全文获取类型
收费全文 | 4065篇 |
免费 | 187篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 81篇 |
儿科学 | 46篇 |
妇产科学 | 16篇 |
基础医学 | 504篇 |
口腔科学 | 182篇 |
临床医学 | 226篇 |
内科学 | 1160篇 |
皮肤病学 | 24篇 |
神经病学 | 300篇 |
特种医学 | 235篇 |
外科学 | 673篇 |
综合类 | 16篇 |
预防医学 | 69篇 |
眼科学 | 26篇 |
药学 | 285篇 |
中国医学 | 6篇 |
肿瘤学 | 416篇 |
出版年
2023年 | 40篇 |
2022年 | 52篇 |
2021年 | 97篇 |
2020年 | 41篇 |
2019年 | 69篇 |
2018年 | 90篇 |
2017年 | 58篇 |
2016年 | 73篇 |
2015年 | 67篇 |
2014年 | 106篇 |
2013年 | 138篇 |
2012年 | 281篇 |
2011年 | 305篇 |
2010年 | 156篇 |
2009年 | 131篇 |
2008年 | 225篇 |
2007年 | 255篇 |
2006年 | 263篇 |
2005年 | 273篇 |
2004年 | 253篇 |
2003年 | 242篇 |
2002年 | 259篇 |
2001年 | 95篇 |
2000年 | 72篇 |
1999年 | 79篇 |
1998年 | 39篇 |
1997年 | 37篇 |
1996年 | 38篇 |
1995年 | 34篇 |
1994年 | 41篇 |
1993年 | 16篇 |
1992年 | 52篇 |
1991年 | 35篇 |
1990年 | 41篇 |
1989年 | 29篇 |
1988年 | 16篇 |
1987年 | 25篇 |
1986年 | 17篇 |
1985年 | 9篇 |
1984年 | 13篇 |
1983年 | 11篇 |
1982年 | 13篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 9篇 |
1977年 | 10篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1971年 | 5篇 |
排序方式: 共有4265条查询结果,搜索用时 0 毫秒
971.
Sunagawa T Kinjo F Gakiya I Hokama A Kugai Y Matayoshi R Yonamine Y Tomiyama R Saito A 《Internal medicine (Tokyo, Japan)》2004,43(5):397-399
Protein-losing gastroenteropathy (PLG) can occur as a manifestation of various diseases including autoimmune disorders, and optimal therapy of these underlying diseases may be the only effective remedy for PLG. In the present report, we describe a case of a 54-year-old woman with PLG associated with an autoimmune disease, presumably CREST syndrome. She failed to respond to steroid treatment. Subsequently, cyclosporine was initiated, which resulted in a rapid recovery. The patient was successfully treated with low-dose cyclosporine for five years. There has not been, to our knowledge, any report of PLG successfully treated with cyclosporine. Cyclosporine therapy may be effective not only in inducing but also in maintaining complete remission in patients with autoimmune-associated PLG, especially refractory or intolerable to steroids and/or immunosuppressive therapies. 相似文献
972.
Yasuyuki Akine Nobuhiko Tokita Koichi Tokuuye Michinao Satoh Yoshinobu Fukumori Hiroyuki Tokumitsu Ryuichi Kanamori Tooru Kobayashi Keiji Kanda 《Journal of cancer research and clinical oncology》1992,119(2):71-73
Summary Gadolinium-containing microcapsules were evaluated as an agent for gadolinium neutron-capture therapy. Mice were inoculated intraperitoneally with 107 Ehrlich ascites tumor cells and gadolinium microcapsules and exposed to thermal neutrons for 12 min (approximately 1.86×1012 neutrons cm–2). Significantly more mice given gadolinium microcapsules than those given placebo microcapsules or control survived for 60 days and considerably longer (P<0.0001), indicating that gadolinium neutron-capture reactions effectively suppressed the growth of ascites tumor cells in mice. The results suggest that these microcapsules are an effective gadolinium carrier for neutron-capture therapy.Abbreviation MG
meglumine gadopentetate 相似文献
973.
Yoshinobu Onuma MD Shuzou Tanimoto MD Peter Ruygrok MD Jörg Neuzner MD Jan J. Piek MD PhD Ashok Seth MD Joachim J. Schofer MD Gert Richardt MD Marcus Wiemer MD Didier Carrié MD Leif Thuesen MD Cecile Dorange MSc Karine Miquel‐Hebert PhD Susan Veldhof RN Patrick W. Serruys MD PhD 《Catheterization and cardiovascular interventions》2010,76(5):634-642
Background : Little is known about the impact of treatment with drug‐eluting stents (DES) on calcified coronary lesions. This analysis sought to assess the safety and efficacy of the XIENCE V everolimus‐eluting stent (EES) in patients with calcified or noncalcified culprit lesions. Methods : The study population consisted of 212 patients with 247 lesions, who were treated with EES alone. Target lesions were angiographically classified as none/mild, moderate, or severe grades of calcification. The population was divided into two groups: those with at least one target lesion moderately or severely calcified (the calcified group: 68 patients with 75 calcified lesions) and those with all target lesions having mild or no calcification (the noncalcified group: 144 patients). Six‐month and 2‐year angiographic follow‐up and clinical follow‐up up to 3 years were completed. Results : The baseline characteristics were not significantly different between both groups. When compared with the noncalcified group, the calcified group had significantly higher rates of 6‐month in‐stent angiographic binary restenosis (ABR, 4.3% vs. 0%, P = 0.03) and ischemia‐driven target lesion revascularization (ID‐TLR, 5.9% vs. 0%, P = 0.01), resulting in numerically higher major cardiac adverse events (MACE, 5.9% vs. 1.4%, P = 0.09). At 2 years, when compared with the noncalcified group, the calcified group presented higher in‐stent ABR (7.4% vs. 0%, P = 0.08) and ID‐TLR (7.8% vs. 1.5%, P = 0.03), resulting in numerically higher MACE (10.9% vs. 4.4%, P = 0.12). At 3 years, ID‐TLR tended to be higher in the calcified group than in the noncalcified group (8.6% vs. 2.4%, P = 0.11), resulting in numerically higher MACE (12.1% vs. 4.7%, P = 0.12). Conclusions: The MACE rates in patients treated with EES for calcified lesions were higher than in those for noncalcified lesions, but remained lower than the results of previously reported stent studies. EES implantation in patients with calcified culprit lesions was safe and associated with favorable reduction of restenosis and repeat revascularization. © 2010 Wiley‐Liss, Inc. 相似文献
974.
Saiko Kurosawa Takuhiro Yamaguchi Shuichi Miyawaki Naoyuki Uchida Toru Sakura Heiwa Kanamori Kensuke Usuki Takuya Yamashita Yasushi Okoshi Hirohiko Shibayama Hirohisa Nakamae Momoko Mawatari Kazuo Hatanaka Kazutaka Sunami Manabu Shimoyama Naohito Fujishima Yoshinobu Maeda Ikuo Miura Yoichi Takaue Takahiro Fukuda 《Haematologica》2010,95(11):1857-1864
Background
Patients with acute myeloid leukemia who are treated with conventional chemotherapy still have a substantial risk of relapse; the prognostic factors and optimal treatments after relapse have not been fully established. We, therefore, retrospectively analyzed data from patients with acute myeloid leukemia who had achieved first complete remission to assess their prognosis after first relapse.Design and Methods
Clinical data were collected from 70 institutions across the country on adult patients who were diagnosed with acute myeloid leukemia and who had achieved a first complete remission after one or two courses of induction chemotherapy.Results
Among the 1,535 patients who were treated with chemotherapy alone, 1,015 relapsed. Half of them subsequently achieved a second complete remission. The overall survival was 30% at 3 years after relapse. Multivariate analysis showed that achievement of second complete remission, salvage allogeneic hematopoietic cell transplantation, and a relapse-free interval of 1 year or longer were independent prognostic factors. The outcome after allogeneic transplantation in second complete remission was comparable to that after transplantation in first complete remission. Patients with acute myeloid leukemia and cytogenetic risk factors other than inv(16) or t(8;21) had a significantly worse outcome when they did not undergo salvage transplantation even when they achieved second complete remission.Conclusions
We found that both the achievement of second complete remission and the application of salvage transplantation were crucial for improving the prognosis of patients with acute myeloid leukemia in first relapse. Our results indicate that the optimal treatment strategy after first relapse may differ according to the cytogenetic risk. 相似文献975.
976.
Ito T Sugino K Satoh D Muramatsu Y Sano G Sato K Sakaguchi S Isobe K Sakamoto S Takai Y Hata Y Shibuya K Uekusa T Kurosaki A Homma S 《Internal medicine (Tokyo, Japan)》2010,49(23):2605-2608
Bird fancier's lung (BFL) is one of the most common types of hypersensitivity pneumonitis. We report a rare case of acute-on-chronic bird fancier's lung that developed in a pigeon breeder and presented subpleural curvilinear shadow and ground glass opacity on high-resolution computed tomography (HRCT) of the chest. The results of surgical lung biopsy showed mainly intraalveolar organization and alveolitis in addition to the pattern of usual interstitial pneumonia with centrilobular fibrosis. Examination of bronchoalveolar lavage (BAL) fluid revealed an increase in lymphocytes. The results of immunoglobulin (Ig) G and IgA antibodies against pigeon dropping extracts were positive in sera and BAL fluid. Consequently, the patient was diagnosed as having BFL. Avoidance of pigeons and corticosteroid therapy led to rapid improvement. 相似文献
977.
978.
979.
Yamauchi T Adachi S Yasuda I Nakashima M Kawaguchi J Yoshioka T Hirose Y Kozawa O Moriwaki H 《International journal of oncology》2011,39(6):1375-1380
Pancreatic cancer is a highly lethal disease and gemcitabine is considered to be the standard of care for the treatment of advanced pancreatic cancer. However, the outcome of the patients treated with gemcitabine is still unstatisfactory and further development of new treatments is required. We recently found that short wavelength ultra-violet (UV-C) suppresses cell proliferation with downregulation of epidermal growth factor receptor (EGFR) in human pancreatic cancer cells, but not in normal pancreatic epithelial (PE) cells. In this study, we investigated the effect of UV-C on apoptosis in several cell lines derived from the pancreas. UV-C induced poly(ADP-ribose) polymerase (PARP) cleavage, which is a marker of cells undergoing apoptosis, in Panc1, MiaPaca2, KP3 and BxPC3 pancreatic cancer cells, but not in PE cells. We also observed similar effects in Hoechst 33258 staining, which shows DNA fragmentation. While p53, a tumor suppressor protein, plays a critical role in UV-C-induced cell damage, we did not observe the correlation between the sensitivity to UV-C and p53 status. Thapsigargin, an agent that promotes endoplasmic reticulum (ER) stress by depletion of lumenal calcium stores, as well as cis-diamineplatinum (II) dichloride, a classical anti-cancer drug that causes DNA damage, induced PARP cleavage even in PE cells. Moreover, UV-C-induced apoptosis in Panc1 and KP3 cells was associated with the release of cytochrome c, indicating that it was mediated via mitochondrial pathway. Taken together, UV-C has a potent anti-cancer effect on pancreatic cancer cells without adverse effect on normal cells and it could be useful for the treatment of human pancreatic cancers. 相似文献
980.
Cristianne Tomiyama Aluizio B Carvalho Andrea Higa Vanda Jorgetti Sérgio A Draibe Maria Eugênia F Canziani 《Journal of bone and mineral research》2010,25(3):499-504
Vascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. In earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4–2299.3 AU). The most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone‐formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p = .009; odd ratio (OR) = 0.15; 95% confidence interval (CI) 0.036–0.619]. This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. In conclusion, our results provide evidence that low bone‐formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. © 2010 American Society for Bone and Mineral Research 相似文献