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991.
Ola Ragab Nermeen Khairy Radwa Taha Minerva Iskander 《The Egyptian Rheumatologist》2018,40(3):149-153
Aim of the work
To estimate serum level of serotonin in rheumatoid arthritis (RA) patients and study its relation with various clinical data, radiographic scores and fibromyalgia.Patients and methods
This study involved eighty RA patients divided equally according to rheumatoid factor (RF) positivity. Modified Health Assessment Questionnaire, disease activity score in 28-joints (DAS 28), visual analogue scale of pain, Short Form Health Survey for mental and physical health, fibromyalgia questionnaire, RA Articular Damage score and radiological joint damage by van der Heijde modification were assessed. Serum level for serotonin was measured for all patients.Results
The mean age of seronegative patients was 41.7 ± 10.7 years; 36 females and 4 males and of seropositive (44.9 ± 12.9 years and were 34 females and 6 males). Serum serotonin level was high in RA patients compared to control (129.8 ± 99.1 ng/ml vs 79.6 ± 54.5 ng/ml respectively, p = 0.001). Serum serotonin was higher in seropositive than seronegative (155.9 ± 93.2 vs 101.5 ± 99.4 ng/ml respectively, p = 0.007). Fibromyalgia syndrome (FMS) was associated with a significant lower serotonin level in both groups (p < 0.005). High serotonin level was associated with combined disease modifying antirheumatic drugs (p = 0.04) in seronegative patients. A lower serotonin level was associated with corticosteroids administration and dry eye (p = 0.03, p = 0.004 respectively) in seropositive cases. A significant correlation was present between serotonin level with erythrocyte sedimentation rate, vitality energy and mental health (r = 0.4, p < 0.05) in seropositive patients.Conclusion
Serum serotonin level was high in RA, especially in seropositive patients. It demonstrated central antidepressant and peripheral pro-inflammatory role. The SSRI could be of benefit only in RA with FMS. 相似文献992.
Samia Fadda Nermeen Khairy Hala Fayed Heba Mousa Radwa Taha 《The Egyptian Rheumatologist》2018,40(3):155-160
Introduction
Interstitial lung disease (ILD) represents 13% of the overall mortality in rheumatoid arthritis (RA) patients.Aim of the work
To determine the frequency and pattern of ILD among RA patients, correlate it with clinical manifestations and with anti-citrullinated peptide antibodies (ACPA) titer.Patients and methods
This study included 88 RA patients. ILD was diagnosed by high-resolution computed tomography (HRCT) and assessed by a severity score. Disease activity was assessed by clinical disease activity index (CDAI) and functional status by the modified health assessment questionnaire (MHAQ). Serum ACPA titer was assayed by ELISA.Results
The mean age of the patients was 50.15 ± 9 years, disease duration was 10.2 ± 6.2?years and they were 75 females and 13 males. ACPA was positive in 84 (95.5%). The frequency of ILD among RA patients was 71.6%. ILD patterns were: usual interstitial pneumonia (UIP) 62%, non-specific interstitial pneumonia (NSIP) 27%, others (Cryptogenic and mixed) in 11%. In RA-ILD, the mean ACPA titer was 225 ± 121.5?U/mL versus 154.3?± 121.8?U/mL in RA only. In RA-ILD, ACPA titer negatively correlated with morning stiffness, CDAI, MHAQ and six-minute walk test (r = ?0.3, p = .008, r = ?0.6, p < .0001, r = ?0.5, p < .0001 and r = ?0.5, p < .0001 respectively), while it significantly correlated with IPF severity score (r = 0.09, p < .0001) and erythrocyte sedimentation rate (ESR) (r = 0.5, p < .0001).Conclusion
ILD frequency has increased among RA patients due to improved detection by HRCT. High titer of ACPA was associated with extent and patterns of severity of ILD in RA patients. When high ACPA titer is associated with low CDAI score, physician could suspect lung involvement. 相似文献993.
Hiba S. Al-Amodi Nazik Altayeb Abdelbasit Samir H. Fatani Abdullatif Taha Babakr Maowia Mohamed Mukhtar 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):357-364
Background
Leptin levels are reported to be increased with excessive body fat and is a potential determinant of obesity and its complications. Our Objective is to evaluate the relationship between leptin levels and BMI, waist circumference and metabolic syndrome components in normal and obese females classified according to their BMI.Subjects and methods
A total of 136 female subjects aged between 20 and 60 years were recruited for the current study. Anthropometric measures included body mass index and waist circumference. The blood samples were used for estimation of plasma fasting blood glucose and serum was used for estimation of triglycerides, total cholesterol, low and high density lipoproteins, and total leptin.Results
Correlation between glucose and lipids profile with waist circumference among the whole study group (obese and non-obese) is reflecting that a strong positive correlation between BMI and blood glucose, serum TGs, cholesterol and LDL, a negative correlation was reported between BMI and serum HDL. Mean of leptin concentrations in two groups were found to be 5.77?ng/ml (±1.00) in non-obese and 28.89?ng/ml (±4.91) in the obese with metabolic syndrome. Leptin had a positive correlations with triglycerides (r?=?0.84, p?<?0.001), total cholesterol (r?=?0.77, p?<?0.001), LDL (r?=?0.83, p?<?0.001), waist circumference (r?=?0.86, p?<?0.001) and BMI (r?=?0.72, p?<?0.001) in the test group. a negative correlation was reported between BMI and serum HDL (r?=??0.48, p?<?0.001).Conclusion
Leptin levels were high in Saudi women with high BMI and waist circumference. There was a significant correlation between leptin levels and Obesity. 相似文献994.
Alper AT Sevimli S Hasdemir H Nurkalem Z Güvenç TS Akyol A Cakmak N Durmuş G Gürkan K 《Journal of thrombosis and thrombolysis》2009,27(2):130-134
A relationship exists between exposure to high altitude and increased coagulability. Mean platelet volume is a parameter of
platelet functions and may be a marker for increased platelet aggregability. The aim of this study was to compare the mean
platelet volumes and platelet counts in patients who experienced an acute coronary event at moderately high altitude and at
sea altitude. Four hundred and one patients who experienced an acute coronary event were enrolled, of them 211 were born and
had been living at the sea level, while 190 were born and had been living at high altitude (at least 2,000 m above the sea
level). Patients were compared regarding the mean platelet volumes and platelet counts. The mean platelet volumes were significantly
higher in patients living in high altitude (P = 0,001). No statistically significant differences were found among the groups regarding the platelet counts. As a result,
this increased MPV values in highlanders who experienced an acute coronary event may reflect increased platelet aggregability. 相似文献
995.
The effectiveness of ex vivo chemotherapy with drugs, such as vincristine, etoposide, and Adriamycin (doxorubicin, Adria Labs, Columbus, OH) for elimination of residual tumor cells from human bone marrow grafts could be undermined by the presence of multidrug- resistant tumor cells in the bone marrow. Therefore, to supplement chemoseparation, we investigated whether MRK-16, a monoclonal antibody (MoAb) to the surface moiety of multidrug resistance-associated P- glycoprotein antigen, can eliminate drug-resistant tumor cells in the presence of rabbit complement (RC). Two doxorubicin (DOX)-resistant human myeloma tumor cell line, 8226/DOX40 (resistant to 4 x 10(-7) mol/L DOX) and 8226/DOX6 (6 x 10(-8) mol/L DOX) with high and low amounts of cell surface P-glycoprotein, respectively, and the drug- sensitive parent cell line 8226/S were used as tumor models in this study. Using the limiting dilution assay, we have shown that three cycles of treatment with 25 micrograms/mL of MRK-16 MoAb and a 1:4 final dilution of RC eliminated 2.90 +/- 0.10 logs of 8226/DOX40 cells and 1.94 +/- 0.18 logs of 8226/DOX6 cells. One and two cycles of treatment were less effective, eliminating 0.47 +/- 0.40 and 1.94 +/- 0.36 logs of 8226/DOX40 and 0.12 +/- 0.20 and 1.63 +/- 0.58 logs of 8226/DOX6 cells, respectively. The 8226/S cell growth was unaffected by one to three cycles of treatment. The cell kill was not impaired when the antibody plus complement treatment was carried out on a mixture of 8226/DOX40 or 8226/DOX6 cells with a ninefold excess of irradiated bone marrow mononuclear cells (MNCs). The three cycles of treatment with antibody plus complement did not adversely affect granulocyte- macrophage colony-forming unit (GM-CFU) survival in hematologically normal marrows (92.5% to 104% survival) or in myeloma patient marrows (85% to 100%). These results show that it is possible to eliminate drug- resistant myeloma tumor cell lines from the admixed human bone marrow by treatment with MRK-16 MoAb plus RC. This method could prove to be effective for elimination of other drug-resistant tumor cell lines including those of leukemia and solid tumors, and will be further useful for supplementing chemopurging, and immunopurging of bone marrow with other antitumor cell antibodies. 相似文献
996.
Khalid S.A. Khabar Fahad Al-Zoghaibi Mohammed N. Al-Ahdal Tsugiya Murayama Mohammed Dhalla Naofumi Mukaida Mohammed Taha Sultan T. Al-Sedairy Yunus Siddiqui George Kessie Kouji Matsushima 《The Journal of experimental medicine》1997,186(7):1077-1085
Interferon (IFN) exhibits a potent antiviral activity in vitro and plays a major role in the early defense against viruses. Like IFN, the proinflammatory chemokine, interleukin (IL)-8, is induced by viruses and appears in circulation during viral infections. In an in vitro cytopathic effect assay for IFN, we found that IL-8 can inhibit IFN-α activity in a dose-dependent manner. This action was reversed by specific monoclonal antibodies to IL-8. The chemokine was able to attenuate the IFN-mediated inhibition of viral replication as determined by measuring infectious virus yield. IL-8 also diminished the ability of IFN to inhibit an early stage of viral replication since IL-8 attenuated the inhibition of the formation of viral proteins. It appeared that IL-8 interfered with a late rather than an early step of IFN-mediated pathway such as early gene expression. The IL-8 inhibitory action on IFN-α antiviral activity was associated with reduced 2′,5′-A oligoadenylate synthetase activity, a pathway well correlative with the anti– encephalomyocarditis virus action of IFN-α. Understanding pathways that antagonize IFN action may lead to novel approaches to potentiate endogenous and therapeutic IFN. 相似文献
997.
High rate of hepatitis C reinfection following antiviral treatment in the North East England Prisons
Rajan Bhandari Sarah Morey Abi Hamoodi Craig Thompson Dee Jones Margaret Hewett Ewan Hunter Yusri Taha Stuart McPherson 《Journal of viral hepatitis》2020,27(4):449-452
To achieve elimination of hepatitis C (HCV), a critical group to prioritise for diagnosis and treatment is the prison population, where HCV prevalence is high. A universal offer of blood‐borne virus testing (UOBBVT) programme and a new treatment pathway were introduced to seven North East England (NEE) Prisons. Our aim was to assess: (a) the proportion of individuals with active HCV commencing direct‐acting antivirals (DAAs); (b) the outcomes following DAA treatment; (3) the reinfection rate following sustained virological response (SVR). Data were collected prospectively on BBVT uptake, HCV positivity, HCV treatment outcomes and reinfection from March 2016 onwards. 8538 individuals had BBV testing. In total, 612 (7.2%) and 374 (4.4%) were HCV antibody positive and HCV RNA positive, respectively. Ultimately, 266 (71%) individuals commenced DAAs. Overall 111 achieved a documented SVR (42%), 17 (6%) failed treatment, 30 (11%) were still on treatment or had not reached 12 weeks post‐treatment at time of analysis, and 108 (41%) were lost to follow‐up. In those with a known outcome (n = 128), 87% achieved SVR. Worryingly, of those who achieved SVR, 21 (19%) were subsequently identified as having been reinfected (median time from SVR to documented reinfection 13 (range 7‐25) months). The reinfection rate was 0.406 cases per person‐year follow‐up. In conclusion, Implementation of a UOBBVT programme and new treatment pathway resulted in increased diagnosis and treatment of HCV in the NEE prison population. However, the high HCV reinfection rate suggests a need to improve harm reduction approaches. 相似文献
998.
Tarek S. Momenah Atif Alsahari Eltayeb Ahmed Khalaf Al Khalaf 《Catheterization and cardiovascular interventions》2020,95(5):1062-1065
An 11‐year‐old girl, with 25 mm mosaic tissue valve presented with clinical and echocardiographic appearance of stenotic mitral valve prosthesis. Her condition was treated via a transcatheter valve‐in‐valve implantation using a 23 mm Edwards Sapien 3, with satisfactory outcome. 相似文献
999.
Gianluca Plotino Nicola M. Grande Luca Testarelli Gianluca Gambarini Raffaella Castagnola Andrea Rossetti Taha Özyürek Massimo Cordaro Leonzio Fortunato 《Journal of endodontics》2018,44(10):1549-1552
Introduction
The aim of the present study was to investigate the impact of ambient temperature on the life span of nickel-titanium (NiTi) files.Methods
Cyclic fatigue testing of NiTi instruments was performed in a stainless steel artificial canal. During the experiment, 4 different temperatures (0°C, 20°C, 35°C, and 39°C) were used in a thermostatic bath controlled using electronic and infrared controls. Eighty R25 Reciproc Blue (VDW, Munich, Germany) and 80 R25 Reciproc (VDW) instruments were reciprocated in the artificial canal until fracture occurred, and the time to fracture and the length of the fractured fragment were recorded. The phase transformation temperature for 3 instruments of each type was analyzed by differential scanning calorimetry. One-way analysis of variance and Bonferroni tests were used to statistically analyze the data at a 5% significance level (P < .05).Results
Reciproc Blue instruments were significantly more resistant to cyclic fatigue than Reciproc at all the temperatures tested (P < .05). Fatigue resistance was proportionally higher as the environmental temperature decreased (0°C > 20°C > 35°C > 39°C). No signi?cant difference was registered for the length of the fractured fragment of both instruments tested at all temperatures tested (P > .05).Conclusions
Blue alloy significantly increases the cyclic fatigue resistance of Reciproc files compared with M-Wire alloy. Temperature significantly affects the life span of NiTi files. When the ambient temperature increases between 0°C and 35°C, the fatigue resistance of the files statistically decreases. 相似文献1000.
Tarek Abdallah Mokhtar AbdallahChadi Saifan MD Dany El SayeghMichel Chalhoub MD Louis Sasso MD 《Heart & lung : the journal of critical care》2014
Adalimumab is a fully human monoclonal anti-TNF-alpha antibody. Reported adverse effects have raised a number of safety concerns associated with their prolonged use. A case of granulomatous pneumonitis and hemidiaphragm paresis associated with adalimumab therapy for rheumatoid arthritis is described. In May 2012, a 57 year old male presented with dry cough, dyspnea and orthopnea after 4 months of treatment with adalimumab for rheumatoid arthritis. The patient received adalimumab from November 2011 to February 2012. A right hemidiaphragm elevation was shown on chest radiograph. A right hemidiaphragm paresis was shown on chest fluoroscopy. Bilateral lower lobe interstitial disease was shown on the chest HRCT scan. Open lung biopsy of the right lower lobe showed subacute granulomatous pneumonitis. In July 2013, the patient's respiratory symptoms and the previous restrictive pattern on PFTs resolved. In a same patient, a rare association of hemidiaphragm paresis and granulomatous pneumonitis with adalimumab treatment is herein reported. 相似文献