全文获取类型
收费全文 | 14842篇 |
免费 | 774篇 |
国内免费 | 91篇 |
专业分类
耳鼻咽喉 | 230篇 |
儿科学 | 232篇 |
妇产科学 | 203篇 |
基础医学 | 1609篇 |
口腔科学 | 481篇 |
临床医学 | 1205篇 |
内科学 | 4139篇 |
皮肤病学 | 160篇 |
神经病学 | 941篇 |
特种医学 | 486篇 |
外科学 | 2576篇 |
综合类 | 58篇 |
一般理论 | 1篇 |
预防医学 | 454篇 |
眼科学 | 256篇 |
药学 | 861篇 |
中国医学 | 16篇 |
肿瘤学 | 1799篇 |
出版年
2023年 | 109篇 |
2022年 | 165篇 |
2021年 | 384篇 |
2020年 | 192篇 |
2019年 | 242篇 |
2018年 | 301篇 |
2017年 | 227篇 |
2016年 | 291篇 |
2015年 | 321篇 |
2014年 | 416篇 |
2013年 | 430篇 |
2012年 | 775篇 |
2011年 | 849篇 |
2010年 | 508篇 |
2009年 | 376篇 |
2008年 | 761篇 |
2007年 | 790篇 |
2006年 | 802篇 |
2005年 | 861篇 |
2004年 | 826篇 |
2003年 | 806篇 |
2002年 | 765篇 |
2001年 | 350篇 |
2000年 | 379篇 |
1999年 | 377篇 |
1998年 | 184篇 |
1997年 | 129篇 |
1996年 | 156篇 |
1995年 | 132篇 |
1994年 | 113篇 |
1993年 | 127篇 |
1992年 | 286篇 |
1991年 | 253篇 |
1990年 | 193篇 |
1989年 | 189篇 |
1988年 | 184篇 |
1987年 | 189篇 |
1986年 | 163篇 |
1985年 | 151篇 |
1984年 | 115篇 |
1983年 | 83篇 |
1982年 | 60篇 |
1981年 | 57篇 |
1979年 | 63篇 |
1978年 | 53篇 |
1975年 | 51篇 |
1974年 | 54篇 |
1971年 | 42篇 |
1969年 | 47篇 |
1968年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
51.
A Sakamoto T Miyazaki K Komori K Taketomi K Tobinaga M Kishikawa S Kohno K Hara 《Nihon Kyōbu Shikkan Gakkai zasshi》1992,30(8):1532-1536
A 14-year-old girl was admitted because of cough, chest pain and hemosputum. Chest roentgenogram on admission showed a pneumothorax and a cavitary lesion with niveau formation in the right lung and cystic lesions in the bilateral lung fields. After bed rest and intravenous administration of antibiotics for two weeks, the right lung inflated well and the niveau formation disappeared, and the patient was discharged. One week later, she was readmitted with sudden-onset severe dyspnea, caused by bilateral pneumothoraces. Emergency tube thoracostomy and wedge resection of the bullous lesion was performed. Macroscopically, multiple small cystic changes were seen on the surface of the right lung. Histological examination revealed nodular proliferations of smooth muscle cells in the interstitium and vessel walls in the lung, which contained slit-like lymphatic channels. The diagnosis of pulmonary lymphangiomyomatosis was made. In this case, we could not measure receptors for estrogen and progesterone. Recently, hormonal therapy and oophorectomy have been reported as being useful. Tamoxifen (Norvadex) was therefore initiated, and the patient has remained well with slight dyspnea on exertion. There has been no recurrence of pneumothorax. Lymphangiomyomatosis is a rare disease of unknown etiology which occurs exclusively in women, mostly in those of reproductive age. We report a 14-year-old female patient with lymphangiomyomatosis associated with repeated pneumothorax, who had been under treatment for epilepsy. We believe this case to be of importance because of the long discussed relation between pulmonary lymphangiomyomatosis and tuberous sclerosis. 相似文献
52.
Yoshihide Nagasako Meang Bong Jin Hiroshi Miyazaki Masato Nakayama Tsuyoshi Shimamura Hiroyuki Furukawa Michiaki Matushita Satoru Todo 《Liver transplantation》2006,12(3):435-439
Thrombocytopenia is a frequent finding following living donor hepatectomy. It appears more pronounced in right graft donors than in left graft donors. This study analyzed postoperative thrombocytopenia in 20 living liver donors and examined the change of endogenous thrombopoietin (TPO) in its recovery. Platelet count, TPO level, fibrinogen degradation product (FDP), and D-Dimer were measured before surgery and on postoperative days (PODs) 1, 2, 3, 5, 7, and 14. Concurrently, liver and spleen volumes were calculated by computed tomography. Platelet count on POD 3 was significantly lower in right graft donors than in left graft donors (13.0 +/- 3.7 x 10(4)/microL vs. 16.8 +/- 4.0 x 10(4)/microL, P = 0.039) but recovered by POD 7 in all donors. Postoperative elevations of FDP and D-Dimer were significantly higher in right graft donors than in left graft donors. TPO level rose immediately after surgery, peaked on POD 5 in left graft donors and on POD 7 in right graft donors, and fell nearly to preoperative levels by POD 14. Postoperative TPO level per liver volume was significantly higher in right graft donors than in left graft donors. In conclusion, thrombocytopenia following living donor hepatectomy resolved within the first week regardless of graft type and was mainly associated with increasing consumption of circulating platelets, possibly due to intrahepatic and splenic congestion. With a reduced number of circulating platelets, TPO level rapidly increases. Also, with reduced consumption of platelets related to recovery from surgery, thrombocytopenia should resolve. As a consequence, TPO level would be expected to fall. 相似文献
53.
M Noguchi M Earashi H Kitagawa N Ohta M Thomas I Miyazaki Y Mizukami T Michigishi 《Journal of surgical oncology》1992,49(3):140-146
The surgical management in papillary thyroid cancer has been highly controversial. In the Department of Surgery (II), Kanazawa University Hospital, the surgical management especially for cervical lymph node metastases has changed since 1973 from a conservative approach to an aggressive one. In order to determine whether an aggressive approach is warranted, a retrospective multivariate analysis was carried out on 106 cases of papillary thyroid cancer. The patients have been followed for 10-28 years. Multivariate analysis was conducted following Cox's model. By this analysis, aggressive management appeared to have no impact on survival or relapse-free survival. However, age, sex, tumor size, and cervical lymphadenopathy were confirmed to be important prognostic factors in survival and/or relapse-free survival. 相似文献
54.
Double cancer of the gallbladder and common bile duct associated with anomalous junction of pancreaticobiliary ductal system. 总被引:1,自引:0,他引:1
We report a 64-year-old woman with double cancer of the gallbladder and the common bile duct associated with anomalous junction of the pancreaticobiliary ductal system. Eleven previous cases have been reported to date. From analysis of the 12 cases reviewed, including our patient, double cancer of the gallbladder and the common bile duct accompanied by anomalous junction of the pancreaticobiliary ductal system is characterized by the predominance of well-differentiated and superficial cancer. 相似文献
55.
AIM: The role of air plethysmography (APG) in the diagnosis of chronic venous insufficiency has not been well established. The purpose of this study was to elucidate the relationship between APG parameters and clinical severity in patients with chronic venous insufficiency. METHODS: Two hundred and ninety-four limbs in 154 patients with primary varicose veins were evaluated by APG. Limbs were categorized according to the clinical classification of chronic venous disease suggested by the Ad Hoc Committee on Reporting Standards in Venous Disease of the North American Chapter of the Society for Vascular Surgery and International Society for Cardiovascular Surgery (SVS/ ISCVS). RESULTS: The venous filling index (VFI) was significantly higher in classes 2, 3, 4, and 5+6 than in class 0 or 1, and did not differ among classes 2, 3, 4, 5+6. The ejection fraction did not differ significantly among the 6 classes, and the residual volume fraction was significantly higher in classes 2, 3, 5+6 than in class 0. CONCLUSIONS: APG is a reasonable method for distinguishing the presence or absence of chronic venous insufficiency, but it cannot discriminate the clinical severity. Among APG parameters, the VFI is the most useful diagnostic parameter in the evaluation of chronic venous insufficiency. 相似文献
56.
Takuya Watanabe Keiko Takahashi Tomoko Kanome Shigeki Hongo Akira Miyazaki Shinji Koba Takashi Katagiri Rajbabu Pakara Claude R Benedict 《Hypertension research》2006,29(10):821-831
Human urotensin-II (U-II) is the most potent vasoactive peptide identified to date, and may be involved in hypertension and atherosclerosis. We investigated the effects of the interactions between U-II or other vasoactive agents and mildly oxidized low-density lipoprotein (mox-LDL) or hydrogen peroxide (H2O2) on the induction of vascular smooth muscle cell (VSMC) proliferation. Growth-arrested rabbit VSMCs were incubated with vasoactive agents (U-II, endothelin-1, angiotensin-II, serotonin, or thromboxane-A2) in the presence or absence of mox-LDL or H2O2. [3H]Thymidine incorporation into DNA was measured as an index of VSMC proliferation. On interaction with mox-LDL or H2O2, U-II induced the greatest increase in [3H]thymidine incorporation among these vasoactive agents. A low concentration of U-II (10 nmol/l) enhanced the potential mitogenic effect of low concentrations of mox-LDL (120 to 337%) and H2O2 (177 to 226%). U-II at 50 nmol/l showed the maximal mitogenic effect (161%), which was abolished by G protein inactivator (GDP-beta-S), c-Src tyrosine kinase inhibitor (radicicol), protein kinase C (PKC) inhibitor (Ro31-8220), extracellular signal-regulated kinase (ERK) kinase inhibitor (PD98059), or Rho kinase inhibitor (Y27632). Mox-LDL at 5 microg/ml showed the maximal mitogenic effect (211%), which was inhibited by free radical scavenger (catalase), intracellular and extracellular antioxidants (N-acetylcysteine and probucol), nicotinamide adenine dinucleotide phosphate oxidase inhibitor (diphenylene iodonium), or c-Jun N-terminal kinase (JNK) inhibitor (SP600125). These results suggested that U-II acts in synergy with mox-LDL in inducing VSMC DNA synthesis at the highest rate among these vasoactive agents. Activation of the G protein/c-Src/PKC/ERK and Rho kinase pathways by U-II together with the redox-sensitive JNK pathway by mox-LDL may explain the synergistic interaction between these agents. 相似文献
57.
58.
Yoko Saeki Adachi Toshiko Itazawa Motokazu Nakabayashi Tatsuya Fuchizawa Yoshie Okabe Yasunori Ito Yuichi Adachi Gyokei Murakami Toshio Miyawaki 《Allergology international》2006,55(2):167-171
BACKGROUND: A new electronic mesh nebulizer, eMotion is known to have higher performance compared to conventional nebulizers. However, there are some concerns about whether too much delivered dose might cause side effects with higher frequency. METHODS: To evaluate the safety and usefulness of the nebulizer, we measured changes in heart rates and lung functions of 73 asthmatic children when they inhaled 1 microg/kg of procaterol with eMotion or a conventional nebulizer, Junior BOY. RESULTS: In 34 children with mild asthma exacerbation, physical findings, lung function and transcutaneous oxygen saturation levels were improved after inhalation using both nebulizers. No adverse effects including significant increase of heart rate were found. Improvements in the rates of the parameters were comparable. When response to beta2-agonist inhalation was checked in 39 children in stable condition, similar degrees of improvement in lung function were observed, and heart rates did not change after inhalation with either nebulizers. CONCLUSIONS: Safety and efficacy was comparable between eMotion and a conventional nebulizer when it was used to administer beta2-agonists in asthmatic children. However, from the fact that eMotion needs only 3-4 minutes to inhale 2 mL solution, eMotion could be more useful for most children who usually do not prefer longer inhalation time with conventional compressor nebulizers. 相似文献
59.
Takeshi Shinkawa Masaaki Yamagishi Keisuke Shuntoh Takako Miyazaki Takahiro Hisaoka Tomoya Inoue Hitoshi Yaku 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(11):469-471
Objective We have developed a surgical method for atrial septal defect repair through a limited right lateral thoracotomy in which the
incision line begins 2 cm caudal from the lower angle of the scapula and ends at the midaxial line, thereby improving patient
satisfaction with the cosmetic results of treatment.
Methods We performed a retrospective review of 28 patients who underwent isolated atrial septal defect repair through a limited right
lateral thoracotomy between January 2002 and August 2004. The mean age and mean body weight at the time of the operation were
85.8 months (range 9–236 months) and 23.0 kg (range 8.0–56.0 kg), respectively. All repaired defects were the ostium secundum
type.
Results There was no operative or late mortality and no late morbidity after a mean follow-up of 26 months (range 12–41 months). Echocardiography
showed no residual shunt in any of the patients. The mean length of the skin incision was 7.8 cm (range 5.0–11.0 cm), and
almost all the patients had satisfactory cosmetic results.
Conclusion The atrial septal defect repair through a limited right lateral thoracotomy in pediatric patients showed satisfactory surgical
results and excellent cosmetic results. 相似文献
60.
Tatsuya Kasai 《Nippon Ishinkin Gakkai Zasshi》2006,47(1):5-9
A statistical 30-year study of dermatomycosis in Sendai National Hospital (1968-1997) revealed many changes in the prevalent diseases: Tinea pedis and tinea unguium constantly increased during this period, and the ratio of the former associated with nail infection finally reached 30% of all tinea pedis patients. On the contrary, tinea corporis and cruris showed a remarkable decreasing tendency. Patient age distribution of each disease also showed distinctive changes, generally increasing in the older generation and decreasing in the younger. The number of patients with tinea pedis and unguium gradually increased among the middle and older generations, with the peak of the age-distribution curve shifting upward year after year. On the other hand, cases of tinea cruris among the younger generation were few in the latest years, and middle-age patients remained at a low number. In the first stage of this study the kinds of atiologic dermatophytes consisted of multiple species, but after middle period the isolation of Epidermaphyton floccosum decreased. Microsporum canis appeared first in 1976 but in the recent several years has completely disappeared. In the last few years of the period studied Trichophyton rubrum and Trichophyton mentagrophytes were the only isolates found from among all types of dermatophytoses. Infantile candidiasis remarkably increased in 1970-1975 but thereafter decreased rapidlly. Candidial intertrigo also increased in the same period but did not decrease as much thereafter and continued at the same intermediate level. The number of other types of candidiases were not greatly changed throughout the 30-year period. Malassezia infection also showed no remarkable changes, and only 20 cases of sporothrichosis were found. One case of the deep seated form of cutaneous aspergillosis was found, and this was also true of chromomycosis caused by Fonceaea pedrosoi. 相似文献