全文获取类型
收费全文 | 1609篇 |
免费 | 102篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 57篇 |
妇产科学 | 67篇 |
基础医学 | 162篇 |
口腔科学 | 53篇 |
临床医学 | 158篇 |
内科学 | 333篇 |
皮肤病学 | 20篇 |
神经病学 | 54篇 |
特种医学 | 60篇 |
外科学 | 311篇 |
综合类 | 41篇 |
一般理论 | 1篇 |
预防医学 | 91篇 |
眼科学 | 36篇 |
药学 | 123篇 |
中国医学 | 9篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 21篇 |
2022年 | 74篇 |
2021年 | 79篇 |
2020年 | 45篇 |
2019年 | 51篇 |
2018年 | 67篇 |
2017年 | 44篇 |
2016年 | 37篇 |
2015年 | 52篇 |
2014年 | 69篇 |
2013年 | 79篇 |
2012年 | 115篇 |
2011年 | 112篇 |
2010年 | 75篇 |
2009年 | 42篇 |
2008年 | 72篇 |
2007年 | 79篇 |
2006年 | 86篇 |
2005年 | 63篇 |
2004年 | 55篇 |
2003年 | 50篇 |
2002年 | 59篇 |
2001年 | 23篇 |
2000年 | 23篇 |
1999年 | 20篇 |
1998年 | 15篇 |
1997年 | 9篇 |
1996年 | 4篇 |
1995年 | 12篇 |
1994年 | 13篇 |
1993年 | 7篇 |
1992年 | 16篇 |
1991年 | 10篇 |
1990年 | 18篇 |
1989年 | 15篇 |
1988年 | 19篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 10篇 |
1983年 | 8篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1976年 | 3篇 |
1974年 | 3篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1969年 | 4篇 |
1967年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有1719条查询结果,搜索用时 46 毫秒
31.
32.
N. Y. Haboubi S. A. Abdalla S. Amini P. Clark M. Dougal A. Dube P. Schofield 《International journal of colorectal disease》1998,13(2):99-102
To evaluate the significance of micrometastases in relation to survival rate, specimens from 48 colorectal carcinoma patients
were analysed after fat clearance. The number and size of the lymph nodes harbouring metastases and the significance of micrometastases
for patients' survival were assessed. We found that although the majority of metastatic lymph nodes (71.8%) were 5 mm or less
in diameter, their size had no effect on survival. Immunohistochemical staining of lymph nodes revealed that 15 of 25 patients
with Dukes' stage B diagnosed by routine staining had micrometastases, 86% of these lymph nodes being less than 5 mm in diameter.
The survival rate of this subgroup was found to be considerably poorer than that of Dukes' stage B patients with no micrometastases.
None of the three patients with Dukes' stage A carcinoma had micrometastases. Since most of the metastases and micrometastases
occur in lymph nodes of 5 mm and less and can be easily missed by routine examination, we suggest that fat clearance and routine
immunohistochemical analysis of Dukes' stage B improve the prediction of outcome of colorectal cancer patients.
Accepted: 10 February 1998 相似文献
33.
34.
Oral prolecohen (LEK, Yugoslavia) was given in a single dose of 300 mg to 15 patients with extrasystole of various genesis. The drug produced an antiarrhythmic effect in 50% of patients with ventricular extrasystole, but in those with supraventricular extrasystole. Prolecophenum showed a good tolerance. In 20% of the patients the adverse reactions appeared as mild headache, dizziness, dry mouth, malaise in the epigastric region. There is also evidence for efficacy of other antiarrhythmic agents used in this group of patients. 相似文献
35.
Mohamed Labib Salem Abdel-Aziz A. Zidan Randa Ezz El-Din El-Naggar Mohamed Attia Saad Mohamed El-Shanshory Usama Bakry Mona Zidan 《Human immunology》2021,82(1):36-45
BackgroundRelapse remains a critical challenge in children with acute lymphoblastic leukemia (ALL). The emergence of immunoregulatory cells, including myeloid-derived suppressor cells (MDSCs), and T regulatory (Treg) cells, has been considered one potential mechanism of relapse in children with ALL.AimThis study aimed to address the microRNAs (miRNAs) related to MDSCs and Treg cells and to explore their targeted immunoregulatory pathways.MethodsAffymetrix microarray was used for global miRNA profiling in B-ALL pediatric patients before, during, and after induction of chemotherapy. Bioinformatics analysis was performed on MDSCs and Treg cells-related dysregulated miRNAs, and miR-Pathway analysis was performed to explore their targeted immunoregulatory pathways.Results516 miRNAs were dysregulated in ALL patients as compared to the healthy donor. Among them, 13 miRNAs and 8 miRNAs related to MDSCs and Treg cells, respectively, were common in all patients. Besides, 12 miRNAs were shared between MDSCs and Treg cells; 4 of them were common in all patients. Four immune-related pathways; TNF, TGF-β, FoxO, and Hippo were found implicated.ConclusionOur pilot study concluded certain miRNAs related to MDSCs and Treg cells, these miRNAs were linked to immunoregulatory pathways. Our results open avenues for testing those miRNA as molecular biomarkers for the immunosuppressive tumor microenvironment. 相似文献
36.
37.
Enas Reda Abdelaleem Mamdouh Nabil Samy Samar Yehia Desoukey Miaomiao Liu Ronald J. Quinn Usama Ramadan Abdelmohsen 《RSC advances》2020,10(57):34959
Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities. Sponges which belong to the order Dictyoceratida are distinctly classified into 5 families: Dysideidae, Irciniidae, Spongiidae, Thorectidae, and Verticilliitidae. In this review, compounds isolated from Dictyoceratida sponges were discussed with their biological potential within the period 2013 to December 2019. Moreover, analysis of the physicochemical properties of these marine natural products was investigated and the results showed that 78% of the compounds have oral bioavailability potential. This review highlights sponges of the order Dictyoceratida as exciting source for discovery of new drug leads.Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities. 相似文献
38.
Michel D. Crema Andre F. Yamada Ali Guermazi Frank W. Roemer Abdalla Y. Skaf 《Current reviews in musculoskeletal medicine》2015,8(2):154-161
Magnetic resonance imaging (MRI) and ultrasound are the imaging modalities of choice to assess muscle injuries in athletes. Most authors consider MRI as the reference standard for evaluation of muscle injuries, since it superiorly depicts the extent of injuries independently of its temporal evolution, and due to the fact that MRI seems to be more sensitive for the detection of minimal injuries. Furthermore, MRI may potentially allow sports medicine physicians to more accurately estimate recovery times of athletes sustaining muscle injuries in the lower limbs, as well as the risk of re-injury. However, based on data available, the specific utility of imaging (including MRI) regarding its prognostic value remains limited and controversial. Although high-quality imaging is systematically performed in professional athletes and data extracted from it may potentially help to plan and guide management of muscle injuries, clinical (and functional) assessment is still the most valuable tool to guide return to competition decisions. 相似文献
39.
Annie Leprêtre Idrissa Ba Karine Lacombe Maryvonne Maynart Abdalla Toufik Ousseynou Ndiaye Coumba Toure Kane Joël Gozlan Judicaël Tine Ibrahim Ndoye Gilles Raguin Pierre‐Marie Girard 《Journal of the International AIDS Society》2015,18(1)
Objectives
Data on the extent of drug use and associated HIV, hepatitis C and hepatitis B infection in West Africa are lacking. The objectives of ANRS12244 UDSEN study were to estimate the size of the heroin and/or cocaine drug user (DU) population living in the Dakar area (Senegal), and assess the prevalence and risk factors of HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV), including behavioural determinants in this population, in order to set up an integrated prevention and treatment programme for DUs.Design and methods
A capture-recapture method was applied for population size estimation, whereas the respondent-driven sampling (RDS) method was used to recruit a sample of DUs living in the Dakar area and determine HIV, HBV and HCV prevalence. Behavioural data were gathered during face-to-face interviews, and blood samples were collected on dried blood spots for analysis in a central laboratory. Data analysis was performed using the RDS analysis tool, and risk factors were determined by logistic regression. Access to laboratory results was organized for the participants.Results
The size of the DU population in the Dakar area was estimated to reach 1324 (95% confidence interval (95% CI: 1281–1367)). Based on the 506 DUs included in the study, the HIV, HCV and HBV prevalence were 5.2% (95% CI: 3.8–6.3), 23.3% (95% CI: 21.2–25.2) and 7.9% (95% CI: 5.2–11.1), respectively. In people who inject drugs (PWID), prevalence levels increased to 9.4% for HIV and 38.9% for HCV (p=0.001 when compared to those who never injected). Women were more at risk of being HIV infected (prevalence: 13.04% versus 2.97% in males, p=0.001). Being PWID was a risk factor for HCV and HIV infection (odds ratio, OR: 2.7, 95% CI: 1.7–4.3, and OR: 4.3, 95% CI: 1.7–10.7, respectively), whereas older age and female sex were additional risk factors for HIV infection (10% increase per year of age, p=0.03 and OR: 4.9, 95% CI: 1.6–156, respectively). No specific determinant was associated with the risk of HBV infection.Conclusions
High HIV and HCV prevalence were estimated in this population of DUs (including non-injectors) living in the Dakar area, Senegal, whereas HBV prevalence was close to that of the global Senegalese population, reflecting a risk of infection independent of drug use. Women seem to be highly vulnerable and deserve targeted interventions for decreasing exposure to HIV, while behavioural risk factors for HIV and HCV include the use of unsafe injections, reflecting the urgent need for developing harm reduction interventions and access to opioid substitution therapy services. 相似文献40.
We report a case of a 17-year-old female patient, who was operated on for choledocal cyst with Roux-en Y hepatojejunostomy. She was admitted to hospital with recurrent attacks of acute ascending cholangitis due to left intrahepatic duct stones. After a failed attempt at conventional endoscopic retrograde cholangiopancreatography through the anatomical route, she was treated successfully with laparoscopy assisted transjejunal endoscopic retrograde cholangiography.Endoscopic access to the biliary system can be difficult in patients with surgically altered anatomy of the upper gastrointestinal tract (GIT), such as Roux-en-Y reconstruction, because of the changed anatomy. However, endoscopic retrograde cholangiopancreatography (ERCP) is challenging in cases such as our patient;1,2 this is due to the distance needed to be traversed and looping. Our objective in presenting this particular case is to describe and highlight a laparoscopy assisted transjejunal ERCP to permit successful treatment and removal of intrahepatic duct stones in a post Roux-en-Y patient, and to minimize surgical inetervention to reduce unnecessary risks to the patient. 相似文献