全文获取类型
收费全文 | 1073篇 |
免费 | 87篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 67篇 |
妇产科学 | 45篇 |
基础医学 | 125篇 |
口腔科学 | 29篇 |
临床医学 | 97篇 |
内科学 | 341篇 |
皮肤病学 | 39篇 |
神经病学 | 99篇 |
特种医学 | 27篇 |
外科学 | 76篇 |
综合类 | 3篇 |
预防医学 | 56篇 |
眼科学 | 28篇 |
药学 | 42篇 |
中国医学 | 2篇 |
肿瘤学 | 83篇 |
出版年
2024年 | 1篇 |
2023年 | 18篇 |
2022年 | 34篇 |
2021年 | 50篇 |
2020年 | 33篇 |
2019年 | 48篇 |
2018年 | 58篇 |
2017年 | 45篇 |
2016年 | 30篇 |
2015年 | 35篇 |
2014年 | 45篇 |
2013年 | 85篇 |
2012年 | 107篇 |
2011年 | 109篇 |
2010年 | 61篇 |
2009年 | 53篇 |
2008年 | 73篇 |
2007年 | 55篇 |
2006年 | 67篇 |
2005年 | 44篇 |
2004年 | 49篇 |
2003年 | 23篇 |
2002年 | 16篇 |
2001年 | 6篇 |
2000年 | 3篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 6篇 |
1994年 | 2篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有1168条查询结果,搜索用时 31 毫秒
31.
Anargyros Kouris MD MSc PhD Christos Christodoulou MD PhD Vasiliki Efstathiou MSc Iakovoula Chatzimichail MSc Nikoletta Zakopoulou MD Eftychia Zouridaki MD PhD 《Wound repair and regeneration》2015,23(5):778-780
Leg ulcers have been shown to have a significant impact on a patient's quality of life (QoL). Little is known, however, about the secondary impact of the disease on the QoL of the relatives and partners of patients with leg ulcers. The aim of this study was to explore the impact of chronic leg ulcers on the lives of both patients and their family members. Two hundred sixteen patients with leg ulcers and their family members were recruited. All patients entered were evaluated for QoL using the Dermatology Life Quality Index (DLQI) scale, and family members were similarly evaluated using the Family Dermatology Life Quality Index (FDLQI).The study included 56 female and 52 male patients, and 50 female and 58 male family members. The FDLQI score for the latter group was 14.37 ± 2.46 with over 96% of family members reporting a large effect on their QoL due to their relative's disease. The DLQI score in patients with leg ulcers was 13.18 ± 2.88. A significant positive and high correlation between DLQI and FDLQI scores (r = 0.71, p < 0.001) was documented, while DLQI contributed significantly to the prediction of FDLQI (standardized β = 0.71, p < 0.001). Our study results indicate that the QoL of the family was also affected by the patient's condition of chronic leg ulcers and clearly associated with that of the patients. 相似文献
32.
Ilias Karaiskos Lena E. Friberg Konstantinos Pontikis Konstantinos Ioannidis Vasiliki Tsagkari Lamprini Galani Eirini Kostakou Fotini Baziaka Charalambos Paskalis Antonia Koutsoukou Helen Giamarellou 《Antimicrobial agents and chemotherapy》2015,59(12):7240-7248
Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as the last-resort treatment in critically ill patients. Recent studies focusing on the optimal dosing strategy of colistin have demonstrated the necessity of a loading dose at treatment initiation (D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430–3436, 2009, http://dx.doi.org/10.1128/AAC.01361-08; A. F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, E. Papadomichelakis, A. Antoniadou, H. Giamarellou, A. Armaganidis, O. Cars, and L. E. Friberg, Antimicrob Agents Chemother 56:4241– 4249, 2012, http://dx.doi.org/10.1128/AAC.06426-11; S. M. Garonzik, J. Li, V. Thamlikitkul, D. L. Paterson, S. Shoham, J. Jacob, F. P. Silveira, A. Forrest, and R. L. Nation, Antimicrob Agents Chemother 55:3284–3294, 2011, http://dx.doi.org/10.1128/AAC.01733-10). In 19 critically ill patients with suspected or microbiologically documented infections caused by XDR Gram-negative strains, a loading dose of 9 MU colistin methanesulfonate (CMS) (∼270 mg colistin base activity) was administered with a maintenance dose of 4.5 MU every 12 h, commenced after 24 h. Patients on renal replacement were excluded. CMS infusion was given over 30 min or 1 h. Repeated blood sampling was performed after the loading dose and after the 5th or 6th dose. Colistin concentrations and measured CMS, determined after hydrolization to colistin and including the partially sulfomethylated derivatives, were determined with a liquid chromatography-tandem mass spectrometry assay. Population pharmacokinetic analysis was conducted in NONMEM with the new data combined with data from previous studies. Measured colistimethate concentrations were described by 4 compartments for distribution and removal of sulfomethyl groups, while colistin disposition followed a 1-compartment model. The average observed maximum colistin A plus B concentration was 2.65 mg/liter after the loading dose (maximum time was 8 h). A significantly higher availability of the measured A and B forms of colistimethate and colistin explained the higher-than-expected concentrations in the present study compared to those in previous studies. Creatinine clearance was a time-varying covariate of colistimethate clearance. The incidence of acute renal injury was 20%. 相似文献
33.
Stamatis Adamopoulos Jean‐Paul Schmid Paul Dendale Daniel Poerschke Dominique Hansen Athanasios Dritsas Alexandros Kouloubinis Toon Alders Aggeliki Gkouziouta Ilse Reyckers Vasiliki Vartela Nikos Plessas Costas Doulaptsis Hugo Saner Ioannis D. Laoutaris 《European journal of heart failure》2014,16(5):574-582
34.
Malignant mesothelioma cells secrete natriuretic peptides: Data and diagnostic clinical implications
35.
36.
Vasiliki Pogka Afroditi Moutousi Athanasios Kossyvakis Antonios Kalliaropoulos Dionyssios N. Sgouras Maria Giannaki Andreas F. Mentis 《Influenza and other respiratory viruses》2014,8(1):107-115
Objectives
The genotypic analysis of human metapneumo-(HMPV) and boca-(HBoV) viruses circulating in Greece and their comparison to reference and other clinical strains.Design
Genetic analysis of representative strains over three consecutive winter seasons of the years 2005–2008.Setting
Representative positive specimens for HMPV and HBoV from paediatric patients of healthcare units and hospitals in Southern Greece with influenza-like illness or other respiratory tract infections.Sample
Seven to ten positive specimens for either HMPV or HBoV from each winter period. In total, 24 specimens positive for HMPV and 26 for HBoV, respectively.Main outcome measures
Sequence diversity of HMPV and HBoV strains by sequencing the complete G and VP1/VP2 genes, respectively.Results
In total, 24 HMPV strains were found to have a 92–100% nucleotide and a 85.9–100% amino acid identity. Phylogenetic analysis based on the number of amino acid differences, revealed circulation of 4 different subclusters belonging to genetic lineage B2. Similarly, analysis of 26 HBoV strains indicated that 22 clustered within genotype St2, 2 into genotype St1 and the remaining 2 formed a third cluster derived from potential recombination between different St1 genotype strains. St2 HBoV genotype was observed throughout the whole observation period whereas St1 only during the second and the third winter period. Higher levels of heterogeneity were observed between HMPV compared to HBoV strains.Conclusions
Phylogenetic analysis revealed circulation of one single lineage (B2) for HMPV viruses and predominance of St2 genotype for HBoV viruses. A possible recombination between St1 genotype strains of HBoV was observed. 相似文献37.
38.
39.
40.
Spyridon Deftereos MD Georgios Giannopoulos Charalambos Kossyvakis Michael Efremidis Vasiliki Panagopoulou Andreas Kaoukis Konstantinos Raisakis Georgios Bouras Christos Angelidis Andreas Theodorakis Metaxia Driva Konstantinos DoudoumisVlasios Pyrgakis MD Christodoulos Stefanadis 《Journal of the American College of Cardiology》2012