Meta analysis of the treatment-related factors of external apical root resorption

OBJECTIVE: To elucidate possible treatment-related etiological factors--such as, duration of treatment and apical displacement--for external root resorption. DESIGN: Meta-analysis of the available English-language literature. INCLUSION & EXCLUSION CRITERIA: Papers with a sample size > 10, fixed appliances, pre- and post-operative radiographs, and apical displacement recorded were included. History of trauma, prior root resorption and endodontic treatment were excluded. Appropriateness of these selections was tested with a 'funnel plot' analysis. OUTCOME MEASURE: Correlations between root resorption, apical displacement, and treatment duration. RESULTS: Mean apical root resorption was strongly correlated with total apical displacement (r = 0.822) and treatment duration (r = 0.852). CONCLUSION: The treatment-related causes of root resorption appear to be the total distance the apex had moved and the time it took.     

The office hysteroscopic evaluation of postmenopausal patients

Objective The objective was to characterize postmenopausal women with endometrial polyps and to evaluate their significance.Methods The study population included all consecutive postmenopausal patients with a diagnosis of endometrial polyps. Demographic, medical and gynecological data were assessed with regard to the endometrial histologic findings.Results Of the 181 eligible patients, 34 had endometrial hyperplasia (4 cases of them had endometrial carcinoma). The 144 patients using hormone replacement therapy had significantly higher rate of endometrial hyperplasia than non-hormone users (p<0.006). No differences were observed among the endometrial histological categories for any of the presenting symptoms and signs, ultrasonographic findings, or medical histories.Conclusion Postmenopausal endometrial polyps is a common, mostly benign entity. However, the relatively high rate of concomitant endometrial hyperplasia, especially in patients receiving hormone replacement therapy, dictates a thorough histological evaluation in all cases.     

Osteoarthritis--a rare indication for atlantoaxial fusion. A case report and review of the literature

The authors report a case of C1-C2 fusion which was performed in a 64-year-old woman with unilateral atlantoaxial osteoarthritis, who consulted because of incapacitating occipital pain and decreased cervical rotation without neurological deficit. The diagnosis of unilateral C1-C2 osteoarthritis was confirmed by an open-mouth radiograph, a bone-scan, a computerised tomography scan, and magnetic resonance imaging. C1-C2 fusion was performed using a computer assisted navigation system and posterior instrumentation. This resulted in marked relief of pain, and distinct improvement in quality of life. The prevalence of atlantoaxial osteoarthritis is about four per cent in patients suffering from peripheral or spinal osteoarthritis. However, many primary-care providers are not familiar with this entity. C1-C2 fusion remains rare, due to the difficulties related to the diagnosis of atlantoaxial osteoarthritis, its established non-operative treatment options, and the fact that it has not received adequate attention in the orthopaedic literature. However, based on review of the literature, it can be stated that C1-C2 fusion is an effective and safe procedure providing distinct reduction of pain and increased quality of life in case of failure of conservative treatment.     

Seroprevalence and some correlates of Helicobacter pylori at adult ages in Gülveren Health District, Ankara, Turkey

The purpose of the study was to detect the frequency and distribution of Helicobacter pylori in the Gülveren Health Centre service area among residents aged between 25 and 64 years and to evaluate the relation of H. pylori infections with general health status, socioeconomic status, and some lifestyle habits. The study included a representative sample of Gülveren Health Centre residents, aged between 25 and 64 years. A stratified random sample of 1672 individuals was selected for study purposes out of 10,569 residents, stratified by age and gender. A standardized questionnaire was completed for all study participants using a face-to-face interview and all participants were invited to the local health centre for a thorough physical examination and blood tests. The overall prevalence of H. pylori was found to be 77.5 % among individuals aged between 25 and 64 years. The frequency of H. pylori was higher among individuals with low socioeconomic status; those who migrated to Ankara after the age of 20 years; members of large families (household size of 4 or above); non-alcohol drinkers; and those who regularly drink tea.     

Prognostic significance of seizure in patients with glioblastoma multiforme

BACKGROUND: Several prognostic factors have been described but there are few studies evaluating the prognostic importance of seizure in patients with glioblastoma multiforme (GBM). AIMS: To evaluate the prognostic importance of seizure at the time of the diagnosis of glioblastoma multiforme (GBM) and compare it with other known prognostic factors. SETTINGS AND DESIGN: Between January 1994 and December 2000, 81 patients underwent irradiation for intracranial GBM at our institution. The criteria for inclusion in this study were biopsy-proven GBM, being treated for primary disease. Seventy-six patients were retrospectively evaluated and the remaining five patients could not be enrolled due to lack of details. MATERIAL AND METHODS: The prognostic importance of age, sex, performance status, a history of seizure at diagnosis, extent of surgery, radiotherapy field and dose were studied. STATISTICAL ANALYSIS: The Kaplan-Meier method, the Log rank test, the Cox proportional hazard model and the Mann-Whitney U test were used for statistical analysis. RESULTS: Survival at first and second years was 19.74% and 4.81%, respectively. Univariate analysis revealed age, performance status, history of seizure, and radiotherapy dose as significant prognostic factors and with multivariate analysis age, history of seizure and radiotherapy dose were positive prognostic factors. CONCLUSION: This study concluded that in GBM, history of seizure prior to diagnosis of GBM was a positive prognostic factor.