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Afifi K. Bellanger G. Buyck P. J. Zuurbier S. M. Garcia-Esperon C. Barboza M. A. Costa P. Escudero I. Renard D. Lemmens R. Hinteregger N. Fazekas F. Jimenez-Conde J. Giralt-Steinhauer E. Hiltunen S. Arauz A. Pezzini A. Montaner J. Putaala J. Weimar C. Schlamann Marc Gattringer T. Tatlisumak T. Coutinho J. M. Demaerel P. Thijs V. 《Journal of neurology》2020,267(11):3299-3300
Journal of Neurology - The original version of this article unfortunately contained mistakes. The correct information is given below. 相似文献
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Judith L. Thijs Ian Strickland Carla A.F.M. Bruijnzeel-Koomen Stefan Nierkens Barbara Giovannone Edward F. Knol Eszter Csomor Bret R. Sellman Tomas Mustelin Matthew A. Sleeman Marjolein S. de Bruin-Weller Athula Herath Julia Drylewicz Richard D. May DirkJan Hijnen 《The Journal of allergy and clinical immunology》2018,141(4):1523-1526
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L Laval R Martin JN Natividad F Chain S Miquel C Desclée de Maredsous S Capronnier H Sokol EF Verdu JET van Hylckama Vlieg LG Bermúdez-Humarán T Smokvina P Langella 《Gut microbes》2015,6(1):1-9
Impaired gut barrier function has been reported in a wide range of diseases and syndromes and in some functional gastrointestinal disorders. In addition, there is increasing evidence that suggests the gut microbiota tightly regulates gut barrier function and recent studies demonstrate that probiotic bacteria can enhance barrier integrity. Here, we aimed to investigate the effects of Lactobacillus rhamnosus CNCM I-3690 on intestinal barrier function. In vitro results using a Caco-2 monolayer cells stimulated with TNF-α confirmed the anti-inflammatory nature of the strain CNCM I-3690 and pointed out a putative role for the protection of the epithelial function. Next, we tested the protective effects of L. rhamnosus CNCM I-3690 in a mouse model of increased colonic permeability. Most importantly, we compared its performance to that of the well-known beneficial human commensal bacterium Faecalibacterium prauznitzii A2-165. Increased colonic permeability was normalized by both strains to a similar degree. Modulation of apical tight junction proteins expression was then analyzed to decipher the mechanism underlying this effect. We showed that CNCM I-3690 partially restored the function of the intestinal barrier and increased the levels of tight junction proteins Occludin and E-cadherin. The results indicate L. rhamnosus CNCM I-3690 is as effective as the commensal anti-inflammatory bacterium F. prausnitzii to treat functional barrier abnormalities. 相似文献
47.
Recombinant human bactericidal/permeability-increasing protein (rBPI23) is a universal lipopolysaccharide-binding ligand. 下载免费PDF全文
B J Appelmelk Y Q An B G Thijs D M MacLaren J de Graaff 《Infection and immunity》1994,62(8):3564-3567
A recombinant 23-kDa protein (rBPI23) derived from human bactericidal/permeability-increasing protein (BPI) possesses potent endotoxin-neutralizing abilities in vitro and in vivo. Binding of rBPI23 to those endotoxins (lipopolysaccharides [LPSs]) encountered clinically would be a prerequisite for efficacy in decreasing mortality among patients suffering from gram-negative sepsis and shock, a disease state in which an etiological role for LPS has been implicated. rBPI23 binds well to lipid A (n = 7), to rough-mutant O-chain-deficient LPS (n = 18, Re to Ra chemotypes), to lipid A-core covalently linked to the O chain, to LPSs from clinically relevant serotypes (n = 100), and to bacterial cells (n = 88) of Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, the species most often implicated in clinical gram-negative sepsis and shock. Significant binding of rBPI23 to these antigens took place at rBPI23 concentrations of 1 to 500 ng/ml (median, 16 to 32 ng/ml). Binding did not involve 3-deoxy-D-manno-octulosonate of the inner core. Determining the exact epitope recognized by rBPI23 would require further studies with synthetic lipid A substructures. The demonstrated ability of rBPI23 to universally bind LPS provides a sound basis for further testing of its endotoxin-neutralizing abilities, including clinical trials. 相似文献
48.
M. Kloss T. M. Metso D. Leys T. Brandt Y. Samson V. Caso A. Pezzini M. Sessa S. Beretta S. Debette C. Grond‐Ginsbach A. J. Metso V. Thijs C. Lamy E. Medeiros J. J. Martin A. Bersano T. Tatlisumak E. Touzé P. A. Lyrer for the Cervical Artery Dissection Ischaemic Stroke Patients ‐Study Group 《European journal of neurology》2012,19(9):1199-1206
Objective: To examine whether thrombolysis for stroke attributable to cervical artery dissection (CeADStroke) affects outcome and major haemorrhage rates. Methods: We used a multicentre CeADStroke database to compare CeADStroke patients treated with and without thrombolysis. Main outcome measures were favourable 3‐month outcome (modified Rankin Scale 0–2) and ‘major haemorrhage’ [any intracranial haemorrhage (ICH) and major extracranial haemorrhage]. Adjusted odds ratios [OR (95% confidence intervals)] were calculated on the whole database and on propensity‐matched groups. Results: Among 616 CeADStroke patients, 68 (11.0%) received thrombolysis; which was used in 55 (81%) intravenously. Thrombolyzed patients had more severe strokes (median NIHSS score 16 vs. 3; P < 0.001) and more often occlusion of the dissected artery (66.2% vs. 39.4%; P < 0.001). After adjustment for stroke severity and vessel occlusion, the likelihood for favourable outcome did not differ between the treatment groups [ORadjusted 0.95 (95% CI 0.45–2.00)]. The propensity matching score model showed that the odds to recover favourably were virtually identical for 64 thrombolyzed and 64 non‐thrombolyzed‐matched CeADStroke patients [OR 1.00 (0.49–2.00)]. Haemorrhages occurred in 4 (5.9%) thrombolyzed patients, all being asymptomatic ICHs. In the non‐thrombolysis group, 3 (0.6%) patients had major haemorrhages [asymptomatic ICH (n = 2) and major extracranial haemorrhage (n = 1)]. Conclusion: As thrombolysis was neither independently associated with unfavourable outcome nor with an excess of symptomatic bleedings, our findings suggest thrombolysis should not be withheld in CeADStroke patients. However, the lack of any trend towards a benefit of thrombolysis may indicate the legitimacy to search for more efficient treatment options including mechanical revascularization strategies. 相似文献
49.
Robert J. Lamberts Sergio Laranjo Stiliyan N. Kalitzin Demetrios N. Velis Isabel Rocha Josemir W. Sander Roland D. Thijs 《Epilepsia》2013,54(3):523-529
Purpose: Postictal generalized EEG suppression (PGES) seems to be a pathophysiologic hallmark in ictal recordings of sudden unexpected death in epilepsy (SUDEP). It has recently been suggested that presence and duration of PGES might be a predictor of SUDEP risk. Little is known about the etiology of PGES. Methods: We conducted a retrospective case–control study in 50 people with convulsive seizures (CS) recorded on digital video–electroencephalography (EEG). One CS per individual was reviewed for presence and duration of PGES by two independent observers: Preictal and postictal heart rate (HR) (1 min before seizure onset and 1, 3, 5, 15, and 30 min after seizure end) and frequency domain measures of heart rate variability (HRV), including the ratio of low frequency (LF) versus high frequency (HF) power, were analyzed. The relationship between PGES and periictal autonomic changes was evaluated, as well as its association with several clinical variables. Key Findings: Thirty‐seven individuals (74%) exhibited PGES and 13 (26%) did not. CS resulted in a significant increase of periictal HR and the LF/HF ratio. PGES was associated with neither periictal HR (mean HR difference between PGES+ and PGES? seizures: ?2 beats per minute [bpm], 95% confidence interval [CI] ?10 to +6 bpm) nor HRV change. There was no association between the duration of PGES and periictal HR change. People with PGES were more likely to be asleep before seizure onset (odds ratio [OR] 4.7, 95% CI 1.2–18.3) and had a higher age of onset of epilepsy (median age 15 vs. 4 years). Significance: PGES was not associated with substantial changes in measures of cardiac autonomic instability but was more prevalent in CS arising from sleep. 相似文献
50.
Klaufus Leonie H. Fassaert Thijs J. L. de Wit Matty A. S. 《Social psychiatry and psychiatric epidemiology》2014,49(7):1139-1149
Social Psychiatry and Psychiatric Epidemiology - This study explored (in)equities between ethnic groups in the Netherlands regarding their access to health care for symptoms of common mental... 相似文献