全文获取类型
收费全文 | 42714篇 |
免费 | 2052篇 |
国内免费 | 190篇 |
专业分类
耳鼻咽喉 | 691篇 |
儿科学 | 801篇 |
妇产科学 | 783篇 |
基础医学 | 5545篇 |
口腔科学 | 1256篇 |
临床医学 | 2968篇 |
内科学 | 10039篇 |
皮肤病学 | 569篇 |
神经病学 | 3437篇 |
特种医学 | 1499篇 |
外科学 | 7472篇 |
综合类 | 189篇 |
一般理论 | 2篇 |
预防医学 | 1522篇 |
眼科学 | 734篇 |
药学 | 3548篇 |
中国医学 | 80篇 |
肿瘤学 | 3821篇 |
出版年
2022年 | 363篇 |
2021年 | 768篇 |
2020年 | 376篇 |
2019年 | 551篇 |
2018年 | 657篇 |
2017年 | 509篇 |
2016年 | 608篇 |
2015年 | 678篇 |
2014年 | 878篇 |
2013年 | 1142篇 |
2012年 | 1818篇 |
2011年 | 1967篇 |
2010年 | 1119篇 |
2009年 | 977篇 |
2008年 | 1831篇 |
2007年 | 2040篇 |
2006年 | 1951篇 |
2005年 | 1914篇 |
2004年 | 1879篇 |
2003年 | 1884篇 |
2002年 | 1821篇 |
2001年 | 1627篇 |
2000年 | 1784篇 |
1999年 | 1513篇 |
1998年 | 500篇 |
1997年 | 395篇 |
1996年 | 372篇 |
1995年 | 317篇 |
1994年 | 294篇 |
1993年 | 260篇 |
1992年 | 1109篇 |
1991年 | 924篇 |
1990年 | 901篇 |
1989年 | 947篇 |
1988年 | 832篇 |
1987年 | 833篇 |
1986年 | 782篇 |
1985年 | 771篇 |
1984年 | 528篇 |
1983年 | 425篇 |
1982年 | 220篇 |
1979年 | 483篇 |
1978年 | 275篇 |
1977年 | 253篇 |
1975年 | 207篇 |
1974年 | 224篇 |
1972年 | 205篇 |
1971年 | 230篇 |
1969年 | 230篇 |
1968年 | 216篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
992.
Quantitative evaluation of the pulmonary microdistribution of TiO2 nanoparticles using X‐ray fluorescence microscopy after intratracheal administration with a microsprayer in rats
下载免费PDF全文
![点击此处可从《Journal of applied toxicology : JAT》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Guihua Zhang Naohide Shinohara Hirokazu Kano Hideki Senoh Masaaki Suzuki Takeshi Sasaki Shoji Fukushima Masashi Gamo 《Journal of applied toxicology : JAT》2015,35(6):623-630
The unevenness of pulmonary nanoparticle (NP) distribution, which hinders the establishment of an absolute dose–response relationship, has been described as one of the limitations of intratracheal administration techniques for toxicological assessment of inhaled NPs. Quantification of the NP microdistribution would facilitate the establishment of a concentration–response relationship in localized regions of the lung; however, such quantitative methods have not been reported. Here, we established a quantitative method for evaluating pulmonary TiO2 NP microdistribution in rats using X‐ray fluorescence microscopy. Ti intensity in lung sections from rats intratracheally administered 10 mg kg–1 TiO2 NPs with a microsprayer was measured using X‐ray fluorescence with a 100 µm beam size. Ti reference samples were prepared by dropping different concentrations of Ti solutions on glass slide or lung sections of untreated rat. Ti intensity increased linearly with Ti content in the reference samples on both substrates. The detection limit of TiO2 was estimated to be 6.3 ng mm–2. The reproducibility was confirmed for measurements done in the short‐ (2 weeks) and long‐term (6 months). The quantitative results of TiO2 NP microdistribution suggested that more TiO2 NPs were distributed in the right caudal and accessory lobes, which are located downstream of the administration direction of the NP suspension, and the lower portion of each lobe. The detection rates of TiO2 NPs were 16.6–25.0%, 5.19–15.6%, 28.6–39.2%, 21.4–38.7% and 10.6–23.2% for lung sections from the right cranial, middle, caudal, accessory and left lobes, respectively. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
993.
994.
Jain Divyanu Oda Tomoaki Kawai Kenta Horikoshi Yoshimasa Matsumoto Masako Narumi Megumi Kohmura-Kobayashi Yukiko Furuta-Isomura Naomi Yaguchi Chizuko Uchida Toshiyuki Suzuki Kazunao Kanayama Naohiro Itoh Hiroaki Tamura Naoaki 《Journal of thrombosis and thrombolysis》2022,53(1):208-212
Journal of Thrombosis and Thrombolysis - Pulmonary thromboembolism (PTE) is one of the leading causes of maternal mortality. We previously reported that possible contamination of amniotic fluid... 相似文献
995.
Shingo Nasu Kunimitsu Kawahara Yuki Han Norio Okamoto Yoshitaka Tamura Hidekazu Suzuki Takayuki Shiroyama Yumiko Samejima Tomohiro Kanai Yoshimi Noda Ayako Tanaka Naoko Morishita Kayo Ueda Shoji Hashimoto Tomonori Hirashima Takayuki Nagai 《Internal medicine (Tokyo, Japan)》2021,60(3):445
Miliary tuberculosis is a potentially lethal type of tuberculosis that results from the hematogenous dissemination of Mycobacterium tuberculosis bacilli. We herein describe the case of a 34-year-old man that presented with a one-month history of cough and fever, while his sputum smear results were negative. Chest computed tomography revealed bilateral centrilobular ground-glass opacification (GGO), suggestive of hypersensitivity pneumonitis; thus, bronchoscopy was performed. Cryobiopsy specimens revealed necrotic granulomas. A re-examination of sputum after bronchoscopy identified Mycobacterium tuberculosis, and miliary tuberculosis was diagnosed. A cryobiopsy might be useful for diagnosing miliary tuberculosis pathologically, particularly when miliary nodules may be masked by GGO. 相似文献
996.
Kayoko Kasuya Yusuke Kawamura Masahiro Kobayashi Junichi Shindoh Yuta Kobayashi Akira Kajiwara Soichi Iritani Shunichiro Fujiyama Tetsuya Hosaka Satoshi Saitoh Hitomi Sezaki Norio Akuta Fumitaka Suzuki Yoshiyuki Suzuki Kenji Ikeda Yasuji Arase Yuichiro Eguchi Masaji Hashimoto Hiromitsu Kumada 《Internal medicine (Tokyo, Japan)》2021,60(3):345
Objective A survival benefit was demonstrated for ramucirumab (RAM) in patients with unresectable hepatocellular carcinoma (uHCC) and α-fetoprotein (AFP) concentrations ≥400 ng/mL who had previously received sorafenib (SOR). However, it is unclear whether RAM has a similar efficacy in patients with uHCC that progresses after lenvatinib (LEN) treatment. This study aimed to evaluate the early anti-tumor response to RAM as a second-line treatment for advanced uHCC after LEN treatment. Methods We retrospectively assessed the efficacy and safety of RAM at 6 weeks after initiation. The therapeutic effects were evaluated according to the Response Evaluation Criteria in Solid Tumors version 1.1. Patients We evaluated 7 patients with uHCC who received RAM as a second- or third-line treatment after LEN failure. Results The disease control rate (DCR) was 28.6% (2 of 7 patients). After the initiation of RAM, a rapid disease progression resulted in 1 patient death after 19 days. The median progression-free survival (PFS) was 41 days. There were no grade 3 or 4 treatment-related adverse events. At 6 weeks, there was no deterioration in the modified albumin-bilirubin (mALBI) grade. In patients with an imaging response of stable disease (SD), the rate of AFP production decreased from the baseline. Conclusion RAM may have a therapeutic potential for the suppression of uHCC progression in patients previously treated with LEN, as well as for maintaining the liver function during treatment. Evaluating the AFP trends may therefore be useful for predicting RAM effectiveness. 相似文献
997.
Mitsuyasu Terashima Hideaki Kaneda Yasuhiro Honda Tetsuro Shimura Atsuko Kodama Maoto Habara Takahiko Suzuki 《Journal of cardiology》2021,77(5):435-443
Both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) play a crucial role in elucidating the pathophysiology of coronary artery disease (CAD) with the goal to improve patient outcomes of medical and/or interventional CAD management. However, no single intravascular imaging technique has been proven to provide complete and detailed evaluation of all CAD lesions due to some limitations. Although sequential use of multiple modalities may sometimes be performed, there may be issues related to risk, time, and cost. To overcome these problems, several hybrids involving dual-probe combined IVUS-OCT catheters have been developed.The aim of this review article is to demonstrate some limitations of stand-alone imaging devices for evaluation of CAD, summarize the advances in hybrid IVUS-OCT imaging devices, discuss the technical challenges, and present the potential value in the clinical setting, especially in patients receiving medical or interventional CAD management. 相似文献
998.
Toshihiro Miyamoto Masaki Iino Yasuji Komorizono Toru Kiguchi Nobufusa Furukawa Maki Otsuka Shohei Sawada Yutaka Okamoto Kenji Yamauchi Toshitaka Muto Tomoaki Fujisaki Hisashi Tsurumi Kimitoshi Nakamura 《Internal medicine (Tokyo, Japan)》2021,60(5):699
Objective For patients with Gaucher disease (GD), a rare, inherited lysosomal storage disease, obtaining a definitive diagnosis is currently time-consuming and costly. A simplified screening method to measure the glucocerebrosidase (GBA) activity using dried blood spots (DBS) on filter paper has recently been developed. Using this newly developed screening method, we evaluated real-world GD screening in patients suspected of having GD. Methods This multicenter, cross-sectional, observational study with a diagnostic intervention component evaluated real-world screening in patients suspected of having GD based on their clinical symptoms and a platelet count <120,000/μL. The endpoint was the number of patients with low GBA activity determined using DBS. Results In 994 patients who underwent initial DBS screening, 77 had low GBA activity. The assay was not repeated in 1 patient who was diagnosed as having a high possibility of GD due to clinical symptoms, and a further 21 patients completed the study without undergoing the second assay. Of the remaining 55 patients who had 2 DBS assays performed, 11 had a low GBA activity in both assays. Overall, DBS screening identified 12 (1.2%) patients with a low GBA activity, a proportion consistent with prior screening studies. Conclusion These results suggest that the simplified DBS method was less burdensome to patients, was easily utilized by many physicians, and could be a useful first-tier screening assay for GD prior to initiating burdensome genetic testing. 相似文献
999.
1000.
Suzuki Yutaka Mori Toshiyuki Momose Hirokazu Matsuki Ryota Kogure Masaharu Abe Nobutsugu Isayama Hiroyuki Tazuma Susumu Tanaka Atsushi Takikawa Hajime Sakamoto Yoshihiro 《Journal of gastroenterology》2022,57(5):387-395
Journal of Gastroenterology - Predictive factors for intrahepatic cholangiocarcinoma in long-term follow-up of hepatolithiasis are unknown. We thus conducted a cohort study to investigate the... 相似文献