全文获取类型
收费全文 | 2285篇 |
免费 | 165篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 97篇 |
妇产科学 | 15篇 |
基础医学 | 320篇 |
口腔科学 | 220篇 |
临床医学 | 226篇 |
内科学 | 362篇 |
皮肤病学 | 24篇 |
神经病学 | 217篇 |
特种医学 | 86篇 |
外科学 | 478篇 |
综合类 | 17篇 |
一般理论 | 3篇 |
预防医学 | 89篇 |
眼科学 | 45篇 |
药学 | 139篇 |
中国医学 | 2篇 |
肿瘤学 | 115篇 |
出版年
2023年 | 18篇 |
2022年 | 15篇 |
2021年 | 24篇 |
2020年 | 27篇 |
2019年 | 30篇 |
2018年 | 42篇 |
2017年 | 36篇 |
2016年 | 48篇 |
2015年 | 46篇 |
2014年 | 73篇 |
2013年 | 108篇 |
2012年 | 146篇 |
2011年 | 152篇 |
2010年 | 93篇 |
2009年 | 116篇 |
2008年 | 170篇 |
2007年 | 164篇 |
2006年 | 151篇 |
2005年 | 151篇 |
2004年 | 148篇 |
2003年 | 137篇 |
2002年 | 125篇 |
2001年 | 21篇 |
2000年 | 19篇 |
1999年 | 24篇 |
1998年 | 25篇 |
1997年 | 24篇 |
1996年 | 21篇 |
1995年 | 23篇 |
1994年 | 16篇 |
1993年 | 16篇 |
1992年 | 17篇 |
1991年 | 23篇 |
1989年 | 18篇 |
1988年 | 18篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 14篇 |
1984年 | 13篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 6篇 |
1979年 | 10篇 |
1978年 | 7篇 |
1976年 | 7篇 |
1975年 | 10篇 |
1974年 | 8篇 |
1973年 | 8篇 |
1969年 | 7篇 |
1967年 | 6篇 |
排序方式: 共有2465条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
Azhar A. Khan Aadithya B. Urs Jeyaseelan Augustine Hanspal Singh 《The Journal of forensic odonto-stomatology》2020,38(3):35
The grinding of a whole tooth specimen has been considered the conventional method to extract genomic deoxyribonucleic acid (DNA) in forensic science. However, we have tried the less destructive reverse root canal filing (RRCF) method without disturbing the morphology of the tooth to achieve competent amplifiable DNA. A total of 27 pairs of bilateral intact extracted teeth from the same subject were used in three different simulated environmental conditions for the respective RRCF and conventional methods: (a) soil burial for six months, (b) incineration at 200º C for four minutes, and (c) immersion in water for two months. Qualitative agarose gel electrophoresis assessment and downstream amplification were performed. The results showed significantly higher mean DNA concentration for the RRCF method in all three environmental conditions (p value = 0.008) in comparison to the conventional method. However, comparable qualitative results were found in both methods for the mean DNA concentration for incinerated (159.49 ng/ml), soil (119.52 ng/ml), and water (108.60 ng/ml) samples. It was concluded that the RRCF method is better quantitively (ng/ml) and comparable in terms of quality with respect to the conventional method, with the added advantage of preservation of the tooth morphology. 相似文献
55.
56.
Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis 总被引:7,自引:0,他引:7 下载免费PDF全文
57.
58.
Jenny Bj?rkqvist Steven de Maat Urs Lewandrowski Antonio Di Gennaro Chris Oschatz Kai Sch?nig Markus M. N?then Christian Drouet Hal Braley Marc W. Nolte Albert Sickmann Con Panousis Coen Maas Thomas Renné 《The Journal of clinical investigation》2015,125(8):3132-3146
Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated with point mutations in the gene encoding the plasma protease factor XII (FXII). Here, we demonstrate that HAEIII-associated mutant FXII, derived either from HAEIII patients or recombinantly produced, is defective in mucin-type Thr309-linked glycosylation. Loss of glycosylation led to increased contact-mediated autoactivation of zymogen FXII, resulting in excessive activation of the bradykinin-forming kallikrein-kinin pathway. In contrast, both FXII-driven coagulation and the ability of C1-esterase inhibitor to bind and inhibit activated FXII were not affected by the mutation. Intravital laser-scanning microscopy revealed that, compared with control animals, both F12–/– mice reconstituted with recombinant mutant forms of FXII and humanized HAEIII mouse models with inducible liver-specific expression of Thr309Lys-mutated FXII exhibited increased contact-driven microvascular leakage. An FXII-neutralizing antibody abolished bradykinin generation in HAEIII patient plasma and blunted edema in HAEIII mice. Together, the results of this study characterize the mechanism of HAEIII and establish FXII inhibition as a potential therapeutic strategy to interfere with excessive vascular leakage in HAEIII and potentially alleviate edema due to other causes. 相似文献
59.
Zingg U Miskovic D Pasternak I Meyer P Hamel CT Metzger U 《International journal of colorectal disease》2008,23(12):1175-1183
Background Postoperative ileus is a common condition after abdominal surgery. Many prokinetic drugs have been evaluated including osmotic
laxatives. The data on colon-stimulating laxatives are scarce. This prospective, randomized, double-blind trial investigates
the effect of the colon-stimulating laxative bisacodyl on postoperative ileus in elective colorectal resections.
Materials and methods Between November 2004 and February 2007, 200 consecutive patients were randomly assigned to receive either bisacodyl or placebo.
Primary endpoint was time to gastrointestinal recovery (mean time to first flatus passed, first defecation, and first solid
food tolerated; GI-3). Secondary endpoints were incidence and duration of nasogastric tube reinsertion, incidence of vomiting,
length of hospital stay, and visual analogue scores for pain, cramps, and nausea.
Results One hundred sixty-nine patients were analyzed, and 31 patients discontinued the study. Groups were comparable in baseline
demographics. Time to GI-3 was significantly shorter in the bisacodyl group (3.0 versus 3.7 days, P = 0.007). Of the single parameters defining GI-3, there was a 1-day difference in time to defecation in favor to the bisacodyl
group (3.0 versus 4.0 days, P = 0.001), whereas no significant difference in time to first flatus or tolerance of solid food was seen. No significant difference
in the secondary endpoints was seen. Morbidity and mortality did not differ between groups.
Conclusion Bisacodyl accelerated gastrointestinal recovery and might be considered as part of multimodal recovery programs after colorectal
surgery. 相似文献
60.