全文获取类型
收费全文 | 2616篇 |
免费 | 205篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 59篇 |
妇产科学 | 20篇 |
基础医学 | 322篇 |
口腔科学 | 26篇 |
临床医学 | 169篇 |
内科学 | 835篇 |
皮肤病学 | 36篇 |
神经病学 | 177篇 |
特种医学 | 104篇 |
外科学 | 550篇 |
综合类 | 8篇 |
预防医学 | 39篇 |
眼科学 | 74篇 |
药学 | 103篇 |
中国医学 | 1篇 |
肿瘤学 | 310篇 |
出版年
2023年 | 25篇 |
2022年 | 44篇 |
2021年 | 108篇 |
2020年 | 55篇 |
2019年 | 66篇 |
2018年 | 89篇 |
2017年 | 66篇 |
2016年 | 86篇 |
2015年 | 75篇 |
2014年 | 105篇 |
2013年 | 101篇 |
2012年 | 192篇 |
2011年 | 219篇 |
2010年 | 119篇 |
2009年 | 105篇 |
2008年 | 178篇 |
2007年 | 151篇 |
2006年 | 140篇 |
2005年 | 155篇 |
2004年 | 145篇 |
2003年 | 142篇 |
2002年 | 147篇 |
2001年 | 40篇 |
2000年 | 26篇 |
1999年 | 27篇 |
1998年 | 30篇 |
1997年 | 24篇 |
1996年 | 20篇 |
1995年 | 22篇 |
1994年 | 25篇 |
1993年 | 12篇 |
1992年 | 11篇 |
1991年 | 13篇 |
1990年 | 6篇 |
1989年 | 8篇 |
1988年 | 7篇 |
1987年 | 11篇 |
1986年 | 9篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1978年 | 4篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1968年 | 2篇 |
1966年 | 1篇 |
1965年 | 2篇 |
排序方式: 共有2846条查询结果,搜索用时 15 毫秒
41.
Satoshi Kutsuna Yasuyuki Kato Meng Ling Moi Akira Kotaki Masayuki Ota Koh Shinohara Tetsuro Kobayashi Kei Yamamoto Yoshihiro Fujiya Momoko Mawatari Tastuya Sato Junwa Kunimatsu Nozomi Takeshita Kayoko Hayakawa Shuzo Kanagawa Tomohiko Takasaki Norio Ohmagari 《Emerging infectious diseases》2015,21(3):517-520
After 70 years with no confirmed autochthonous cases of dengue fever in Japan, 19 cases were reported during August–September 2014. Dengue virus serotype 1 was detected in 18 patients. Phylogenetic analysis of the envelope protein genome sequence from 3 patients revealed 100% identity with the strain from the first patient (2014) in Japan. 相似文献
42.
Takahiro Kametani Yuichiro Otani Toshikazu Ohigashi Tadahiko Kubo Tomohiko Sakuda Daisuke Furuta Yayoiko Ito Yuya Shigenobu Masaki Kakimoto Akihiro Kawahara Yuka Kikuchi Tomoki Kobayashi Daisuke Miyamori Nobusuke Kishikawa Keishi Kanno Masanori Ito 《Internal medicine (Tokyo, Japan)》2021,60(8):1311
We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenomegaly, and pulmonary interstitial changes. Treatment with prednisolone was successful. Because sarcoma is a rare disease, this case is valuable for showing clinicians that G-CSF preparations could cause aortitis regardless of the patient''s underlying diseases or therapeutic pharmacological backgrounds. 相似文献
43.
Kosuke Tanaka Akiko Sasaki Hideto Egashira Shinichi Teshima Karen Kimura Takashi Nishino Tomohiko Tazawa Junichi Tasaki Chikamasa Ichita Sakue Masuda Kazuya Koizumi Makoto Kako 《Internal medicine (Tokyo, Japan)》2021,60(7):999
We herein report the definitive diagnosis of rectovaginal endometriosis in two cases. Case 1 involved a 46-year-old woman with abdominal pain and hematochezia. The diagnosis after the first and second examinations using lower gastrointestinal (GI) endoscopy was unclear. Differential diagnoses included mucosa-associated lymphoid tissue and colorectal cancer. The third lower GI endoscopy with a targeted biopsy, performed during menstruation, confirmed rectovaginal endometriosis. Case 2 involved a 38-year-old woman with hematochezia. Lower GI endoscopy during menstruation revealed rectovaginal endometriosis. When rectovaginal or bowel endometriosis is suspected, lower GI endoscopy and a targeted biopsy during menstruation can prevent unnecessary surgery. 相似文献
44.
Taga K Imura S Hayashi A Kamakura K Hashimoto S Takasaki T Kurane I Uchida Y 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2002,76(9):738-746
To monitor the development of specific and cross-reactive antibody response in twenty Japanese volunteers after vaccination with live yellow fever vaccine. Serum samples were collected on various days after vaccination and examined for hemagglutination inhibition (HI) antibodies against yellow fever virus (YFV), Japanese encephalitis virus (JEV) and dengue virus (DV), neutralizing antibodies against YFV and JEV, and IgM antibodies against YFV. None of the volunteers had been previously immunized with this vaccine. Fifteen of 20 had pre-vaccinated with JEV 7 to 40 years before. Ten of the 20 had neutralizing antibodies against JEV before immunization. None of the 20 had detectable antibodies against YFV or DV before vaccination. On day 10th after the vaccination, neutralizing antibodies to YFV were detected in 6 of 19 volunteers and IgM antibodies against YFV were detected in 7 of 19. On day 14th, HI, neutralizing, and IgM antibodies against YFV were detected in all the tested sera. Neutralizing antibodies against JEV were developed in 2 volunteers and HI antibodies against JEV were increased in 3 of 6 volunteers respectively. On day 29th, cross-reactive HI antibodies for JEV and DV were detected in all the tested sera. The results indicate that YF vaccine induces YFV-specific antibodies in all the tested volunteers and that it also induces HI antibodies cross-reactive for JEV and DV. The YF vaccine has a strong immunogenicity because it is a live vaccine, and induces antibody against YFV predominantly. The international certificate of yellow fever vaccination becomes valid 10 days after vaccination. On day 14th after vaccination, we detected neutralizing antibodies against YFV from all tested volunteers, however, only 6 of 19 volunteers had detectable neutralizing antibody on the 10th day after vaccination. Therefore, the vaccine may not be perfectly effective on day 10th after the vaccination. 相似文献
45.
Yoshida Y Hirai M Yamada T Tsuji Y Kondo T Inden Y Akahoshi M Murakami Y Tsuda M Tsuboi N Hirayama H Okamoto M Ito T Saito H Toyama J 《Circulation》2000,101(6):624-630
46.
Miyajima E Shigemasa T Endo T Hishiki S Kawano Y 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2000,14(1):61-66
The cardiovascular and sympatholytic effects of combination therapy with guanabenz were examined in 26 patients (48 ± 13 years old [mean ± SD]) with stage 2 and 3 hypertension. Included in the study were patients under treatment with conventional antihypertensive drugs whose systolic and diastolic blood pressure was above 140 and 90 mmHg, respectively. Blood pressure, heart rate, and sympathetic parameters such as plasma concentration of norepinephrine and muscle sympathetic nerve activity at rest as well as during ambulatory conditions, 24-hour urinary excretion of norepinephrine, and low frequency (LF: 0.04–0.15 Hz)/high frequency (HF: 0.15–0.4 Hz) power ratio as a marker of cardiac sympathetic activity during 24 hours were examined before and after guanabenz (4–8 mg/d) combination therapy with first-line antihypertensive drugs such as diuretics. Left ventricular mass index (LVMI) was also calculated by conventional echocardiography. After 32 weeks of guanabenz combination therapy, systolic and diastolic blood pressure, heart rate, plasma and urinary excretion of norepinephrine, muscle sympathetic nerve activity, and LF/HF power ratio were significantly decreased, while neither LF nor HF power was changed. LVMI was also significantly decreased (270 ± 81 vs. 236 ± 83 g/m2, p < 0.005). These results indicate that guanabenz combination therapy inhibits sympathetic nerve activity under resting conditions as well as during ambulatory conditions and may accelerate regression of left ventricular hypertrophy in patients with moderate to severe hypertension. 相似文献
47.
Kurisu S Inoue I Kawagoe T Ishihara M Shimatani Y Mitsuba N Hata T Nakama Y Kisaka T Kijima Y 《Internal medicine (Tokyo, Japan)》2004,43(12):1157-1161
A 28-year-old man was admitted because of chest pain. Emergency coronary angiography showed a massive thrombus in the proximal segment and another occlusive thrombus in the distal segment of the left anterior descending artery. He was treated with thrombolytic therapy. Repeat coronary angiography showed disappearance of the thrombi in the proximal and distal segments and obvious myocardial bridging in the mid segment. Intravascular ultrasound revealed an atherosclerotic plaque in the segment immediately proximal to the myocardial bridging, but did not reveal any plaque within or distal to the site. He was discharged 12 days later. 相似文献
48.
Shimatani T Inoue M Harada N Horikawa Y Nakamura M Tazuma S 《Digestive diseases and sciences》2004,49(5):787-794
In the pathogenesis of gastroesophageal reflux disease (GERD), gastric acid is considered to be one of the most important factors, but little is known about the degree of gastric acid secretion in GERD patients. In this study, we evaluated it in GERD patients and control subjects by 24-h intragastric pH, and serological and histological investigations, in relation to Helicobacter pylori (H. pylori) status. In H. pylori-negative GERD patients gastric acid secretion was similar to that in H. pylori-negative control subjects. In H. pylori-positive GERD patients, in particular, mild GERD patients, it decreased significantly compared to that in H. pylori-negative control subjects, but the degree of decrease was smaller than in H. pylori-positive control subjects. Results of serological and histological evaluation were supportive. In conclusion, in some GERD patients, gastric acid secretion was significantly decreased. Increased or maintained gastric acid secretion was not essential in the pathogenesis of mild GERD. 相似文献
49.
Maeda T Yamada H Akao N Iga M Endo T Koibuchi T Nakamura T Odawara T Iwamoto A Fujii T 《Internal medicine (Tokyo, Japan)》2008,47(5):449-452
This report describes a case of hepatic phase Fasciola hepatica infection presenting huge and multilocular lesions. The unique radiological findings mimicked hydatid diseases and also cystic liver neoplasm. Fascioliasis should be included in the differential diagnosis for cystic liver diseases. 相似文献
50.
Comparative genomic hybridization analysis for pancreatic cancer specimens obtained by endoscopic ultrasonography-guided fine-needle aspiration 总被引:1,自引:0,他引:1
Kitoh H Ryozawa S Harada T Kondoh S Furuya T Kawauchi S Oga A Okita K Sasaki K 《Journal of gastroenterology》2005,40(5):511-517
Background Comparative genomic hybridization (CGH) analysis of pancreatic cancer has been done exclusively for surgical and autopsy specimens, because of the difficulty of tissue sampling without surgery. To overcome this difficulty, we applied CGH technology to cells obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).Methods In the present study, we performed EUS-FNA for 17 patients with pancreatic cancer before surgery. Tumor cells were selected by microdissection. DNA was extracted from the cells and amplified by degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR). Then CGH was carried out.Results In the 15 patients with tubular adenocarcinoma, the most common loci of gains (including amplification) were 5p, 8q, and 20q (60% of the patients); and 1q, 7p, and 12p (27%). The most frequent losses were 17p (73%); 9p, 18q, and 19p (47%); and 8p (33%). These findings were similar to our previously reported data. Both of the patients with acinar cell carcinoma showed gains of 2q and 5p, and losses of 1p, 9p, 9q, 11p, 11q, 14q, 17p, 17q, and 18q.Conclusions The results of this study suggest that comprehensive genetic analysis is possible for EUS-FNA biopsy specimens, with a combination of microdissection and DOP-PCR. This analytical strategy will enable us to evaluate the biological characteristics of pancreatic cancer before treatment. 相似文献