapse or lung abscess. They present as emergencies and require skilful management.     

Ethnomedicinal plants used by the villagers of district Udhampur,J&K,India

Plants are an integral part of life in many indigenous communities. Besides, being the source of food, fodder, fuel, etc., the use of plants as herbal medicines in curing several ailments goes parallel to the human civilization. Ethnopharmacology involves the investigation of the plants used by the traditional communities and further understand the pharmacological basis of these culturally important medicinal plants. Present study was conducted to enlist the medicinal plants used by the local inhabitants of Udhampur district of Jammu and Kashmir, India.     

Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

Surgical removal of impacted mandibular third molar (SRIMTM) is the most common procedure performed in oral and maxillofacial surgery. In the literature, many complications associated with lower third molar removal are described such as pain, swelling, trismus, infection, inflammation, and nerve damage. Antibiotics are routinely used either pre-operatively or post-operatively to reduce the chances of surgical site infection (SSI). However routine use of antibiotics for SRIMTM is still controversial. For antibiotics to be effective in reducing post-operative infective complications, the time of administration is very important. Adequate serum concentration of antibiotic must be achieved prior to the procedure. In a developing country like India, antibiotics are routinely prescribed post-operatively. The current study is designed to evaluate the efficacy of post-operative prophylactic antibiotic in SRIMTM.     

Treatment with extracts of Momordica charantia and Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats

Insulin resistance has been implicated as a major contributor to the development of hyperglycemia in NIIDM patients. Herbal extracts of Momordica charantia (MC) and Eugenia jambolana (EJ) have been shown to reduce hyperglycemia in diabetic animal models and human patients. However, no work has been done so far to assess their effect on insulin resistance. This study was undertaken to study the effects of different doses (100,200 and 400 mg per day) of alcoholic and aqueous extracts of MC and EJ on the metabolic parameters (body weight and serum glucose, insulin and triglycerides levels) of fructose fed rats. Fructose feeding for 15 days increased serum glucose and insulin levels markedly and triglycerides levels marginally vs. control (75.46+/-2.41 vs. 55.59+/-2.89 mg/dl, 6.26+/-1.27 vs. 15.04+/-2.43 mg/dl and 50.93+/-3.30 vs.41.1+/-3.33 mg/dl, respectively). Treatment with 400 mg per day of aqueous extracts of MC and EJ for 15 days substantially prevented hyperglycemia and hyperinsulinemia induced by a diet high in fructose (63.52+/-2.9 and 66.46+/-2.2 vs. 75.46+/-2.4, respectively).