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101.
Shankar EM Kumarasamy N Vignesh R Balakrishnan P Solomon SS Murugavel KG Saravanan S Velu V Farooq SM Hayath K Muthu S Solomon S Rao UA 《Japanese journal of infectious diseases》2007,60(6):337-341
The prevalence of Mycoplasma pneumoniae among HIV-positive patients with community-acquired pneumonia (CAP) remains unclear. We investigated 300 HIV-positive adults (200 with CAP and 100 with no respiratory illness) and 75 HIV-negative adults with CAP for the prevalence of respiratory pathogens using culture and serology. A growth inhibition test was employed to confirm the isolates of M. pneumoniae using species-specific typing sera. The prevalence of M. pneumoniae in HIV-positive subjects was 17% by induced sputum and 11.3% by throat swab culture. The seroprevalence of anti-M. pneumoniae IgM was 11.7% by ELISA and 14.3% by the gelatin microparticle agglutination test. The prevalence of M. pneumoniae among HIV-negative cases was relatively low. Streptococcus pneumoniae was predominant (28%) among subjects with lower respiratory disease, whereas Staphylococcus aureus (15%) was common among upper respiratory symptomatic cases. Rales (P=0.001), pharyngeal erythema (P=0.02), cervical adenopathy (P=0.004), skin rash (P=0.001), and crepitations (P=0.001) were each significantly related to M. pneumoniae positivity. Statistical significance was observed in relation to total lymphocyte count (P=0.02) and erythrocyte sedimentation rate (P=0.04), as well as M. pneumoniae positivity. This study shows that the prevalence of M. pneumoniae in HIV-positive subjects is comparatively higher than in HIV-negative subjects with pulmonary symptoms, and concords with previous pilot studies carried out in Chennai, South India. 相似文献
102.
Devinder K.A. Singh Bala S. Rajaratnam Vijayakumar Palaniswamy Hannah Pearson Vimal P. Raman Pei Sien Bong 《Maturitas》2012
Objective
The objective of this study was to quantify the effectiveness of virtual reality balance games (VRBG) to decrease risk and fear of falls among women.Methods
Thirty six community dwelling women aged 56 and above were randomly divided into experimental (exercises using VRBG focus on improving balance) and control (conventional balance exercises) groups. Both groups attended a twice 6 weekly exercise session for an hour. Risk and fear of falls were measured with Physiological Profile Approach (PPA) and Activity Specific Balance Scale (ABC-6). Pre and post intervention differences between the groups were examined using two way repeated measures ANOVA.Results
Both VRBG and conventional balance exercise groups had significant decrease in PPA (p < 0.001) and ABC-6 (p < 0.01) after the interventions. However, no significant effects were demonstrated between the groups in PPA (p = 0.18) and ABC-6 (p = 0.25) post intervention. Time and group interaction effect were not significant for PPA (p = 0.18) and ABC-6 (p = 0.45).Conclusions
Practising VRBG can increase balance confidence and decrease risk of falls among community dwelling women. 相似文献103.
Vijayakumar Raju Sundar Ramanathan Raman Manjeri Lakshmanan Natarajan Subramanian 《Indian Journal of Thoracic and Cardiovascular Surgery》2010,26(2):167-169
Secondary involvement of the heart and pericardium by systemic lymphoma is well documented. Primary Cardiac lymphomas (PCL)
are extremely rare. Incidence of PCL is increasing in immunocompromised patients. However PCL in immunocompetent is much rarer.
We report such a case of PCL in an immunocompetent elderly female masquerading as right atrial myxoma causing complete heart
block which was surgically debulked successfully. Her rhythm resumed to Sinus rhythm following surgical debulking. Immunohistochemistry
of the excised tumour revealed Diffuse Large B cell lymphoma. With combination chemotherapy, she is symptom free on six months
follow up. 相似文献
104.
105.
106.
T D Pinkney S Raman B Piramanayagam A P Corder 《European journal of surgical oncology》2007,33(5):551-555
AIM: To describe results from a structured clinic pathway designed to minimise inaccuracies and diagnostic delays in the diagnosis of breast cancer. METHODS: Patients referred to our breast clinic undergo clinical, imaging and biopsy assessment according to a standard protocol. Over 4 years, patients who were discharged with a benign diagnosis and later found to have breast cancer were reviewed. RESULTS: A total of 4366 new referrals were seen in the symptomatic breast clinic and 571 (13%) new cancers were diagnosed. Fourteen of the new cancer patients had been seen in the clinic previously (range 7-48 months) and discharged with a benign diagnosis. None of these tumours appeared to result from misdiagnosis of a lesion previously assessed to be benign. The rate of development of cancer in the cohort discharged with a benign diagnosis was closely similar to that in the normal United Kingdom population. CONCLUSIONS: A structured breast clinic pathway can produce a rate of diagnostic accuracy closely approaching 100%. 相似文献
107.
Babak Behnam Azad Raman Chirakal Gary J. Schrobilgen 《Journal of labelled compounds & radiopharmaceuticals》2007,50(14):1236-1242
Previous work from this laboratory has shown that the direct fluorination of 3, 4‐dihydroxy‐phenyl‐L ‐alanine (L ‐DOPA) in anhydrous HF (aHF) or BF3/HF with F2 is an efficient method for the synthesis of 6‐fluoro‐L ‐DOPA. Since then, 18F‐labeled 6‐fluoro‐L ‐DOPA ([18F]6‐fluoro‐L ‐DOPA) has been used to study presynaptic dopaminergic function in the human brain and to monitor gastrointestinal carcinoid tumors. This work demonstrates that the reactivity and selectivity of F2 toward L ‐DOPA in CF3SO3H is comparable with that in aHF. This new synthetic procedure has led to the production of [18F]fluoro‐L ‐DOPA and [18F]fluoro‐D‐DOPA isomers in 17±2% radiochemical yields (decay corrected with respect to [18F]F2). The 2‐ and 6‐FDOPA isomers were separated by HPLC and subsequently characterized by 19F NMR spectroscopy. The corresponding [18F]‐FDOPA enantiomers have been obtained in clinically useful quantities by a synthetic approach that avoids the use of aHF. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
108.
Raman K. Verma Monika Aggarwal Manisha Bansal Inder Preet Kaur 《Medicinal chemistry research》2007,15(9):483-491
An “intellectual connection” approach to design a facile and new synthesis of suitably substituted 2-aminoimidazole-based
precursors of expected antiasthmatic agents through a benzidine type of rearrangement of 2-phenylazoimidazole and subsequent
coupling of the product thus obtained with alkylisothiocyanates involving a degenerative operation, thereby improving the
time frame of the overall synthetic sequence, is reported. The alkylisothiocyanates required in this synthetic sequence are
prepared using a best combination of reported methods. The compounds reported here can be used to produce derivatives of other
biological agents. 相似文献
109.
S.P. Rachagan MRCOG FACS V. Sivanesaratnam FRCOG FICS FACS FRCOG FICS FACS K.P. Kok MRCOG FICS FACS S. Raman MRCOG FICS FACS 《The Australian & New Zealand journal of obstetrics & gynaecology》1988,28(1):29-32
Over a 17-year period, 15 patients with acute puerperal inversion of the uterus were managed at the University Hospital, Kuala Lumpur, an incidence of 1 in 4,836 deliveries. Injudicious traction on the umbilical cord before the uterus was well contracted, was probably the most important causative factor. Haemorrhage was more severe when removal of the placenta was done prior to correction of the inversion. Either the hydrostatic method or manual replacement were used but more often a combination of both techniques was found necessary. With careful management of the third stage of labour, this complication can be avoided. 相似文献
110.
Sebhat IK Martin WJ Ye Z Barakat K Mosley RT Johnston DB Bakshi R Palucki B Weinberg DH MacNeil T Kalyani RN Tang R Stearns RA Miller RR Tamvakopoulos C Strack AM McGowan E Cashen DE Drisko JE Hom GJ Howard AD MacIntyre DE van der Ploeg LH Patchett AA Nargund RP 《Journal of medicinal chemistry》2002,45(21):4589-4593
Synthetic and natural peptides that act as nonselective melanocortin receptor agonists have been found to be anorexigenic and to stimulate erectile activity. We report the design and development of 1, a potent, selective (1184-fold vs MC3R, 350-fold vs MC5R), small-molecule agonist of the MC4 receptor. Pharmacological testing confirms the food intake lowering effects of MC4R agonism and suggests another role for the receptor in the stimulation of erectile activity. 相似文献