Women worried about their familial breast cancer risk--a study on genetic advice in general practice

AIMS: To ascertain whether women who consulted their GP because they perceived themselves as at increased risk of familial breast cancer were indeed at increased risk, and to evaluate potential strategies for assessing genetic risk of breast cancer in general practice. METHODS: Sixty-seven out of 81 women who had consulted their GP for advice about their possible increased risk of developing breast cancer due to breast cancer in the family were interviewed. Familial breast cancer risk was assessed by a clinical geneticist. This assessment was compared with two recent guidelines for referral for genetic counselling. RESULTS: More than half (52%; n = 35) the women had a relative risk of two and over for developing breast cancer, while another half of these 35 (25%; n = 17) had a relative risk of three and over. All the women (n = 17) with a relative risk of three and over were identified by means of the two current guidelines for referral for genetic counselling, while more than half of the women (61%; n = 11) with a relative risk between two and three were identified. CONCLUSIONS: More than half the women concerned about their familial risk of breast cancer are indeed at increased risk of breast cancer. Current guidelines correctly identify women at high risk. However, doubts about the health gain and feasibility of referral warrant caution, and need further investigation.      

Complex regional pain syndrome 1 – the Swiss cohort study

Background  

Little is known about the course of Complex Regional Pain Syndrome 1 and potential factors influencing the course of this disorder over time. The goal of this study is a) to set up a database with patients suffering from suspected CRPS 1 in an initial stadium, b) to perform investigations on epidemiology, diagnosis, prognosis, and socioeconomics within the database and c) to develop a prognostic risk assessment tool for patients with CRPS 1 taking into account symptomatology and specific therapies.     

Xeromammographic automatic exposure termination

A method of automatic exposure termination (AET) for xeromammography has been devised, significantly reducing the rate of repeat exposures due to poor choice of manual exposure factors. AET images are of good quality and are reliably produced. The concept of AET is based on the existence of an optimal transmitted exposure to the selenium plate, which is easily determined experimentally. In routine clinical xeromammography, a repeat rate of 20% was eliminated by the use of AET.     

Verzweigtkettig substituierte Trifluormethylpyrimidine

Trifluoromethylpyrimidines Carrying Branched Chain Substituents The reaction conditions used in the condensation of O-methylisourea sulfate (1a) with the β-diketones 2a–2c to produce the pyrimidine derivatives 3a–3c may also be applied to the β-diketones 2d–2g to synthesize the pyrimidine derivatives 3g, 3i, 3k, and 3m which carry a branched chain substituent in 4-position. The 2-(methylthio)pyrimidines 3d, 3e, 3f, 3h, 3j, 3l, and 3n arise from the reactions of S-methylisothiourea sulfate (1b) with 2a–2g. Reactions of 1a or 1b with 7,7-dimethyl-1,1,1,2,2,3,3-heptafluoro-4,6-octanedione (4) yield the addition products 5a and 5b.