Short-term effects of a single intravitreal bevacizumab injection on retinal vessel calibre

Purpose: The aim was to investigate the short‐term effects of a single intravitreal bevacizumab injection on the retinal vessel calibre in patients with neovascular age‐related macular degeneration and in patients with diabetic macular oedema. Methods: Twelve patients with neovascular age‐related macular degeneration and eight patients with diabetic macular oedema were included in the study. All patients received an intravitreal injection of 1.25 mg bevacizumab. Red‐free fundus photographs (35°) were acquired with a fundus camera at baseline and one day, one week and one month after the intravitreal injection. Measurements of retinal vessel diameter were made of the supero‐temporal retinal venule and arteriole using the software available on the IMAGEnet program. Results: Although there appeared to be a trend towards vasoconstriction for the measurements in the diabetic macular oedema group (both for arterioles and venules at day 7) and the age‐related macular degeneration group (for venules at day 1 and for arterioles at day 7), it did not reach statistical significance (p > 0.05). Optical coherence tomography revealed a significant decrease in foveal thickness measurements in both groups at the one month visit compared with baseline. Conclusion: The results suggest that intravitreal injection of bevacizumab might induce retinal vasoconstriction; however, low numbers of subjects might have prevented the difference from reaching statistical significance. Further studies with a larger number of subjects would reveal the effect of intravitreal anti‐vascular endothelial growth factor treatment on retinal vessel diameters more clearly.     

Common tongue conditions affect quality of life: an issue to be recognized

Introduction

There is an increasing recognition that oral disorders might cause significant impact on life of patients. To date, there has been less focus on oral health?Crelated quality of life (OHR-QoL) measures in outpatient clinics for oral diseases.

Aim

This study was carried out to test the assumption that patients with common tongue conditions would report a worse OHR-QoL than controls.

Method

A total of 59 oral subjects with various tongue conditions and 44 controls were enrolled in this prospective study. Demographic, clinic, and laboratory findings of oral subjects were recorded, and an OHR-QoL questionnaire, named 14-item oral health impact profile (OHIP-14), was completed by oral subjects and controls at the outpatient clinics of four centers.

Results

Median of OHIP-14 total scores of the oral subjects with common tongue conditions was 11 and that of controls was 4 (P?=?0.00) indicating that OHR-QoL was worse in oral subjects than in controls. Most (n?=?39, 66%) of the oral subjects had mild to distressing pain. Eating was the most commonly affected function. Oral subjects were arbitrarily divided into two groups. Group 1 (n?=?22) included patients with tongue conditions which were associated with candidal infections and the other patients formed Group 2 (n?=?34). A significant difference between Group 1 and Group 2 was observed only with respect to functional limitation (P?=?0.027), indicating that oral subjects of Group 1 had more functional limitation.

Conclusion

Common tongue disorders were believed to be innocuous by most. When the influence of one of the most common form of oral disease (tongue conditions) on OHR-QoL was taken into consideration, OHR-QoL will provide an additional dimension and may help to improve the impact of a disease on an individual??s life. Moreover, we also encourage more extensive use of these OHR-QoL instruments for oral diseases at outpatient clinics.     

Improvement in physician pain perception with using pain scales

Background and aims

Acute pain is the most common reason for visits to the emergency department (ED). The underuse of analgesics occurs in a large proportion of ED patients. The physician’s accurate assessment of patients’ pain is a key element to improved pain management. The purpose of this study was to assess if physicians’ perception of pain can improve with looking at the pain score of the patient marked on VAS.

Study design

This was a single-center, cross-sectional prospective observational study, that took place in an academic ED.

Methods

All adult ED patients presenting with a painful condition were enrolled to the study. In the first phase of the study, the physician rated his/her opinion about the patient’s pain on a 100 mm VAS, in a blinded fashion to the patient’s pain score. In the second phase, the physician rated his/her opinion after looking at the pain scale marked by patient.

Results

587 patients (295, in first and 292, in second phase) were enrolled. The groups were not statistically different for demographic data. The physician’s perception of pain was lower than the patient’s pain score at both phases of the study. Insight of the patient’s pain score on VAS increased the physician’s pain perception significantly (p?=?0.03). During the second phase, physicians ordered significantly more analgesic medications to the patients (p?=?0.03).

Conclusion

The physicians’ perception of the patients’ pain differs significantly from the pain that the patient is experiencing. VAS helps to bring the physicians impression of pain perception to the level of pain that the patient is actually experiencing and resulted in ordering more analgesics to the patients. Implementation of a pain assessment tool can raise the physician’s perception of the pain and may improve pain management practices and patient satisfaction.

     

Letrozole-induced inflammatory arthritis and tendinopathy in pediatric rheumatology setting

Musculoskeletal symptoms associated with the use of aromatase inhibitors are a well-known side effect of these drugs and are more prevalent in postmenopausal women. Aromatase inhibitor-associated symptoms are not overt inflammatory processes so are described as arthralgia syndrome. In contrast, aromatase inhibitor-associated inflammatory conditions such as myopathies, vasculitis, and rheumatoid arthritis were also reported. To our knowledge, inflammatory arthritis or tendinopathy associated with aromatase inhibitors were not reported in children despite their increased off-label use in the pediatric setting. Herein, we report a girl with inflammatory arthritis and tendinopathy associated with letrozole treatment.     

Evaluation of plasma microRNA expressions in patients with juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, yet its etiology is unknown. It is known that microribonucleic acids (miRNAs) play a role in immunoregulation. We aimed to evaluate the plasma expression of some candidate miRNAs that are associated with the pathogenesis of autoimmunity. Thirty-one patients diagnosed with JIA and age-sex-matched 31 healthy children were enrolled for the study. The plasma levels of four candidate miRNAs (miRNA-16, miRNA-155, miRNA-204, and miRNA-451), which are known to be associated with autoimmunity, were examined in all the subjects. The plasma levels of miRNAs were measured with real-time PCR in the patients in active and inactive periods and in the healthy controls. The groups were compared with each other. The plasma miRNA-155 levels were found to increase in the JIA patients compared to the healthy controls, and it was statistically more significant in the inactive period. We found that the JIA patients had the higher levels of miRNA-16 and the lower levels of miRNA-204/miRNA-451 expressions compare with the control group, but there was no statistically significant difference. A statistically significant decrease in the plasma levels of miRNA-204 was found in the patients that were in inactive disease with only methotrexate therapy. The plasma miRNA expressions were compared in the JIA subtypes, and it was observed that miRNA-204 levels were higher in polyarticular JIA and miRNA-451 levels were higher in enthesitis-related arthritis without statistical significance. The significant alterations in the plasma expression of miRNA-155 and miRNA-204 suggest to us that these molecules may be related to the pathogenesis of JIA. More comprehensive and functional researches about the role of these molecules are needed in this regard.     

Can measurement of cervical length,fetal head position and posterior cervical angle be an alternative method to Bishop score in the prediction of successful labor induction?

Aim: The purpose of this study was to evaluate sonographic cervical length, posterior cervical angle and fetal head position in predicting successful induction of labor at term can be an alternative method to Bishop score.

Methods: This prospective observational study recruited 223 women with singleton gestations scheduled for induction of labor at 37–42 weeks. Parity, body mass index, Bishop score, fetal head position, cervical angle measurement and cervical length was investigated to predict successful labor induction. Multiple regression analysis was performed to determine the parameters in the prediction of successful vaginal delivery within 24 hours.

Results: Forty-five patients were excluded because of cesarean section performed for other reasons than arrest of dilation or fetal head descent (43 fetal distress, 2 cord prolapsus). Remaining 178 patients were divided into two groups according to duration of delivery time. 139 patients delivered within 24 hours were classified as group I, 39 patients delivered after 24 hours were classified as group II. Percentage of multiparity was statistically significantly higher in group I than in group II [59 (42.4%), 9 (23.0%) respectively, p?=?0.009]. Cervical length was statistically significantly shorter in group I than in group II [23.1?±?7.42?mm, 31.3?±?6.83?mm respectively, p?<?0.001]. Bishop score was statistically significantly higher in group I than in group II [3 (1–4), 1 (1–4) respectively, p?<?0.001]. Posterior cervical angle was statistically significantly higher in group I than in group II [100.1?±?17.2, 92.7?±?21.4 respectively, p?=?0.007]. According to the fetal head position, there was no statistically significant difference in labor duration between the groups (p?=?0.787). In the multivariate regression analysis of variables, multiparity, cervical length and Bishop score were statistically significantly predictive in successful labor induction.

Conclusion: Multiparity status, cervical length, posterior cervical angle and Bishop score can predict successful labor induction, but fetal head position is not predictive in successful labor induction.     

Determination of left ventricular filling pressure by new echocardiographic methods in patients with coronary artery disease

Aim The present study was designed to determine the reliability of the analysis of the time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity and mean systolic strain index, and comparing them with E/E′ in the detection of increased left ventricular end-diastolic pressure (LVEDP) in patients with coronary artery disease. Methods Eighty patients (mean age: 57.2 ± 11.5 years) referred for cardiac catheterization were studied. Patients were divided into 2 groups according to LVEDP (group 1: LVEDP > 20 mmHg, n = 39 patients; group 2: LVEDP ≤20 mmHg, n = 41 patients). From the mitral inflow, peak E velocity was calculated. With tissue Doppler echocardiography, early diastolic velocity (E′) measured from the septal, lateral, inferior and lateral mitral annulus and mean value of E′ and E/E′ ratio were calculated. The time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity (T_E′-E) was calculated. From the apical chambers, the peak systolic strain value of 16 left ventricular (LV) segments was measured and the mean of these 16 segments was calculated and referred to as mean systolic strain index. Results The patients with increased LVEDP (group 1) had a higher E/E′ ratio (13.8 ± 3.4 vs. 9.9 ± 2.8, P < 0.001) and lower mean systolic strain index (11.8 ± 3.4 % vs. 13.5 ± 3.6 %, P = 0.038) than patients in group 2. The sensitivity of E/E′ > 13.42 for identifying LVEDP > 20 mmHg was 71%, with a specificity of 89%. The sensitivity of a mean systolic strain index < 10.57% for identifying LVEDP > 20 mmHg was 44%, with a specificity of 83%. T_E′-E was not significantly different between the two groups. Conclusion The decreased longitudinal function of the left ventricle is related to increased LVEDP. The E/E’ ratio, which in recent years has been used for the prediction of LV filling pressures, was a better predictor for increased LVEDP than the mean systolic strain score index and the time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity in patients with coronary artery disease.