全文获取类型
收费全文 | 4724篇 |
免费 | 206篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 80篇 |
儿科学 | 154篇 |
妇产科学 | 234篇 |
基础医学 | 371篇 |
口腔科学 | 218篇 |
临床医学 | 373篇 |
内科学 | 1107篇 |
皮肤病学 | 83篇 |
神经病学 | 246篇 |
特种医学 | 198篇 |
外科学 | 1018篇 |
综合类 | 75篇 |
预防医学 | 133篇 |
眼科学 | 106篇 |
药学 | 230篇 |
中国医学 | 9篇 |
肿瘤学 | 334篇 |
出版年
2024年 | 4篇 |
2023年 | 36篇 |
2022年 | 66篇 |
2021年 | 105篇 |
2020年 | 56篇 |
2019年 | 88篇 |
2018年 | 123篇 |
2017年 | 102篇 |
2016年 | 135篇 |
2015年 | 175篇 |
2014年 | 199篇 |
2013年 | 258篇 |
2012年 | 392篇 |
2011年 | 375篇 |
2010年 | 185篇 |
2009年 | 175篇 |
2008年 | 353篇 |
2007年 | 401篇 |
2006年 | 361篇 |
2005年 | 356篇 |
2004年 | 268篇 |
2003年 | 228篇 |
2002年 | 181篇 |
2001年 | 87篇 |
2000年 | 63篇 |
1999年 | 63篇 |
1998年 | 12篇 |
1997年 | 11篇 |
1996年 | 11篇 |
1995年 | 13篇 |
1994年 | 1篇 |
1993年 | 7篇 |
1992年 | 17篇 |
1991年 | 18篇 |
1990年 | 13篇 |
1989年 | 10篇 |
1988年 | 7篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1939年 | 1篇 |
1934年 | 1篇 |
1927年 | 1篇 |
排序方式: 共有4969条查询结果,搜索用时 15 毫秒
41.
I Sahin R Serter F Karakurt B Demirbas C Culha C Taskapan F Kosar Y Aral 《Gynecological endocrinology》2004,19(3):115-124
In addition to the reproductive consequences, polycystic ovary syndrome (PCOS) is characterized by a metabolic disorder in which hyperinsulinemia and insulin resistance are central features. The effects and possible benefits from insulin-sensitizing drugs are not well known, especially in non-obese women with PCOS. This study was designed to evaluate the effects of metformin and flutamide on metabolic parameters and insulin resistance in non-obese women with PCOS. Thirty non-obese women newly diagnosed with PCOS and 15 age- and weight-matched healthy volunteers as controls were included in the study. Patients were assigned randomly to receive flutamide 250 mg daily or metformin 850 mg three times daily. Glucose, insulin, insulin resistance, androgen levels and glucose and insulin responses to an oral glucose tolerance tests (OGTT) were assessed before and after a 4-week therapy period. A positive correlation was found between body mass index and insulin level in patients with PCOS and controls. Follicle stimulating hormone, luteinizing hormone, free testosterone and dehydroepiandrosterone sulfate levels decreased significantly, but insulin resistance levels were not changed after flutamide therapy. Body weight, free testosterone, insulin and insulin resistance levels decreased significantly after metformin therapy. In conclusion, metformin treatment improved insulin sensitivity and decreased androgen levels, and flutamide decreased androgen levels but failed to improve insulin sensitivity in the non-obese women with PCOS. 相似文献
42.
Aman U Buzdar Nuhad K Ibrahim Deborah Francis Daniel J Booser Eva S Thomas Richard L Theriault Lajos Pusztai Marjorie C Green Banu K Arun Sharon H Giordano Massimo Cristofanilli Debra K Frye Terry L Smith Kelly K Hunt Sonja E Singletary Aysegul A Sahin Michael S Ewer Thomas A Buchholz Donald Berry Gabriel N Hortobagyi 《Journal of clinical oncology》2005,23(16):3676-3685
PURPOSE: The objective of this study was to determine whether the addition of trastuzumab to chemotherapy in the neoadjuvant setting could increase pathologic complete response (pCR) rate in patients with human epidermal growth factor receptor 2 (HER2) -positive disease. PATIENTS AND METHODS: Forty-two patients with HER2-positive disease with operable breast cancer were randomly assigned to either four cycles of paclitaxel followed by four cycles of fluorouracil, epirubicin, and cyclophosphamide or to the same chemotherapy with simultaneous weekly trastuzumab for 24 weeks. The primary objective was to demonstrate a 20% improvement in pCR (assumed 21% to 41%) with the addition of trastuzumab to chemotherapy. The planned sample size was 164 patients. RESULTS: Prognostic factors were similar in the two groups. After 34 patients had completed therapy, the trial's Data Monitoring Committee stopped the trial because of superiority of trastuzumab plus chemotherapy. pCR rates were 25% and 66.7% for chemotherapy (n = 16) and trastuzumab plus chemotherapy (n = 18), respectively (P = .02). The decision was based on the calculation that, if study continued to 164 patients, there was a 95% probability that trastuzumab plus chemotherapy would be superior. Of the 42 randomized patients, 26% in the chemotherapy arm achieved pCR compared with 65.2% in the trastuzumab plus chemotherapy arm (P = .016). The safety of this approach is not established, although no clinical congestive heart failure was observed. A more than 10% decrease in the cardiac ejection fraction was observed in five and seven patients in the chemotherapy and trastuzumab plus chemotherapy arms, respectively. CONCLUSION: Despite the small sample size, these data indicate that adding trastuzumab to chemotherapy, as used in this trial, significantly increased pCR without clinical congestive heart failure. 相似文献
43.
44.
45.
Incremental value of live/real time three‐dimensional transesophageal echocardiography over the two‐dimensional technique in the assessment of a tuberculoma involving the left atrium and appendage 下载免费PDF全文
Tuğba Kemaloğlu Öz M.D. Mahmoud Elsayed M.B.B.Ch Navin C. Nanda M.D. Koray Kalenderoğlu M.D. Şükrü Akyüz M.D. Işıl Atasoy M.D. Altuğ Ösken M.D. Tolga Onuk M.D. Mehmet Eren M.D. 《Echocardiography (Mount Kisco, N.Y.)》2016,33(9):1409-1412
Intracardiac tuberculomas are extremely rare, and cardiac involvement in tuberculosis accounts for only 0.5% of extrapulmonary tuberculosis. We report for the first time incremental value of live/real time three‐dimensional transesophageal echocardiography over two‐dimensional transesophageal echocardiography in the assessment of a tuberculoma involving the left atrium and left atrial appendage. 相似文献
46.
Renal complications of lipodystrophy: A closer look at the natural history of kidney disease 下载免费PDF全文
Baris Akinci Sadiye Mehtat Unlu Ali Celik Ilgin Yildirim Simsir Sait Sen Banu Nur Fatma Ela Keskin Basak Ozgen Saydam Nilufer Kutbay Ozdemir Banu Sarer Yurekli Bekir Ugur Ergur Melda Sonmez Tahir Atik Atakan Arslan Tevfik Demir Canan Altay Ulku Aybuke Tunc Tugba Arkan Ramazan Gen Erdal Eren Gulcin Akinci Aslihan Arasli Yilmaz Habib Bilen Samim Ozen Aygul Celtik Senay Savas Erdeve Semra Cetinkaya Huseyin Onay Sulen Sarioglu Elif Arioglu Oral 《Clinical endocrinology》2018,89(1):65-75
47.
Reliability of Charcot’s triad has long been questioned. Tokyo Guidelines committee published Tokyo Guidelines in 2007 and 2013. The aim of this study was to retrospectively examine the patients who had been treated with the diagnosis of acute cholangitis and evaluate 2007–2013 Tokyo criteria and Charcot’s triad. The files of the patients with acute cholangitis in a referral center were examined retrospectively. All patients were classified and evaluated according to 2007 and 2013 Tokyo criteria and Charcot’s triad; and results were compared. It was detected that 51.7 % of patients who did not meet Charcot’s triad were in definitive diagnosis group of both Tokyo criteria. Kappa value was calculated as 0.404 in the analysis of consistency between two Tokyo criteria. Two patients who had features sufficient to objectively make the diagnosis of acute cholangitis failed to meet the Tokyo criteria 2007 or 2013. Charcot’s triad is not sensitive and specific enough in the diagnosis of acute cholangitis. Revision of Tokyo 2007 criteria caused a change in the diagnostic status of 15 % of the patients. It is remarkable that kappa value can hardly be considered as a sign of moderate agreement between two Tokyo guidelines. Tokyo criteria should be supported and updated. 相似文献
48.
Hulda R Ozakpinar Ali T Tellioglu Tolga Eryilmaz Mustafa Durgun Emre Inozu Fatih Oktem 《International wound journal》2013,10(6):661-665
Extensive volar injuries are common and devastating because of the long‐term adhesion potency. The gliding effect of the adipose tissue is essential in preventing tendon adhesions after injury. In this study, we present the results of performing adipofascial flaps for the reconstruction of soft tissue defects following wrist trauma. The study included 15 patients. Adipofascial flaps were performed for immediate coverage of the tissue defect in 2 patients and for late adhesion‐related problems in 13 patients. Flap dimensions varied from 8 × 14 to 8 × 20 cm. All but one of the flaps and skin grafts survived uneventfully. None of the patients, whether immediate or late, required another operation to address further adhesion problems. Since adipofascial flaps provide a gliding surface, they are a good choice for immediate coverage of soft tissue defects in the wrist that are not suitable for skin grafting alone as well as for late adhesion‐related problems. 相似文献
49.
Gokcen Gonen MD Semra Ulusoy Kaymak MD Eylem Sahin Cankurtaran MD Ersin Hatice Karslioglu MD Elvan Ozalp MD Haldun Soygur MD PhD 《Journal of psychosocial oncology》2013,31(3):347-358
Suffering comes in many ways for patients confronting cancer. One of these is an unspecifiable fear about death, which is an existential issue. The aim of this study was to investigate the relationship between death anxiety and its correlates in cancer patients. Seventy cancer patients were assessed using SCID-I, Templer's Death Anxiety Scale, the Hospital Anxiety (A) and Depression (D) Scale, the Distress Thermometer, the Visual Analogue Scale for pain (VAS), the Global Assessment of Functioning, and Glock and Stark's Dimensions of Religious Commitment scales, and these assessments were compared between cancer patients with and without death anxiety. Multiple regression analysis was conducted after correlation analysis between death anxiety and sociodemographic and clinical variables. Axis I psychiatric diagnosis, pain scores, and negative believes about what will happen after death were found to be higher in patients having death anxiety than patients not having death anxiety. Also life expectancy was perceived as shortened in patients with death anxiety. Death anxiety was associated with anxiety, depressive symptoms, and beliefs about what will happen after death. In conclusion, death anxiety could not be regarded as a natural consequence of having cancer; it is associated with the unresolved psychological and physical distress. 相似文献
50.
Volkan Tugcu Nevzat Can Sener Selcuk Sahin Cuneyd Sevinc Mithat Eksi Abdullah Hizir Yavuzsan Ali Ihsan Tasci 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2016,20(4)
Methods:We retrospectively analyzed the patients who underwent RALRP for localized prostate cancer by a single surgeon in our clinic from January 1, 2009–February 1, 2016. Continence was defined as no leakage or use of a safety pad for minimal leakage. The main outcome measure was continence at postoperative week 1 and months 1, 6, and 12.Results:Between 2009 and 2016, 239 patients underwent RALRP for localized prostate disease. Seventy-four patients underwent a standard approach (group 1), 88 had posterior reconstruction (group 2), and 77 had posterior reconstruction with total anatomic restoration (group 3). After 1 week, 24.3% of the patients in group 1 (18/74), 31.8% in group 2 (28/88), and 45.8% in group 3 (33/72) were continent (P = .02). One month after the surgery, continence rates for groups 1, 2, and 3 were 56.7, 67, and 75%, respectively (0.065). After 6 and 12 months, continence rates for groups 1, 2, and 3 were 72.9 and 87.8%, 81.8 and 89.7%, and 84.7 and 91.6%, respectively (P = .178 and .7484).Conclusion:Anatomic restoration improves continence rates in the early period after RALRP. Even though other parameters were higher in the total restoration group, immediate continence (at 1 week) was significantly better. 相似文献