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51.
Evaluation of the Coulter three-part differential screen 总被引:3,自引:0,他引:3
An evaluation of the Coulter Electronics, Inc. (Hialeah, FL) three-part differential screen (3PD) was undertaken to determine the performance characteristics of this system. The 3PD measures white blood cell (WBC) volumes and, by automatic analysis of the resultant WBC histogram, produces a determination of the number and percent of lymphocytes, mononuclear cells, and granulocytes. A group of 984 random patient blood samples was tested. The overall review rate (samples requiring some further analysis or review) was 42%. The main source of false negatives on the 3PD was eosinophilia: 5 out of 22 instances of eosinophilia greater than 750/microL were not flagged. The precision of the three parameters, measured as percent coefficient of variation, was 3.3% for lymphocytes, 14.2% for mononuclear cells, 3.1% for granulocytes, and 2.4% for the total WBC. The stability of blood samples was acceptable for up to eight hours at room temperature (less at 4 degrees C). 相似文献
52.
Factors affecting the detection of enteroviruses in cerebrospinal fluid with coxsackievirus B3 and poliovirus 1 cDNA probes. 总被引:4,自引:6,他引:4 下载免费PDF全文
H A Rotbart M J Levin L P Villarreal S M Tracy B L Semler E Wimmer 《Journal of clinical microbiology》1985,22(2):220-224
Enteroviruses are common pathogens of meningitis and encephalitis, and infections are often difficult to distinguish clinically from bacterial and herpetic infections of the central nervous system. An array of enteroviruses added to cerebrospinal fluid in reconstruction experiments were detected by a dot hybridization assay. Optimal handling and processing conditions for infected cerebrospinal fluid were established, and the effect on the hybridization reaction of humoral and cellular components of the inflammatory response was determined. Six hybridization probes, derived from poliovirus 1 and coxsackievirus B3, were then tested, singly and in combinations, to optimize the sensitivity and spectrum of the assay. Implications for enteroviral taxonomy based on these experiments are discussed. 相似文献
53.
An assessment of three simple methods of typing Proteus strains is described. The methods chosen were biochemical typing, bacteriocine typing, and typing by means of the Dienes phenomenon. Dienes typing was deemed to be superior to biochemical typing and bacteriocine typing.A brief discussion on the relationship between the Dienes phenomenon and bacteriocine production is appended. 相似文献
54.
Psycho-Behavioural Segmentation in Food and Nutrition: A Systematic Scoping Review of the Literature
Eva L. Jenkins Samara Legrand Linda Brennan Annika Molenaar Mike Reid Tracy A. McCaffrey 《Nutrients》2021,13(6)
Inadequate dietary intakes are a key modifiable risk factor to reduce the risk of developing non-communicable diseases. To encourage healthy eating and behaviour change, innovative public health interventions are required. Social marketing, in particular segmentation, can be used to understand and target specific population groups. However, segmentation often uses demographic factors, ignoring the reasons behind why people behave the way they do. This review aims to explore the food and nutrition related research that has utilised psycho-behavioural segmentation. Six databases from were searched in June 2020. Inclusion criteria were: published 2010 onwards, segmentation by psycho-behavioural variables, outcome related to food or nutrition, and healthy adult population over 18 years. 30 studies were included; most were quantitative (n = 28) and all studies used post-hoc segmentation methods, with the tools used to segment the population varying. None of the segments generated were targeted in future research. Psycho-behavioural factors are key in understanding people’s behaviour. However, when used in post-hoc segmentation, do not allow for effective targeting as there is no prior understanding of behaviours that need to change within each segment. In future, we should move towards hybrid segmentation to assist with the design of interventions that target behaviours such as healthy eating. 相似文献
55.
Vivolo-Kantor Alana M. Niolon Phyllis Holditch Estefan Lianne Fuino Le Vi Donna Tracy Allison J. Latzman Natasha E. Little Todd D. Lang Kyle M. DeGue Sarah Tharp Andra Teten 《Prevention science》2021,22(2):162-162
Prevention Science - The article “Middle School Effects of the Dating Matters® Comprehensive Teen Dating Violence Prevention Model on Physical Violence, Bullying, and Cyberbullying: a... 相似文献
56.
Frederick Thurston Drake Melanie L. Lyden Jennifer H. Kuo Wen T. Shen Lilah F. Morris-Wiseman Sally E. Carty Tracy S. Wang 《Surgery》2021,169(3):488-495
BackgroundApproximately 80% of general surgery residents undertake some form of fellowship training. Our objective was to characterize goals and burdens of the interview process among applicants to Comprehensive Endocrine Surgery Fellowship programs.MethodsParticipants included trainees from 2013 to 2019. Results for ranking questions are presented as a mean rank reported out of the total number of selections.ResultsResponse rate was 54% (n = 75). The most important goal for interviews was meeting the faculty (mean rank 2.4/9), followed by “behind the scenes information” and “make a good impression” (mean rank 3.6 and 3.7, respectively). The most substantial burden for the applicant was expense (mean rank 2.1/7), followed by time away from residency (mean rank 3.1/7). The economic burden of 51% of the applicants was $2,500 to $7,500. Geographic location and expense were the top 2 reasons applicants declined offers of interviews. Despite the process, 76% of respondents indicated that no improvements to the interview process are necessary. Alternative strategies such as videoconferencing or centralized interviews received little support (<10%).ConclusionDespite identifying several burdens, survey respondents believed that in-person interviews are an integral component of the fellowship application process. Indeed, 70% of applicants do not have a first-choice program before interviews, and meeting the faculty is ranked as the greatest priority goal. Our data illustrate the importance of individual specialties evaluating and optimizing their own processes for fellowship interviews. 相似文献
57.
Carlos R Ferreira Dillon Kavanagh Ralf Oheim Kristin Zimmerman Julian Stürznickel Xiaofeng Li Paul Stabach R Luke Rettig Logan Calderone Colin MacKichan Aaron Wang Hunter A Hutchinson Tracy Nelson Steven M Tommasini Simon von Kroge Imke AK Fiedler Ethan R Lester Gilbert W Moeckel Björn Busse Thorsten Schinke Thomas O Carpenter Michael A Levine Mark C Horowitz Demetrios T Braddock 《Journal of bone and mineral research》2021,36(5):942-955
Inactivating mutations in human ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) may result in early-onset osteoporosis (EOOP) in haploinsufficiency and autosomal recessive hypophosphatemic rickets (ARHR2) in homozygous deficiency. ARHR2 patients are frequently treated with phosphate supplementation to ameliorate the rachitic phenotype, but elevating plasma phosphorus concentrations in ARHR2 patients may increase the risk of ectopic calcification without increasing bone mass. To assess the risks and efficacy of conventional ARHR2 therapy, we performed comprehensive evaluations of ARHR2 patients at two academic medical centers and compared their skeletal and renal phenotypes with ENPP1-deficient Enpp1asj/asj mice on an acceleration diet containing high phosphate treated with recombinant murine Enpp1-Fc. ARHR2 patients treated with conventional therapy demonstrated improvements in rickets, but all adults and one adolescent analyzed continued to exhibit low bone mineral density (BMD). In addition, conventional therapy was associated with the development of medullary nephrocalcinosis in half of the treated patients. Similar to Enpp1asj/asj mice on normal chow and to patients with mono- and biallelic ENPP1 mutations, 5-week-old Enpp1asj/asj mice on the high-phosphate diet exhibited lower trabecular bone mass, reduced cortical bone mass, and greater bone fragility. Treating the Enpp1asj/asj mice with recombinant Enpp1-Fc protein between weeks 2 and 5 normalized trabecular bone mass, normalized or improved bone biomechanical properties, and prevented the development of nephrocalcinosis and renal failure. The data suggest that conventional ARHR2 therapy does not address low BMD inherent in ENPP1 deficiency, and that ENPP1 enzyme replacement may be effective for correcting low bone mass in ARHR2 patients without increasing the risk of nephrocalcinosis. © 2021 American Society for Bone and Mineral Research (ASBMR). 相似文献
58.
Jeremy Yuen-Chun Teoh Terry Cheuk-Fung Yip Grace Chung-Yan Lui Vincent Wai-Sun Wong Viola Chi-Ying Chow Tracy Hang-Yee Ho Timothy Chun-Man Li Yee-Kit Tse Peter Ka-Fung Chiu Chi-Fai Ng David Shu-Cheong Hui Henry Lik-Yuen Chan Cheuk-Chun Szeto Grace Lai-Hung Wong 《Journal of the American Society of Nephrology : JASN》2021,32(4):961
BackgroundSevere acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19) are closely related. The effect of AKI on the clinical outcomes of these two conditions is unclear.MethodsThis retrospective, territory-wide cohort study used an electronic public healthcare database in Hong Kong to identify patients with SARS or COVID-19 by diagnosis codes, virologic results, or both. The primary endpoint was a composite of intensive care unit admission, use of invasive mechanical ventilation, and/or death.ResultsWe identified 1670 patients with SARS and 1040 patients with COVID-19 (median ages, 41 versus 35 years, respectively). Among patients with SARS, 26% met the primary endpoint versus 5.3% of those with COVID-19. Diabetes mellitus, abnormal liver function, and AKI were factors significantly associated with the primary endpoint among patients with either SARS or COVID-19. Among patients with SARS, 7.9%, 2.1%, and 3.7% developed stage 1, stage 2, and stage 3 AKI, respectively; among those with COVID-19, 6.6%, 0.4%, and 1.1% developed stage 1, stage 2, and stage 3 AKI, respectively. In both groups, factors significantly associated with AKI included diabetes mellitus and hypertension. Among patients with AKI, those with COVID-19 had a lower rate of major adverse clinical outcomes versus patients with SARS. Renal function recovery usually occurred within 30 days after an initial AKI event.ConclusionsAKI rates were higher among patients with SARS than those with COVID-19. AKI was associated with major adverse clinical outcomes for both diseases. Patients with diabetes mellitus and abnormal liver function were also at risk of developing severe consequences after SARS and COVID-19 infection. 相似文献
59.
Herremans Kelly M. Cribbin Morgan P. Riner Andrea N. Neal Dan W. Hollen Tracy L. Clevenger Pamela Munoz Derly Blewett Shannon Giap Fantine Okunieff Paul G. Mendenhall Nancy P. Bradley Julie A. Mendenhall William M. Mailhot-Vega Raymond B. Brooks Eric Daily Karen C. Heldermon Coy D. Marshall Julia K. Hanna Mariam W. Leyngold Mark M. Virk Sarah S. Shaw Christiana M. Spiguel Lisa R. 《Annals of surgical oncology》2021,28(10):5775-5787
Annals of Surgical Oncology - Breast cancer-related lymphedema (BCRL) is a source of postoperative morbidity for breast cancer survivors. Lymphatic microsurgical preventive healing approach... 相似文献
60.