Cannabis Induced Periodic Catatonia: A Case Report

Catatonia is a syndrome of specific motor abnormalities closely associated with disorders in mood, affect, thought and cognition. The principal signs of the disorder are mutism, immobility, negativism, posturing, stereotypy and echo phenomena. Catatonia is commonly seen in various psychiatric disorders, neurological disorders and certain medical conditions. It has also been reported in individuals with substance withdrawal. But we are presenting the case of a patient with cannabis dependence, who presented with symptoms of catatonia preceded by an increase in the amount of cannabis intake and resolution of the catatonia when he abstained from the substance. Literature review did not show any case revealing association between cannabis to catatonia.     

Optimizing atrioventricular and interventricular intervals following cardiac resynchronization therapy

The number of cardiac resynchronization therapy (CRT) device implantations has been increasing exponentially, with the implant rate doubling over the past few years. While the majority of CRT recipients enjoy symptomatic relief, approximately 30% of individuals reap no benefit and only a minority are rendered completely symptom free. In response, many clinicians engage in the theoretically advantageous process of postimplantation optimization of atrial and ventricular stimulation by altering atrioventricular and interventricular pacing intervals. However, the rationale for routine CRT optimization and the methods of doing so have been the subjects of recent debate. Here, we present an overview of the background, techniques and evidence for CRT optimization.     

Fusarium skin infection: a case report

A 65-year-old man presented with an irregular ulcer with a black eschar on his forehead associated with severe headache. A subcutaneous nodule with a necrotic center was present on the left knee. The diagnosis of Fusarium infection was made and confirmed by biopsy and culture. The patient had a history of bronchial asthma for which he was on inhalational steroids for 5 years. It is unclear if this treatment was related to the disseminated Fusarium infection. The patient received oral itraconazole for 3 months with good improvement but met with an unexpected sudden death.     

Changing Spectrum of Retinopathy of Prematurity (ROP) and Variations Among Siblings of Multiple Gestation

Objective  

To assess the changing spectrum of ROP, and to compare the siblings of multiple gestations with regard to incidence and severity of ROP.     

Study of Family Clustering and <Emphasis Type="Italic">PNPLA3</Emphasis> Gene Polymorphism in Pediatric Non Alcoholic Fatty Liver Disease

Objectives

To find association of pediatric NAFLD with metabolic risk factors, and Patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene polymorphism.

Design

Cross-sectional study

Setting

Pediatric Hepatology unit of a tertiary care hospital

Participants

Overweight/obese children (<18 years) with (69 patients) or without (30 patients) NAFLD (ultrasonography based), and their parents.

Intervention

Metabolic screening, PNPLA3 gene polymorphism, and transient elastography

Outcome measure

Association of pediatric NAFLD with parental metabolic risk factors and PNPLA3 gene polymorphism.

Results

In the NAFLD group, there was high parental incidence of metabolic diseases, fatty liver (80%) and low high-density lipoproteins levels (84%). Family history of NAFLD (in any parent), higher alanine aminotransferase levels and higher total cholesterol levels in the child independently predicted possibility of NAFLD, but similar results could not be replicated for PNPLA3 gene polymorphism. Controlled attenuation parameter measurement (by transient elastography) had high sensitivity and specificity to diagnose steatosis.

Conclusion

There is high familial incidence of metabolic diseases in children with NAFLD. Controlled attenuation parameter can be useful as a non-invasive modality to screen fatty liver in children.

     

Unusual formation of keloids after each episode of recurrent herpes zoster in an HIV positive patient

Herpes Zoster (HZ) lesions are well known to heal with keloids. As immunity plays an important role in the development of abnormal scars and keloids, the latter is unusual in HIV where immunity is low. We report a rare case of recurrent HZ in an HIV-positive male where the lesions have healed with formation of keloids in both episodes. Within 50 days of last episode, he had an attack of herpes progenitalis.     

HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study

Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women insouthwestern China. Methods: Cervical cytology, HPV detection by Hybrid Capture-2™ assay, and diagnosticcolposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyzeassociations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinicaland laboratory parameters. Results: Colposcopic-histopathologically proven CIN2+ lesions were present in7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes.HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than womenwith 相似文献