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71.
Monika Zdanyte Peter Martus Jeremy Nestele Alexander Bild Lars Mizera Andreas Glatthaar lvaro Petersen Uribe Frederic Emschermann JessicaKristin Henes Tobias Geisler Karin Müller Meinrad Gawaz Dominik Rath 《Clinical cardiology》2022,45(9):943
BackgroundCardiovascular risk factors and comorbidities are highly prevalent among COVID‐19 patients and are associated with worse outcomes.HypothesisWe therefore investigated if established cardiovascular risk assessment models could efficiently predict adverse outcomes in COVID‐19. Furthermore, we aimed to generate novel risk scores including various cardiovascular parameters for prediction of short‐ and midterm outcomes in COVID‐19.MethodsWe included 441 consecutive patients diagnosed with SARS‐CoV‐2 infection. Patients were followed‐up for 30 days after the hospital admission for all‐cause mortality (ACM), venous/arterial thromboembolism, and mechanical ventilation. We further followed up the patients for post‐COVID‐19 syndrome for 6 months and occurrence of myocarditis, heart failure, acute coronary syndrome (ACS), and rhythm events in a 12‐month follow‐up. Discrimination performance of DAPT, GRACE 2.0, PARIS‐CTE, PREDICT‐STABLE, CHA2‐DS2‐VASc, HAS‐BLED, PARIS‐MB, PRECISE‐DAPT scores for selected endpoints was evaluated by ROC‐analysis.ResultsOut of established risk assessment models, GRACE 2.0 score performed best in predicting combined endpoint and ACM. Risk assessment models including age, cardiovascular risk factors, echocardiographic parameters, and biomarkers, were generated and could successfully predict the combined endpoint, ACM, venous/arterial thromboembolism, need for mechanical ventilation, myocarditis, ACS, heart failure, and rhythm events. Prediction of post‐COVID‐19 syndrome was poor.ConclusionRisk assessment models including age, laboratory parameters, cardiovascular risk factors, and echocardiographic parameters showed good discrimination performance for adverse short‐ and midterm outcomes in COVID‐19 and outweighed discrimination performance of established cardiovascular risk assessment models. 相似文献
72.
73.
E. Rehn Külbs Körte Abderhalden Griesbach Christeller Heyn Lewin Tobler Finkenrath Preuss Hellwig H. Braun Schmitz Schiff Putter A. Laqueur Vaternahm Lentz Herzfeld Eckstein Edens Staehelin Zinn Deusch Weigert Emil Neisser von Jaschke Neisser Adler Sellheim Schrader Kuhn Dietrich Koch Meyer Simon Eisner Friedemann Tobias Goldstein Vogel Steiner 《Journal of molecular medicine (Berlin, Germany)》1923,2(28):1324-1332
Ohne Zusammenfassung 相似文献
74.
Müller Friedrich Martius Simon Fischer W. Rosenow Juliusberg Braun Schmitz Magnus-Alsleben Goldschmidt Fabian Friedberg Eckstein Fischer A. W. Weigert Oppenheimer Koenigsfeld Hayward Herzfeld Halberstädter Holthusen Dietrich Dietlen Peiper Dessecker Westenhöfer Flury Nick Schlesinger Tobias Loewy-Hattendorf Steiner Goldstein Naef Jahnel Henning Köllner Meesmann Preuss Igersheimer Esch Kobrak Sturmann Vogel 《Journal of molecular medicine (Berlin, Germany)》1922,1(20):1010-1021
Journal of Molecular Medicine - 相似文献
75.
Nathalie Rohmann Liasita Munthe Kristina Schlicht Corinna Geisler Tobias J. Demetrowitsch Corinna Bang Julia Jensen-Kroll Kathrin Türk Petra Bacher Andre Franke Karin Schwarz Dominik M. Schulte Matthias Laudes 《Nutrients》2022,14(11)
Background: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of allergies. Methods: Using cross-sectional data from the German FoCus cohort, n = 385 allergy cases, either hay fever (=type I allergy, n = 183) or contact allergy (=type IV allergy, n = 202) were compared to age- and sex-matched healthy control subjects (1:1 ratio, in total n = 770) regarding their metabolic phenotype, diet, physical activity, sleep, gut microbial composition, and serum metabolite profile using suitable BMI-adjusted models. Results: Obesity and metabolic alterations were found significantly more prevalent in subjects with allergies. In fact, this relation was more pronounced in contact allergy than hay fever. Subsequent BMI-adjusted analysis reveals particular importance of co-occurring hyperlipidaemia for both allergy types. For contact allergy, we revealed a strong association to the dietary intake of poly-unsaturated fatty acids, particularly α-linolenic acid, as well as the enrichment of the corresponding metabolic pathway. For hay fever, there were no major associations to the diet but to a lower physical activity level, shorter duration of sleep, and an altered gut microbial composition. Finally, genetic predisposition for hyperlipidaemia was associated to both contact allergy and hay fever. Conclusions: Reflected by higher allergy prevalence, our findings indicate an impaired immune response in obesity and hyperlipidaemia, which is differentially regulated in type I and type IV allergies by an unfavourable lifestyle constellation and subsequent microbial and metabolic dysfunctions. 相似文献
76.
Does my high blood pressure improve your survival? Overall and subgroup learning curves in health 下载免费PDF全文
Learning curves in health are of interest for a wide range of medical disciplines, healthcare providers, and policy makers. In this paper, we distinguish between three types of learning when identifying overall learning curves: economies of scale, learning from cumulative experience, and human capital depreciation. In addition, we approach the question of how treating more patients with specific characteristics predicts provider performance. To soften collinearity problems, we explore the use of least absolute shrinkage and selection operator regression as a variable selection method and Theil–Goldberger mixed estimation to augment the available information. We use data from the Belgian Transcatheter Aorta Valve Implantation (TAVI) registry, containing information on the first 860 TAVI procedures in Belgium. We find that treating an additional TAVI patient is associated with an increase in the probability of 2‐year survival by about 0.16%‐points. For adverse events like renal failure and stroke, we find that an extra day between procedures is associated with an increase in the probability for these events by 0.12%‐points and 0.07%‐points, respectively. Furthermore, we find evidence for positive learning effects from physicians' experience with defibrillation, treating patients with hypertension, and the use of certain types of replacement valves during the TAVI procedure. 相似文献
77.
Janina Trauth Thomas Discher Moritz Fritzenwanker Can Imirzalioglu Tobias Arnold Dagmar Steiner Elvira Richter Laura Crisponi Bodo Grimbacher Susanne Herold 《Emerging infectious diseases》2022,28(7):1506
Mycobacterium genavense infection, a rare nontuberculous mycobacteria infection, occurs in heavily immunocompromised patients (i.e., those with advanced HIV disease, genetic disorders, or acquired immunologic disorders and those undergoing immunosuppressive therapy). We report a case of disseminated M. genavense infection preceding Hodgkin lymphoma in a patient without obvious risk factors for this infection. 相似文献
78.
79.
Juliane Kager Jochen Schneider Sebastian Rasch Peter Herhaus Mareike Verbeek Carolin Mogler Albert Heim Gert Frsner Dieter Hoffmann Roland M. Schmid Tobias Lahmer 《Viruses》2022,14(7)
Human adenovirus (HAdV) can often lead to fulminant hepatitis in immunocompromised patients, mostly after reactivation of HAdV. Different risk factors, e.g., transplantation and chemotherapy, increase the risk of developing a HAdV hepatitis. We retrospectively analyzed three patients who showed the characteristics of a HAdV hepatitis observed in disseminated disease. In addition to PCR, diagnosis could be proven by pathology, CT scan, and markedly elevated transaminases. All patients had a hemato-oncologic underlying disease. Two had received a stem-cell transplant, and one was under chemotherapy including rituximab. Despite therapy with cidofovir, all patients died. As the incidence of HAdV hepatitis is low, diagnosis may be easily overlooked. No treatment approaches have yet been established. HAdV hepatitis should be considered as a differential diagnosis, especially when risk factors are present. To avoid dissemination, treatment should be initiated as soon as possible. 相似文献
80.
RhD表型阴性分子机制的研究 总被引:5,自引:2,他引:5
我们对76名中国汉族RhD阴性个体的RHD基因全长编码区进行序列分析,初步探讨中国人D阴性的分子背景,报道如下。 相似文献