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91.
Etiology and long‐term rebleeding of endoscopic ulcerative lesions in the small bowel in patients with obscure gastrointestinal bleeding: A multicenter cohort study 下载免费PDF全文
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93.
94.
Tohru Akahoshi Mamoru Ishikawa Michio Takahashi Naho Sekiyama Kazuko Hasegawa Kiyoharu Watanabe Yoshihiro Ishihara Hirobumi Kondo 《Modern rheumatology / the Japan Rheumatism Association》1997,7(1):55-60
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system caused by an opportunistic infection of the JC virus. PML is known to occur in immunocompromised patients. A patient with systemic lupus erythematosus (SLE) who developed PML during i.v. cyclophosphamide and methylprednisolone pulse therapy is described. The pertinent literature relating to complication of SLE by PML is discussed. 相似文献
95.
Junichi Saito Hironori Ishihara Eiji Hashiba Hirobumi Okawa Tomoyuki Kudo Masahiro Sawada Toshihito Tsubo Kazuyoshi Hirota 《Journal of anesthesia》2013,27(4):512-520
Purpose
Appropriate adjustment of cardiac preload is essential to maintain cardiac output (CO), especially in patients after cardiac surgery. This study was intended to determine whether index of right ventricular end-diastolic volume (RVEDVI), corrected RVEDVI using ejection fraction (cRVEDVI), index of initial distribution volume of glucose (IDVGI), or cardiac filling pressures are correlated with cardiac index (CI) following cardiac surgery in the presence or absence of arrhythmias.Methods
Eighty-six consecutive cardiac surgical patients were studied. Patients were divided into two groups: the non-arrhythmia (NA) group (n = 72) and the arrhythmia (A) group (n = 14). Three sets of measurements were performed: on admission to the ICU and daily on the first 2 postoperative days. The relationship between each cardiac preload variable and cardiac index (CI) was evaluated. A p value less than 0.05 indicated statistically significant differences.Results
Each studied variable was not different between the two groups immediately after admission to the ICU. cRVEDVI had a linear correlation with CI in both group (NA group: r = 0.67, n = 216, p < 0.001; A group: r = 0.77, n = 42, p < 0.001), but RVEDVI had a poor correlation with CI (NA group: r = 0.27, n = 216, p < 0.001; A group: r = 0.19, n = 42, p = 0.036). IDVGI had a linear correlation with CI (NA group: r = 0.49, n = 216, p < 0.001; A group: r = 0.61, n = 42, p < 0.001), Cardiac filling pressures had no correlation with CI.Conclusion
Our results demonstrated that cRVEDVI and IDVGI were correlated with CI in the presence or absence of arrhythmias. cRVEDVI and IDVGI have potential as indirect cardiac preload markers following cardiac surgery. 相似文献96.
Antitumor effect of antitissue factor antibody‐MMAE conjugate in human pancreatic tumor xenografts 下载免费PDF全文
Yoshikatsu Koga Shino Manabe Yoshiyuki Aihara Ryuta Sato Ryo Tsumura Hikaru Iwafuji Fumiaki Furuya Hirobumi Fuchigami Yuki Fujiwara Yohei Hisada Yoshiyuki Yamamoto Masahiro Yasunaga Yasuhiro Matsumura 《International journal of cancer. Journal international du cancer》2015,137(6):1457-1466
Tissue factor (TF) triggers the extrinsic blood coagulation cascade and is highly expressed in various types of cancer. In this study, we investigated the antitumor effect of an antibody–drug conjugate (ADC) consisting of an anti‐TF monoclonal antibody and monomethyl auristatin E (MMAE). MMAE was conjugated to an anti‐human TF or anti‐mouse TF antibody using a valine‐citrulline linker that could be potentially hydrolyzed by cathepsin B in the acidic environment of the lysosome. The cytotoxic and antitumor effects of the ADCs against four pancreatic cancer cell lines were analyzed. Both the ADC with the anti‐human TF antibody and that with the anti‐mouse TF antibody were stable under physiological conditions. The anti‐human ADC was internalized in TF‐expressing human tumor cell lines, followed by effective MMAE release. The half maximal inhibitory concentration (IC50) of MMAE was approximately 1 nM for all of the cell lines used. Meanwhile, the IC50 of anti‐human ADC was 1.15 nM in the cell lines showing high TF expression, while exceeding 100 nM in the cells showing low TF expression levels. Anti‐human ADC with passive and active targeting ability exerted significant suppression of tumor growth as compared to that observed in the saline group (p < 0.01). Also significant tumor growth suppressions were seen at the anti‐mouse ADC and control ADC groups compared to the saline group (p < 0.01) due to EPR effect. Because various clinical human cancers express highly amount of TF, this new anti‐TF ADC may deserve a clinical evaluation. 相似文献
97.
Hiroo Imazu Naoki Mori Keisuke Kanazawa Masafumi Chiba Hirobumi Toyoizumi Yuichi Torisu Seita Koyama Shoryoku Hino Tiing Leong Ang Hisao Tajiri 《Digestive diseases and sciences》2014,59(8):1909-1916
Background and Aims
Differentiation of gallbladder (GB) carcinoma from benign GB wall thickening is challenging. The recent introduction of second-generation ultrasonic contrast agents has made contrast harmonic imaging with EUS possible. The aim of our study was to evaluate the utility of contrast-enhanced harmonic EUS (CH-EUS) for the differential diagnosis of GB wall thickening.Methods
Thirty-six consecutive patients with GB wall thickening imaged by CH-EUS and then underwent surgery were enrolled in this study. After the lesions were observed with conventional harmonic EUS (H-EUS), CH-EUS was performed with intravenous injection of 0.015 ml/kg of Sonazoid. Three reviewers with various levels of experience of EUS (Reviewer A: experienced endosonographer, B: EUS trainee, C: experienced gastroenterologist with expertise in transabdominal ultrasound but no EUS experience) were blinded to findings of recorded video of H-EUS and CH-EUS. The diagnostic accuracy of H-EUS and CH-EUS for malignant GB wall thickening was compared.Results
Final diagnoses based on surgical histology were GB carcinoma in 16, cholecystitis in 11, adenomyomatosis in 6 and cholesterolosis in 3. Overall sensitivity, specificity and accuracy for diagnosing malignant GB wall thickening of H-EUS and CH-EUS were 83.3 versus 89.6, 65 versus 98 % (p < 0.001) and 73.1 versus 94.4 % (p < 0.001). The inter-observer agreement for H-EUS was moderate (κ = 0.51), whereas that for CH-EUS was substantial (κ = 0.77). The inhomogeneous enhanced pattern on CH-EUS was a strong predictive factor of malignant GB wall thickening.Conclusion
CH-EUS has the potential to improve the preoperative diagnostic accuracy and inter-observer agreement in the differential diagnosis of GB wall thickening. 相似文献98.
Dr. Tomio Narisawa M.D. Hisashi Kusaka M.D. Yoshihiko Yamazaki M.D. Masahiro Takahashi M.D. Hirobumi Koyama M.D. Kenji Koyama M.D. Yoko Fukaura B.S. Akira Wakizaka M.D. 《Diseases of the colon and rectum》1990,33(10):840-845
The relationship of prostaglandin E
2,of which a large amount is produced in various neoplasms, and hematogenous distant metastases was investigated in a total of 44 colorectal cancer patients because of its varied pathophysiologic potentials. The authors found significantly high levels of PGE
2
in local venous blood draining the carcinoma and in peripheral blood in cases with liver or lung metastasis, as well as a significantly large amount of PGE
2
production in the carcinoma tissue. The results suggest that increased local blood PGE
2
could enhance the metastasis formation, and increased peripheral blood PGE
2
may be useful in the detection of such metastasis in colorectal cancer.Supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare, Japan. 相似文献
99.
100.
Daisuke Fuse Takaaki Nakamoto Hiroshi Harasawa Suguru Machida Hirohisa Amano Takeshi Yoshida Toshiya Mathuda Takahide Nakajima Hideyo Kuga Suguru Machida Hidehiko Suzuki Hirobumi Akiba Noboru Kaneko 《Geriatrics & Gerontology International》2002,2(2):110-114
An oxygen concentrator that can be powered by a car battery was clinically evaluated. The oxygen concentrator was used on a 67-year-old man with sequelae of pulmonary tuberculosis who was receiving long-term home oxygen therapy (HOT) after long-term use of 4.7 years. His work required automobile trips over long distances. The equipment used was an adsorption-type oxygen concentrator capable of operating on a DC 12 V power supply, which could be powered from a residential power outlet (AC 100 V) using a dedicated voltage converter. Using this equipment, he was capable of driving himself in comfort for 2 hours or longer, over a period of 4 years. Furthermore, it was possible to stay in a hotel during a trip, inhaling oxygen generated by the equipment. Hereafter, this equipment should enable or facilitate long-distance driving, travel and lodging for HOT patients. 相似文献