全文获取类型
收费全文 | 251篇 |
免费 | 18篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 19篇 |
妇产科学 | 5篇 |
基础医学 | 29篇 |
口腔科学 | 17篇 |
临床医学 | 17篇 |
内科学 | 46篇 |
皮肤病学 | 11篇 |
神经病学 | 9篇 |
特种医学 | 1篇 |
外科学 | 56篇 |
综合类 | 3篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 17篇 |
中国医学 | 6篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 2篇 |
2022年 | 10篇 |
2021年 | 15篇 |
2020年 | 13篇 |
2019年 | 7篇 |
2018年 | 15篇 |
2017年 | 11篇 |
2016年 | 14篇 |
2015年 | 11篇 |
2014年 | 26篇 |
2013年 | 7篇 |
2012年 | 23篇 |
2011年 | 20篇 |
2010年 | 10篇 |
2009年 | 9篇 |
2008年 | 12篇 |
2007年 | 12篇 |
2006年 | 11篇 |
2005年 | 6篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2002年 | 4篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1996年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 1篇 |
排序方式: 共有270条查询结果,搜索用时 31 毫秒
121.
Anshul Rai Aakash Arora Vikrant Bhradwaj 《Journal of maxillofacial and oral surgery》2015,14(2):472-473
There are different treatment modalities mentioned in the literature for achieving intermaxillary fixation (IMF). Arch bars are time consuming, can cause damage to the periodontium, maintenance of oral hygiene is poor. Eyelets are not suitable for dentitions that carry extensive crown and bridge work. IMF screw causes root damage. To avoid all these complications we recommended the use of single miniplate for achieving IMF. 相似文献
122.
123.
B. Mohan Reddy Vikal Tripathy Vikrant Kumar Nirmala Alla 《American journal of human biology》2010,22(3):410-417
For historical reasons, the Indian subcontinent is endowed with enormous ethnic, cultural, and genetic heterogeneity of its people. In the process of understanding the dynamics and sociocultural complexity of Indian society, anthropologists have come up with a number of hypotheses involving certain social/cultural processes that may modulate evolutionary processes. In this article, we outline some of those hypotheses and present molecular genetic evidences, both published and unpublished, to demonstrate the effects of those social/cultural processes. Am. J. Hum. Biol. 2010. © 2009 Wiley‐Liss, Inc. 相似文献
124.
Kasat V 《Contemporary clinical dentistry》2011,2(3):245-248
Franceschetti syndrome is an autosomal dominant disorder of craniofacial development with variable expressivity. It is commonly known as Treacher Collins syndrome (TCS). It is named after E. Treacher Collins who described the essential components of the condition. It affects both genders equally. This article reports a case of TCS in an 18-year-old female. 相似文献
125.
The impaction of permanent teeth is not uncommon, but few permanent teeth are rarely impacted like mandibular first and second molars. Though third molars are commonly impacted, inversely impacted mandibular third molars are very rare. Here, we report three unusual cases of impacted mandibular molars accidentally diagnosed on conventional radiographs. 相似文献
126.
Hillmer AM Yao F Inaki K Lee WH Ariyaratne PN Teo AS Woo XY Zhang Z Zhao H Ukil L Chen JP Zhu F So JB Salto-Tellez M Poh WT Zawack KF Nagarajan N Gao S Li G Kumar V Lim HP Sia YY Chan CS Leong ST Neo SC Choi PS Thoreau H Tan PB Shahab A Ruan X Bergh J Hall P Cacheux-Rataboul V Wei CL Yeoh KG Sung WK Bourque G Liu ET Ruan Y 《Genome research》2011,21(5):665-675
Somatic genome rearrangements are thought to play important roles in cancer development. We optimized a long-span paired-end-tag (PET) sequencing approach using 10-Kb genomic DNA inserts to study human genome structural variations (SVs). The use of a 10-Kb insert size allows the identification of breakpoints within repetitive or homology-containing regions of a few kilobases in size and results in a higher physical coverage compared with small insert libraries with the same sequencing effort. We have applied this approach to comprehensively characterize the SVs of 15 cancer and two noncancer genomes and used a filtering approach to strongly enrich for somatic SVs in the cancer genomes. Our analyses revealed that most inversions, deletions, and insertions are germ-line SVs, whereas tandem duplications, unpaired inversions, interchromosomal translocations, and complex rearrangements are over-represented among somatic rearrangements in cancer genomes. We demonstrate that the quantitative and connective nature of DNA-PET data is precise in delineating the genealogy of complex rearrangement events, we observe signatures that are compatible with breakage-fusion-bridge cycles, and we discover that large duplications are among the initial rearrangements that trigger genome instability for extensive amplification in epithelial cancers. 相似文献
127.
Analysis of pediatric tetanus cases was carried out to study the predictors of mortality and role of tetanus immunoglobulin (TIG). Shorter incubation period, onset time and autonomic dysfunction were significantly associated with mortality and may be used to stratify patients requiring intensive care. TIG may not have independent role in decreasing mortality in sick patients. 相似文献
128.
Mittal V Muralee S Williamson D McEnerney N Thomas J Cash M Tampi RR 《American journal of Alzheimer's disease and other dementias》2011,26(2):97-109
Delirium is a common neuropsychiatric syndrome in the elderly characterized by concurrent impairments in cognition and behaviors. The etiologies for delirium are often multifactorial and are due to underlying medical illnesses and/or due to medication effect. The diagnosis of delirium is often missed in elderly patients and this condition may be mislabeled as depression or dementia. Untreated, delirium can have devastating consequences in the elderly with high rates of morbidity and mortality. Available evidence indicates that early detection, reduction of risk factors, and better management of this condition can decrease its morbidity rates. In this review, we discuss the etiology, neurobiology, diagnosis, prevention, and treatments for this potentially lethal condition in the elderly. 相似文献
129.
Kumar A Sinha RA Tiwari M Singh R Koji T Manhas N Rastogi L Pal L Shrivastava A Sahu RP Godbole MM 《Journal of hepatology》2007,46(5):888-898
BACKGROUND/AIMS: The molecular basis of hepatic dysfunction in thyrotoxicosis is not fully understood. Here, we investigated the effect of altered thyroidal status on death receptor pathways including p75 neurotrophin receptor (p75NTR), a member of tumor necrosis factor (TNF) receptor superfamily, in rat liver. METHODS: Hyperthyroidism was induced in Sprague-Dawley rats by daily injections of triiodothyronine in a dose of 12.5 microg/100 g body weight for 10 days. RESULTS: Terminal deoxynucleotide-transferase-mediated dUTP nick end labeling assay and caspase-3 activation data confirmed apoptosis in hyperthyroid rat liver. We observed the elevated levels of death ligands, TNF-alpha, Fas ligand and their cognate receptors, TNF-receptor-1 and Fas, and 8-fold increase in caspase-8 activation in hyperthyroid rat liver (p<0.001). We demonstrated for the first time that hyperthyroidism elevates p75NTR levels and its ligands, pro-nerve growth factor and pro-brain-derived neurotrophic factor, in rat liver. Further we showed that most of the apoptotic cells in hyperthyroid liver express p75NTR. We also demonstrated that triiodothyronine administration to rats causes NF-kappaB activation, but persistent exposure (10 days) to triiodothyronine deactivates NF-kappaB leading to sustained c-Jun N-terminal kinase (JNK) activation. CONCLUSIONS: This study showed that hyperthyroidism-induced apoptosis in rat liver involves the activation of death receptor-mediated pathways, including p75NTR. 相似文献
130.
BACKGROUND/AIMS: Long standing calculus disease has been observed to be a risk factor for gallbladder carcinoma. However it is possible that calculi may be incriminated by some means other than just chronic irritation. Calculi may induce an element of stasis, promoting chronic infection leading to increased turnover of primary bile acids to secondary bile acids, which are known tumor promoters and initiators. This study aimed to find the prevalence of biliary microflora in gallbladder carcinoma and association of gallbladder carcinoma with chronic bacterial infection and bile acid profile. METHODOLOGY: Bile culture was done in 390 patients divided into 3 groups--gallbladder carcinoma 65 (17%), cholelithiasis 125 (32%) and control group 200 (51%). Serum samples were analyzed for presence of Vi antibody for chronic typhoid carrier state and bile acid analysis was done in 10 patients in each group. RESULTS: 116 (30%) patients had culture positive bile. Significantly higher number of patients with gallbladder carcinoma 40 (65%) had culture positive bile as compared to cholelithiasis 52 (42%) and control 24 (12%). Vi Antibodies suggestive of chronic typhoid carrier state were found to be significantly higher in the gallbladder carcinoma group 20 (31%) as compared to controls 22 (11%) (OR 3.596, p < 0.05) however, the difference was statistically insignificant in the cholelithiasis group 12 (11%) (OR 0.859, p > 0.05). There was a 6.84 times higher risk of developing gallbladder carcinoma in culture positive cholelithiasis patients and 5.14 times if both Vi antibody and cultures were positive. Bile analysis showed primary bile acids cholic acid and chenodeoxycholic acid to be lower while secondary bile acids deoxycholic acid and lithocholic acid to be more in the gallbladder carcinoma group (7.268 mg/mL, 9.183 mg/ mL, 14.468 mg/mL, 3.312 mg/mL respectively) than cholelithiasis (17.50 mg/mL, 13.80 mg/mL, 6.07 mg/ mL, 2.05 mg/mL) and control group (19.85 mg/mL, 16.53 mg/mL, 2.71 mg/mL, 1.128 mg/mL respectively). The difference was statistically significant. CONCLUSIONS: Chronic bacterial infection of bile leading to production of carcinogenic precursors might be one of the etiological factors in the pathogenesis of gallbladder carcinoma and hence a target for its prevention. 相似文献