Teeth clenching can modify the muscle contraction strength of the lower or upper limbs: systematic review

Sport Sciences for Health - This systematic review aimed to investigate the evidence of the interaction between teeth clenching and stimulation on the muscles of the lower and upper limbs. PubMed,...     

Acute cholestatic hepatitis caused by amoxicillin/ clavulanate

Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used,especially for the treatment of respiratory and cutaneous infections.In general,it is a well-tolerated oral antibiotic.However,amoxicillin/clavulanate can cause adverse effects,mainly cutaneous,gastrointestinal,hepatic and hematologic,in some cases.Presented here is a case report of a 63-yearold male patient who developed cholestatic hepatitis after recent use of amoxicillin/clavulanate.After 6 wk of prolonged use of the drug,he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia(total bilirubin>300 mg/L).Diagnostic investigation was conducted by ultrasonography of the upper abdomen,serum tests for infection history,laboratory screening of autoimmune diseases,nuclear magnetic resonance(NMR)of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by ultrasound.The duration of disease was approximately 4 mo,with complete resolution of symptoms and laboratory changes at the end of that time period.Specific treatment was not instituted,only a combination of anti-emetic(metoclopramide)and cholestyramine for pruritus.     

Effect of Aloe vera. on Rat Pulp Tissue

Abstract

Aloe vera. L. (Aloeaceae) has been extensively studied for anti-inflammatory, antimicrobial, and cellular regeneration properties. This work evaluated in vivo. the effects of powder of freeze-dried Aloe vera. on rat pulp tissue. Pulp tissue was mechanically exposed to Aloe vera., and it was evaluated at 1 to 30 days after the procedure by histopathologic examination. A predominant acute-moderate inflammatory infiltrate was observed in the Aloe vera.–treated group 1 to 7 days after treatment. At 14 to 30 days, pulp tissue took a normal pattern when comparing Aloe vera. treatment with the Ca(OH)₂ treatment; it was found that both treatment groups stimulated reparative dentin and the formation of complete bridge. Strong superficial necrosis was detected exclusively for Ca(OH)₂. It seems evident that application of Aloe vera. in direct contact with the exposed pulp has acceptable biocompatibility and can lead to tertiary bridge formation.     

Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer

To assess the ingestion of folate and nutrients involved in the 1-carbon cycle in non-treated patients with colorectal adenocarcinoma in a reference center for oncology in southeastern Brazil. In total, 195 new cases with colorectal adenocarcinoma completed a clinical evaluation questionnaire and a Food Frequency Questionnaire (FFQ). Blood samples from 161 patients were drawn for the assessment of serum folate. A moderate correlation was found between serum concentrations of folate, folate intake and the dietary folate equivalent (DFE) of synthetic supplements. Mulatto or black male patients with a primary educational level had a higher intake of dietary folate. Of patients obtaining folate from the diet alone or from dietary supplements, 11.00% and 0.10%, respectively, had intake below the recommended level. Of the patients using dietary supplements, 35% to 50% showed high levels of folic acid intake. There was a prevalence of inadequacy for vitamins B2, B6 and B12, ranging from 12.10% to 20.18%, while 13.76% to 22.55% of patients were likely to have adequate choline intake. The considerable percentage of patients with folate intake above the recommended levels deserves attention because of the harmful effects that this nutrient may have in the presence of established neoplastic lesions.     

Phthalimido-thiazole as privileged scaffold: activity against immature and adult worms of Schistosoma mansoni

Parasitology Research - Phthalimide, 1,3-thiazole, and thiazolidinone cores are considered privileged scaffolds and represent an attractive starting point to design new bioactive compounds for...