全文获取类型
收费全文 | 2341篇 |
免费 | 86篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 60篇 |
妇产科学 | 7篇 |
基础医学 | 376篇 |
口腔科学 | 65篇 |
临床医学 | 173篇 |
内科学 | 603篇 |
皮肤病学 | 15篇 |
神经病学 | 204篇 |
特种医学 | 46篇 |
外科学 | 334篇 |
综合类 | 8篇 |
一般理论 | 1篇 |
预防医学 | 56篇 |
眼科学 | 118篇 |
药学 | 173篇 |
中国医学 | 13篇 |
肿瘤学 | 164篇 |
出版年
2022年 | 13篇 |
2021年 | 17篇 |
2020年 | 10篇 |
2019年 | 16篇 |
2018年 | 15篇 |
2017年 | 22篇 |
2016年 | 31篇 |
2015年 | 28篇 |
2014年 | 43篇 |
2013年 | 30篇 |
2012年 | 93篇 |
2011年 | 138篇 |
2010年 | 61篇 |
2009年 | 67篇 |
2008年 | 149篇 |
2007年 | 164篇 |
2006年 | 200篇 |
2005年 | 167篇 |
2004年 | 179篇 |
2003年 | 175篇 |
2002年 | 185篇 |
2001年 | 25篇 |
2000年 | 20篇 |
1999年 | 32篇 |
1998年 | 39篇 |
1997年 | 33篇 |
1996年 | 26篇 |
1995年 | 32篇 |
1994年 | 46篇 |
1993年 | 30篇 |
1992年 | 22篇 |
1991年 | 22篇 |
1990年 | 19篇 |
1989年 | 27篇 |
1988年 | 23篇 |
1987年 | 22篇 |
1986年 | 19篇 |
1985年 | 8篇 |
1984年 | 19篇 |
1983年 | 17篇 |
1982年 | 19篇 |
1981年 | 17篇 |
1980年 | 13篇 |
1979年 | 11篇 |
1978年 | 17篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1974年 | 6篇 |
1973年 | 7篇 |
排序方式: 共有2434条查询结果,搜索用时 27 毫秒
1.
2.
Shinhiro Takeda Kazuhiro Nakanishi Teruo Takano Gen Ishikawa Ryo Ogawa 《Journal of anesthesia》1997,11(2):83-87
Effective gas exchange can be maintained in animals without endotracheal intubation using external high-frequency oscillation
(EHFO). The aim of this study was to evaluate the effect of EHFO in patients with respiratory failure due to severe cardiogenic
pulmonary edema. Seven patients were ventilated with EHFO for 2h at 60 oscillations·min−1, with a cuiras pressure of 36 cmH2O (−26 to +10) and an inspiratory to expiratory ratio of 1:1, with EHFO. Blood gas values and hemodynamic parameters were
measured. Significant increases were noted in cardiac index (2.3±0.5 to 2.5±0.5 l·m−2;P<0.05), stroke volume index (24±7 to 28±8 ml·m−2;P<0.05), and arterial O2 pressure (Pao2) (70±4 to 95±23 mmHg;P<0.01) without a change in pulmonary artery wedge pressure at 1 h after EHFO. The respiratory rate decreased from 28±3 to
22 ±3 breaths·min−1 at 5 min after the termination of EHFO (P <0.01). Arterial CO2 pressure (Paco2) did not, however, decrease. Increased stroke volume without a change in pulmonary artery wedge pressure (preload) suggests
either improved inotropic function of the left ventricle or reduced left ventricular afterload with EHFO. The use of EHFO
may be effective not only for gas exchange but also for left ventricular function in patients with severe cardiogenic pulmonary
edema. 相似文献
3.
4.
A technique for reducing the morbidity and mortality of pancreatoduodenectomy by using an omental flap to protect the anastomoses and splanchnic vessels exposed during dissection is described herein. 相似文献
5.
Teruo Iwasaki Katsuhiro Nakagawa Motoaki Yasukawa Hiroyuki Shiono Teruaki Nagano Kunimitsu Kawahara 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(1):35-39
Ectopic cervical or cervico-mediastinal thymomas are very rare and most of them are asymptomatic, except for the presence
of a cervical mass. We present the case of a 71-year-old man with an ectopic cervico-mediastinal thymoma threatening superior
vena cava syndrome. He had a slight headache and presented with venous dilatation on the chest wall. A computed tomographic
scan and magnetic resonance, imaging of the chest demonstrated a mass extending from the right neck to the hilum, that indented
the trachea and compressed and displaced the brachiocephalic veins anteriorly. Under a right hemicollar incision and median
sternotomy, the mass was resected en bloc together with the thymus. The resected specimen was an encapsulated mass measuring 11×7×4 cm. The pathological diagnosis
was type AB, non-invasive thymoma, confirmed by 3-color flow, cytometry of tumor-derived lymphocytes. Flow cytometry using
biopsy material may contribute to the preoperative diagnosis of ectopic thymoma. 相似文献
6.
Kenji Yamao Atsushi Irisawa Hiroyuki Inoue Koji Matsuda Mitsuhiro Kida Shomei Ryozawa Yoshiki Hirooka Teruo Kozu 《Digestive endoscopy》2007,19(Z1):S180-S205
Standard imaging techniques using a curved linear array echoendocope are summarized to facilitate the attainment of expertise in endoscopic ultrasonography and endoscopic ultrasound‐guided fine needle aspiration, and to promote the widespread use of this diagnostic and therapeutic tool. Typical images of the mediastinal organs, the bilio‐pancreatic systems and neighboring organs by scanning from the esophagus, stomach, duodenal bulb, and descending portion of the duodenum, are shown in a sequential manner. The basic techniques of endoscopic ultrasound‐guided fine needle aspiration are also presented. 相似文献
7.
Toshiaki Tadai M.D. Hideko Kanai M.D Michihiko Nakamura M.D. Teruo Nakajima M.D. Mitsue Fujita M.D. Yoshihide Nakai M.D. 《Psychiatry and clinical neurosciences》1994,48(3):541-545
Abstract: The Self-Rating Body Image (SRBI) test was used to determine whether the patients with eating disorders such as anorexia nervosa or bulimia showed their body image disturbance or not. The SRBI was completed by 120 subjects who consisted of 30 low weight (LW) controls, 30 normal weight (NW) controls, 30 high weight (HW) controls, 18 anorexic patients (AN) and 12 bulimic patients (BN). The AN group had a significantly greater dissatisfaction with the scales of the body shape, visceral organ and face image of the SRBI than the weight-matched LW group. The BN group had a significantly greater dissatisfaction with the visceral organ image than the weight-matched NW group. However, no significant difference in the body shape and face images between the BN and NW groups was found. Our results suggest that the anorexic patients may disturb more parts of the body image than the bulimic patients though both the anorexic and bulimic patients showed the disturbance of body image. 相似文献
8.
Motoko Yanase Hideto Tanaka Teruo Nakayama 《European journal of applied physiology》1989,58(4):446-451
Summary In female rats, rectal temperature (T
re), tail vasomotor response, oxygen uptake
, and carbon dioxide production
were measured in proestrus and estrus stages during treadmill running at two different speeds at an ambient temperature (T
a) of 24° C. Experiments were performed at 2.00–6.00 a.m., when the difference inT
re was greatest between the two stages;T
re at rest in the estrus stage was 0.54° C higher than in the proestrus stage. In a mild warm environment, thresholdT
re for a rise in tail skin temperature (T
tail) was also higher in the estrus stage than in the proestrus stage. In contrast, no difference was seen in the thresholdT
re and steady stateT
re at the end of exercise between proestrus and estrus stages. These values were higher at the higher work intensity.
was also similar between the two stages, except in the second 5 min after the beginning of exercise, when
was greater andT
re rose more steeply in the proestrus stage. These data indicate that deep body temperature during exercise is regulated at a certain level depending on the work intensity and is not influenced by the estrus cycle.This study was supported in part by a Grant-in Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (Grant No. 62480114) 相似文献
9.
While tissue engineering has long been thought to possess enormous potential, conventional applications using biodegradable scaffolds have limited the field's progress, demonstrating a need for new methods. We have previously developed cell sheet engineering using temperature-responsive culture dishes in order to avoid traditional tissue engineering approaches, and their related shortcomings. Using temperature-responsive dishes, cultured cells can be harvested as intact sheets by simple temperature changes, thereby avoiding the use of proteolytic enzymes. Cell sheet engineering therefore allows for tissue regeneration by either direct transplantation of cell sheets to host tissues or the creation of three-dimensional structures via the layering of individual cell sheets. By avoiding the use of any additional materials such as carrier substrates or scaffolds, the complications associated with traditional tissue engineering approaches such as host inflammatory responses to implanted polymer materials, can be avoided. Cell sheet engineering thus presents several significant advantages and can overcome many of the problems that have previously restricted tissue engineering with biodegradable scaffolds. 相似文献
10.
Shirai Y Hashimoto M Kato R Kawamura YI Kirikae T Yano H Takashima J Kirihara Y Saito Y Fujino MA Dohi T 《Journal of clinical immunology》2004,24(1):42-52
Despite the huge number of colonized Gram-negative bacteria in the colon, the normal colon maintains its homeostasis without any excessive immune response. To investigate the potential mechanisms involved, human colonic lamina propria mononuclear cells (LPMCs) obtained from uninflamed mucosa were cultured with lipopolysaccharide (LPS) prepared from Bacteroides vulgatus (BV-LPS) or Bacteroides fragilis (BF-LPS), as representatives of indigenous flora, or pathogenic Salmonella minnesota (SM-LPS). Colonic LPMCs failed to produce inflammatory cytokines in response to any type of LPS. Colonic macrophages barely expressed mRNA for MD-2, an essential association molecule for LPS signaling via Toll-like receptor 4. Further, BV-LPS induced CD25 and Foxp3 expression in lymphocytes and CD4(+)CD25(+) cells expressed IL-10 mRNA. Thus, the low expression of functioning LPS receptor molecules and induction of IL-10-producing CD4(+)CD25(+) lymphocytes by indigenous LPS may play a central role in the maintenance of colonic immunological homeostasis. 相似文献