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31.
Sinisa Cikic Partha K Chandra Jarrod C Harman Ibolya Rutkai Prasad VG Katakam Jessie J Guidry Jeffrey M Gidday David W Busija 《Journal of cerebral blood flow and metabolism》2021,41(2):397
Sex differences in mitochondrial numbers and function are present in large cerebral arteries, but it is unclear whether these differences extend to the microcirculation. We performed an assessment of mitochondria-related proteins in cerebral microvessels (MVs) isolated from young, male and female, Sprague-Dawley rats. MVs composed of arterioles, capillaries, and venules were isolated from the cerebrum and used to perform a 3 versus 3 quantitative, multiplexed proteomics experiment utilizing tandem mass tags (TMT), coupled with liquid chromatography/mass spectrometry (LC/MS). MS data and bioinformatic analyses were performed using Proteome Discoverer version 2.2 and Ingenuity Pathway Analysis. We identified a total of 1969 proteins, of which 1871 were quantified by TMT labels. Sixty-four proteins were expressed significantly (p < 0.05) higher in female samples compared with male samples. Females expressed more mitochondrial proteins involved in energy production, mitochondrial membrane structure, anti-oxidant enzyme proteins, and those involved in fatty acid oxidation. Conversely, males had higher expression levels of mitochondria-destructive proteins. Our findings reveal, for the first time, the full extent of sexual dimorphism in the mitochondrial metabolic protein profiles of MVs, which may contribute to sex-dependent cerebrovascular and neurological pathologies. 相似文献
32.
Mainz J Hammer U Rokahr C Hubler A Zintl F Ballmann M 《Respiration; international review of thoracic diseases》2006,73(5):698-704
Cystic fibrosis (CF) is a recessive genetic disease caused by defects of the cystic fibrosis trans-membrane regulator (CFTR) gene with a median survival of less than 35 years. This work reports on the oldest living German siblings with CF. Besides clinical history, CF genotype and nasal potential difference (NPD) measurement results, the remarkably high exercise activity of the siblings is discussed as a disease-modifying factor. Both male patients have an overall mild pulmonary manifestation. They have suffered from abdominal symptoms since their early childhood, including recurrent pancreatitis and diffuse symptoms leading to partial gastric resection. They were diagnosed as having CF with positive sweat tests at the advanced ages of 45 and 43 years, respectively. Later on genotyping revealed compound heterozygosity for F508del and 2789+5G-->A. Using NPD we demonstrated a CF-typical inhibition of the NPD by the Na channel blocker amiloride, although in both siblings the remaining CFTR function and alternate chloride channel function were detected during superfusion of the nasal epithelium with isoproterenol and ATP. Long-term survival with CF is basically influenced by the CFTR genotype. The patients' genotype was discussed as a mild one with remaining CFTR function. We demonstrated this residual CFTR function in both siblings using NPD. Additionally the siblings' continuous healthy lifestyle and their engagement in a remarkably high level of exercise activities from early childhood to the present possibly have an important effect on the long-term outcome of CF as disease-modifying factors. In this regard this report can encourage CF patients to maintain a high level of physical activity in their daily lives. 相似文献
33.
Bühren K Mainz V Herpertz-Dahlmann B Schäfer K Kahraman-Lanzerath B Lente C Konrad K 《Journal of neural transmission (Vienna, Austria : 1996)》2012,119(9):1047-1057
Deficits in set-shifting abilities have been robustly described in adult patients with anorexia nervosa (AN). These deficits are associated with behavioral traits, such as rigidity and perfectionism, and are independent of starvation. However, little is known about neurocognitive deficits in juvenile patients with AN. The brain circuits that support set shifting are not fully mature in these patients. One possibility is that neuroendocrinological changes, such as elevated cortisol levels, contributing to alterations in cognitive performance in individuals with AN. Set-shifting abilities (Visual Set-Shifting Task), cortisol levels, self-reported perfectionism and obsessive personality traits were assessed in 28 female adolescent patients with AN before (T0) and after (T1) weight rehabilitation and compared with 27 age- and IQ-matched healthy controls (CG). Compared with the CG, AN patients showed increased reaction times (RT) in shift trials (p?0.001) and reduced error rates in both shift and non-shift trials across time points (p?0.05). Across all subjects, perfectionism was associated with increased RTs during shift trials at T1 (r?=?0.35, p?0.05). Subjects with lower cortisol levels showed increased RTs and more errors in non-shift trials (p?0.05). In contrast to the findings in adult patients, adolescent patients with AN did not display a marked deficit in set-shifting abilities. Instead, they demonstrated a perfectionistic cognitive style that was characterized by increased RTs in shift trials but improved accuracy. One could speculate that the shorter duration of illness and the incomplete maturation of the prefrontal cortices contribute to these findings. 相似文献
34.
35.
VG Münster 《MedR Medizinrecht》1999,17(3):146-148
Ohne Zusammenfassung 相似文献
36.
VG Gelsenkirchen 《MedR Medizinrecht》1999,17(9):427-429
Ohne Zusammenfassung 相似文献
37.
VG Karlsruhe 《MedR Medizinrecht》1999,17(7):329-331
Ohne Zusammenfassung 相似文献
38.
39.
Dopfer C Kentouche K Gruhn B Dopfer R Becker S Mentzel HJ Beck JF Mainz JG 《Klinische P?diatrie》2011,223(6):368-369
40.
We present the case of a 44-year-old wrestler suffering from persistent bronchitis and chronic rhinosinusitis which had been refractory to therapy. The patient underwent extensive diagnostic examinations throughout the disease. Recently, at the age of 42 years otorhinological controls led to presentation at a cystic fibrosis (CF) centre where CF with the genotype Fdel508/3849+10 kb C→T was diagnosed despite borderline sweat tests. Atypical CF should be considered in chronic persistent rhinosinusitis even in patients with borderline sweat tests. 相似文献