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21.
目的 研究美托洛尔对室性心律失常的疗效及其对心率变异性的影响。方法 对 36例Holter证实有频繁室性心律失常的患者 ,测定服药前后HRVI ,以统计学方法进行分析。结果 应用美托洛尔治疗后 ,室性心律失常明显减少 ,心率变异指数明显增加 ,较用药前有显著差异 (P <0 0 1)。结论 美托洛尔对室性心律失常疗效显著 ,并使心率变异性增加 相似文献
22.
药用辅料在制剂中的应用概述 总被引:1,自引:0,他引:1
药用辅料是药物制剂的基础材料的重要的组成部分,在制剂型和生产中起着关键作用,它不仅赋予药物一定剂型,并且与提高药物的疗效,降低毒副作用有很大的关系,因此,研究开发,合理应用辅仅可提高药物制剂质量和生产技术水平,而且可取得较大的社会及经济效益。 相似文献
23.
采用化学共沉淀法制备锑掺杂二氧化锡(ATO)超细导电粉体,研究了反应温度,滴定终点pH值,掺锑量及锻炼温度对粉体导电性的影响,并对实验结果进行了讨论。 相似文献
24.
探讨了以H2SO4和CH2OHCH2Cl为酸解介质时,氯化法金红石型钛白粉表面包铝的行为及形态特征。利用正交实验研究了包膜过程中,熟化pH、熟化时间以及温度对包铝钛白粉白度的影响。氯化法金红石型钛白粉浆在pH为10时,Zeta电位最大,在水中达到最佳分散,利用H2OHCH2Cl作为酸解介质时,浆液中的均相成核得到显著抑制,钛白粉表面的包膜质量得到明显改善。以稀硫酸作为酸解介质时,随熟化温度升高和熟化时间的延长,钛白粉包覆效果明显改善,白度值明显升高。 相似文献
25.
目的建立测定血浆和尿样中5-氨基水杨酸(5-ASA)及代谢物乙酰-5-氨基水杨酸(Ac-5-ASA)浓度的HPLC方法,并进行5-ASA缓释片Pentasa的人体药动学研究.方法使用荧光检测器,以丙酰-4-氨基水杨酸为内标,用衍生化法使样品中的5-ASA丙酰化,甲醇沉淀蛋白后上清液直接进样.色谱柱为PhenomenexLunaTMC18,流动相为0.1mo1/L乙酸溶液乙腈三乙胺(460400.4,V/V/V)的混合液.测定6位健康志愿者口服1000magPentasa后血药浓度和尿药浓度.结果血浆中5-ASA及代谢物的线性范围为0.01~10μg/ml,尿样中为0.2~200μg/ml,血浆和尿中药物与代谢物的回收率在95.3%~106.2%之间,日内日间相对标准差均在052%~9.22%范围内.Pentasa口服后5-ASA和Ac-5-ASA的血药浓度在3~4h内达到峰值,分别为1.55和3.11μg/rl,AUC分别为6.90和26.32μg/(ml@h),60h内尿中排泄了口服剂量37.1%的药物.结论方法简便,灵敏度和准确度高,可用于5-ASA制剂的药物动力学研究. 相似文献
26.
Helvacı Özant Korucu Berfu Gonul Ipek İsik Arınsoy Turgay Guz Galip Derici Ulver 《International urology and nephrology》2021,53(1):105-109
International Urology and Nephrology - The number of kidney biopsies (KB) performed in elderly patients has been increasing. Safety and usefulness of elderly KB have been well established, whereas... 相似文献
27.
Asiye İzem Sandal Hatice Şenlikci Merve Yılmazer Burcu Kartal Bedia Palabıyık Özen Banu Özdaş 《Andrologia》2021,53(5):e14032
The aim of the study was to investigate the efficiency of ram seminal plasma and fetal calf serum on freezing of buck semen. Twenty ejaculates were collected using an electro-ejaculator and split into six groups. While FCS additive was not used in A1, A2 and A3 groups, 10% FCS was added to B1, B2 and B3 groups. These groups were then edited according to whether the buck or ram SP was involved. The design of the groups was done as follows: Group A1 (control 1), group A2 without buck SP, group A3 containing ram SP instead of buck SP. Groups B1 (control 2), B2 and B3 were the FCS added forms of these groups. Progressive sperm motility percentages in Group A1 and Group B2 were found to be higher when compared to the lowest Group B3. There were no significant differences between the groups in neither the levels of reactive oxygen species nor the enzyme and glutathione activities. In conclusion, the lack of statistical difference between the groups suggested that despite the supplements used but only when the buck spermatozoa structure was healthy, the cell could preserve acrosome, DNA and the integrity of membrane. 相似文献
28.
29.
Haonan Yu Ling Liu Qiusong Chen Qing He Yansheng Li Ying Wang Shuo Gao 《Orthopaedic Surgery》2021,13(3):791
ObjectiveTo assess and compare the performance of fluorine‐18‐labeled fluorodeoxyglucose positron emission tomography (18F‐FDG‐PET/ CT) and gallium‐68‐labeled tetraazacyclododecanetetraacetic acid‐DPhe1‐Tyr3‐octreotate (68Ga‐ DOTATATE) PET/CT in the targeted imaging of culprit tumors causing osteomalacia.MethodsThis was a clinical retrospective analysis. We analyzed 13 patients (five men, eight women; mean age, 49 years; range, 19–55 years) with suspicion of tumor‐induced osteomalacia (TIO) between March 2017 and October 2019. All patients underwent two functional imaging methods to locate the culprittumors. Studies were performed on a PET/CT scanner. The injection doses of 18F‐ FDG and 68Ga‐DOTATATE were 0.5mCi/kg and approximately 5.0mCi, respectively. In the two scans, the whole body was captured from head to toe 45 to 60 min after intravenous tracer injection. 68Ga‐DOTATATE PET/CT and 18F‐FDG PET/CT imaging results locate culprit tumors according to the following criteria: (i) abnormal foci uptake concentration was observed locally, and the uptake level was higher than the background level of the right lobe of the liver; (ii) combined CT showed or did not have obvious abnormal density changes; and (iii) non‐specific ingestion lesions due to fracture, arthritis, necrosis of femoral head are excluded. Compared with the results of pathological examination and clinical follow‐up, the sensitivity, specificity and accuracy of 68Ga‐DOTATATE PET/CT imaging and 18F‐FDG PET/CT imaging for TIO were analyzed.ResultsAll patients had symptoms of osteomalacia and hypophosphatemia. The lag time (symptoms to PET diagnosis) ranged from 2 to 12 years. There were eight cases of TIO patients and five cases of non‐TIO patients confirmed by surgery, pathology and follow‐up. Among the eight TIO patients, there were six cases (75.0%) of PMTs, one case (12.5%) of giant cell tumor, one case (12.5%) of hemangiopericutoma. Most (n = 6, 75.0%) of the confirmed tumors in our patient population were in the lower extremities, followed by craniofacial regions (n = 1, 12.5%), and torso (n = 1, 12.5%), respectively. Among the five non‐TIO patients, there were two cases of Fanconi syndrome, one case of rickets, and two cases of sporadic osteomalacia hypophosphorus. The culprit tumors could be located either in the bone (n = 5, 62.5%) or the soft tissue (n = 3, 37.5%). 18F‐FDG PET/CT was able to localize the tumor in six (6/13, 46.1%) patients. 68Ga‐DOTATATE PET/CT detected tumor in 8 (83.3%) of 13 patients. The sensitivity of 68Ga‐DOTATATE PET/CT imaging and 18F‐FDG PET/CT imaging in the evaluation of TIO in our patient population were 100% (8/8) vs 75% (6/8). The specificity of the two different methods was 80% (4/5). The overall accuracy was 92.3% (12/13) vs 76.9% (10/13).Conclusions 68Ga‐DOTATATE PET/CT is very effective in assessing hypophosphatemia patients with TIO typical symptoms compared with 18F‐FDG. Therefore, in clinically suspected cases of hypophosphatemic osteomalacia, 68Ga‐DOTATATE PET/CT should be preferred as an imaging modality investigation to avoid delay in the treatment of this disease. 相似文献
30.
臀上动脉深上支髂骨骺移植的解剖学研究 总被引:16,自引:1,他引:16
目的 :为带血供的髂骨骺移植提供解剖学依据。方法 :在 40侧经动脉灌注红色乳胶的成人臀部标本以及 2侧儿童标本上 ,观测臀上动脉深上支的行程、分支及滋养支 ;选用 5 0块髋骨 ,观察髂骨嵴前外侧部的滋养孔。结果 :儿童臀上动脉深上支的分支、分布与成人相似 ,位于臀中肌深面和臀小肌上缘 (相当臀前线 ) ,循髂骨嵴弓形向前 ,达髂前上嵴 ,沿途分出平均 (4 .2± 1.1)支外径 0 .5~ 1.1mm的髂嵴支 ,分布髂嵴骨膜 ,并发细小分支进入滋养孔。从髂前上棘至结节区 ,在距髂嵴缘下方 2cm范围内 ,平均有(2 2 .4± 6.7)个滋养孔。结论 :以臀上动脉深上支及其分支为蒂 ,在髂嵴前部可切取带骺骨瓣 ,以修复长管骨骨骺缺损。 相似文献