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Davide Firinu Vanessa Garcia-Larsen Paolo Emilio Manconi Stefano R. Del Giacco 《Current rheumatology reports》2016,18(6):35
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. Its main features are prominent inflammatory cutaneous and articular manifestations. Treatments with immunosuppressive drugs have been used for the management of SAPHO with variable results. To date, the use of anti-TNF-α agents has proved to be an effective alternative to conventional treatment for unresponsive or refractory SAPHO cases. TNF-α is a pro-inflammatory cytokine and pivotal regulator of other cytokines, including IL-1 β, IL-6, and IL-8, involved in inflammation, acute-phase response induction, and chemotaxis. IL-1 inhibition strategies with anakinra have shown efficacy as first and second lines of treatment. In this review, we will describe the main characteristics of biological drugs currently used for SAPHO syndrome. We also describe some of the promising therapeutic effects of ustekinumab, an antibody against the p40 subunit of IL-12 and IL-23, after failure of multiple drugs including anti-TNF-α and anakinra. We discuss the use and impact of the new anti-IL-1 antagonists involved in the IL-17 blockade, in particular for the most difficult-to-treat SAPHO cases. 相似文献
84.
The purpose is to examine the impact of the Implantable Miniature Telescope procedure on the level of treatment satisfaction and quality of life of individuals with end-stage age-related macular degeneration. Six individuals who had undergone the Implantable Miniature Telescope procedure were recruited. The participants completed two survey instruments about their overall quality of life and level of treatment satisfaction post intervention. In-depth interviews were also conducted to gain a perspective of the participant’s lived experience. A moderately high quality-of-life and treatment satisfaction rating was reported by participants post intervention. Qualitative themes included loss of independence, realistic perspective about the procedure, importance of rehabilitation following the procedure, and high treatment satisfaction despite lack of improvement in visual functioning. Moderately high quality-of-life ratings and treatment satisfaction were reported despite reports of limited improvements in participants’ visual function and ability to utilize the Implantable Miniature Telescope. However, qualitative responses revealed a negative impact on quality of life in relation to their diagnosis of end-stage age-related macular degeneration, but not in direct relation to the Implantable Miniature Telescope procedure. 相似文献
85.
Ida Alzira Gomes Duarte Karen Levy Korkes Vanessa Alice M. Amorim Clarice Kobata Roberta Buense Rosana Lazzarini 《Anais brasileiros de dermatologia》2013,88(2):306-308
Whether parapsoriasis represents an early stage of T-cell cutaneous lymphoma is still
the subject of controversy. We evaluated the efficacy of phototherapy in the
treatment of parapsoriasis and its relation with TCCL. Patients diagnosed with
parapsoriasis and treated with phototherapy PUVA or UVB-NB were selected. Between 1
to 8 years following treatment the evolution of their disease was evaluated. In 62
patients the cure rate was 79.3% and 17.2% showed improvement of the lesions. Only
two patients developed full blown T-cell cutaneous lymphoma. Phototherapy is an
excellent treatment for parapsoriasis, with high cure rates, regardless of the type
of phototherapy employed. Of the 62 patients under study, parapsoriasis showed no
general tendency to progress to T-cell cutaneous lymphoma. 相似文献
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Vanessa Moñivas Palomero Alejandro Durante-Lopez Mario Torres Sanabria Javier Segovia Cubero Jesús González-Mirelis Jorge Vazquez Lopez-Ibor Sara M. Navarro Rico Isabel Krsnik Fernando Dominguez Alejandro Martinez Mingo Francisco J. Hernandez-Perez Gibanel Cavero Susana Mingo Santos 《Journal of the American Society of Echocardiography》2019,32(7):845-853.e1
88.
Sarah Yale MD Nicole Stefanko MD Patrick McCarthy MD MME Vanessa McFadden MD PhD James McCarthy MD 《Pediatric dermatology》2020,37(2):377-378
Dapsone gel is a topical treatment for facial acne in adolescents and adults, and while systemic dapsone therapy is known to be associated with methemoglobinemia, once-daily topical dapsone has been well tolerated with few side effects in large randomized controlled trials. We describe the first reported case of severe methemoglobinemia in a healthy adolescent using daily topical dapsone. Although the medication was prescribed for facial use only, the patient reported topical use over her back and chest as well. This case illustrates the potential for significant systemic dapsone absorption even with daily topical dosing and demonstrates the need for clear anticipatory guidance to prevent the potential morbidity and mortality associated with methemoglobinemia from improper topical dapsone use. 相似文献
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