全文获取类型
收费全文 | 24571篇 |
免费 | 1816篇 |
国内免费 | 284篇 |
专业分类
耳鼻咽喉 | 263篇 |
儿科学 | 606篇 |
妇产科学 | 716篇 |
基础医学 | 3266篇 |
口腔科学 | 852篇 |
临床医学 | 2452篇 |
内科学 | 4715篇 |
皮肤病学 | 418篇 |
神经病学 | 2522篇 |
特种医学 | 759篇 |
外科学 | 3161篇 |
综合类 | 999篇 |
一般理论 | 2篇 |
预防医学 | 2038篇 |
眼科学 | 658篇 |
药学 | 1740篇 |
4篇 | |
中国医学 | 194篇 |
肿瘤学 | 1306篇 |
出版年
2023年 | 216篇 |
2022年 | 355篇 |
2021年 | 603篇 |
2020年 | 411篇 |
2019年 | 513篇 |
2018年 | 574篇 |
2017年 | 509篇 |
2016年 | 529篇 |
2015年 | 684篇 |
2014年 | 725篇 |
2013年 | 993篇 |
2012年 | 1304篇 |
2011年 | 1505篇 |
2010年 | 978篇 |
2009年 | 869篇 |
2008年 | 1267篇 |
2007年 | 1286篇 |
2006年 | 1264篇 |
2005年 | 1175篇 |
2004年 | 1095篇 |
2003年 | 1009篇 |
2002年 | 911篇 |
2001年 | 688篇 |
2000年 | 600篇 |
1999年 | 542篇 |
1998年 | 298篇 |
1997年 | 235篇 |
1996年 | 192篇 |
1995年 | 178篇 |
1994年 | 185篇 |
1993年 | 153篇 |
1992年 | 350篇 |
1991年 | 348篇 |
1990年 | 313篇 |
1989年 | 292篇 |
1988年 | 288篇 |
1987年 | 239篇 |
1986年 | 252篇 |
1985年 | 237篇 |
1984年 | 179篇 |
1983年 | 168篇 |
1982年 | 107篇 |
1979年 | 146篇 |
1978年 | 116篇 |
1977年 | 104篇 |
1975年 | 133篇 |
1974年 | 117篇 |
1973年 | 99篇 |
1972年 | 106篇 |
1971年 | 100篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Early alcoholic liver injury: Activation of lipocytes in acinar zone 3 and correlation to degree of collagen formation in the disse space 总被引:3,自引:0,他引:3
Acinar zone 3 areas in liver biopsy specimens from 23 alcoholics and 47 non-alcoholics were investigated by light microscopy and transmission electron microscopy to asses fibrosis in the perisinusoidal space and to evaluate the role of the lipocytes. Quantitative analysis by light microscopy on toluidine blue-stained sections showed a significant reduction in number of lipocytes--median values of 2.7 and 1.2 lipocytes per 100 hepatocytes in biopsies from chronic alcoholics showing no or varying degrees of zone 3 fibrosis, respectively, as compared to 3.6 lipocytes per 100 hepatocytes in non-alcoholic livers. By transmission electron microscopy, the reduction in number of lipocytes was related to a corresponding increase in number of cells rich in rough endoplasmic reticulum and microfilaments (activated lipocytes). The occurrence of activated cells was significantly correlated to fibrosis of the perisinusoidal space. Activation of lipocytes and collagenization of the perisinusoidal space appeared before light microscopic evidence of fibrosis and were topographically not related to Mallory bodies or alcoholic hepatitis. 相似文献
22.
23.
Edbert B Hsu Tamara L Thomas Eric B Bass Dianne Whyne Gabor D Kelen Gary B Green 《BMC medical education》2006,6(1):19-9
Background
Although training and education have long been accepted as integral to disaster preparedness, many currently taught practices are neither evidence-based nor standardized. The need for effective evidence-based disaster training of healthcare staff at all levels, including the development of standards and guidelines for training in the multi-disciplinary health response to major events, has been designated by the disaster response community as a high priority. We describe the application of systematic evidence-based consensus building methods to derive educational competencies and objectives in criteria-based preparedness and response relevant to all hospital healthcare workers. 相似文献24.
25.
Enrico G Caiani Eran Toledo Peter MacEneaney Keith A Collins Roberto M Lang Victor Mor-Avi 《Journal of cardiovascular magnetic resonance》2004,6(3):619-625
BACKGROUND: Cardiac magnetic resonance (MR) images are often reviewed by non-cardiologists who are not trained in the interpretation of regional left ventricular (LV) function. We hypothesized that the use of still-frame parametric MR images of wall motion could aid in the assessment of regional LV function. METHODS: Dynamic, electrocardiogram-gated, steady-state free precession (FIESTA) short-axis images were obtained in 6 to 10 slices in 18 consecutive patients. Each loop was used to automatically generate a still-frame image, in which each pixel is assigned a value equal to the amplitude of cyclic variation in local intensity, resulting in higher intensity in pixels that change between blood and tissue during the cardiac cycle. The dynamic images were reviewed by an expert cardiologist who provided gold standard grades for regional wall motion and by four radiologists. Then the radiologists reviewed and graded the same MR images in combination with parametric images. Grades assigned to each segment in the two sessions were compared with the gold standard. RESULTS: According to expert interpretation, 6 patients had normal wall motion, and 12 had wall motion abnormalities. Parametric images showed a bright band in the area spanned by endocardial motion, with reduced brightness and thickness in areas of hypokinesis. The agreement between the radiologists' grades and the gold standard significantly improved by adding parametric images (from 77% to 81%), which also resulted in reduced interobserver variability (from 52% to 33%). CONCLUSIONS: Still-frame parametric images aid in the assessment of regional wall motion by non-cardiologists who are required to interpret cardiac images. 相似文献
26.
目的观察急性冠状动脉综合征患者介入治疗后血小板活化指标CD62p、CD63及糖蛋白Ⅱb/Ⅲa受体复合物及内皮功能的改变。方法60例急性冠状动脉综合征患者在冠状动脉介入术前和术后即刻以及次日采用流式细胞仪检测血小板活化指标CD62p、CD63及糖蛋白Ⅱb/Ⅲa受体复合物;双抗体夹心固相酶联免疫吸附试验测定血浆假血友病因子的表达水平;放射免疫测定法测定血浆内皮素1表达水平;酶法测定血浆一氧化氮的含量;彩色多谱勒超声诊断仪测量内皮依赖性血管舒张功能。选择健康体检者和稳定型心绞痛患者各30例作对照,观察急性冠状动脉综合征患者冠状动脉介入前后指标的变化并与对照组比较。结果与健康对照组和稳定型心绞痛组比,急性冠状动脉综合征组CD62p、CD63及糖蛋白Ⅱb/Ⅲa受体复合物明显增高(P<0.05或0.01);急性冠状动脉综合征患者介入术后即刻CD62p、CD63和糖蛋白Ⅱb/Ⅲa受体复合物与术前相比明显增高(P<0.01),但术后24h较术前无明显变化(P>0.05)。与健康对照组和稳定型心绞痛组比,急性冠状动脉综合征组假血友病因子、内皮素1的表达水平明显增高(P<0.01),内皮依赖性血管舒张功能和一氧化氮降低(P<0.05或<0.01);急性冠状动脉综合征患者介入术后即刻血浆假血友病因子和内皮素1水平升高(P<0.05或P<0.01),内皮依赖性血管舒张功能和一氧化氮水平降低(P<0.05),且介入术后24h假血友病因子水平也较术前升高(P<0.05),内皮依赖性血管舒张功能降低(P<0.05),但内皮素1和一氧化氮水平与术前差异无显著性(P>0.05)。结论血小板活化和内皮功能的损伤在急性冠状动脉综合征发生和发展过程中起重要的作用,冠状动脉介入术后血管内皮受到一定损伤,血小板有一定程度的激活。 相似文献
27.
Ophira Salomon Joseph Moisseiev Tamara Vilganski Rima Dardik Shimon Kurtz Eva Shpringer David M Steinberg Nurit Rosenberg 《Blood coagulation & fibrinolysis》2006,17(6):485-488
To determine whether polymorphisms of platelet surface glycoprotein associated with arterial thrombosis are risk factors for branch retinal vein occlusion. A case-control study in which 69 patients with branch retinal vein occlusion and 147 controls who attended the eye clinic for nonvascular complications participated. DNA was extracted from whole blood and analyzed for genotyping of platelet glycoprotein polymorphisms by polymerase chain reactions and specific restricted enzymes. No relationship was found between the four platelet glycoprotein polymorphisms i.e. GPIa C807T, VNTR and Kozak of glycoprotein Ibalpha, the HPA-1 of glycoprotein IIIa and the occurrence of branch retinal vein occlusion. The HPA-2 polymorphism was found in 18 out 60 (30%) patients with branch retinal vein occlusion in comparison with 27 out 142 (19%) of controls, with an estimated odds ratio of 1.8 (95% confidence interval, 0.91-3.65). The four platelet glycoprotein polymorphisms are not risk factors for branch retinal vein occlusion and therefore it seems unnecessary to screen those patients for it. A larger study is required, however, to determine whether HPA-2 is a novel risk factor for branch retinal vein occlusion. 相似文献
28.
K H Orend N Zarbis H Schelzig G Halter G Lang L Sunder-Plassmann 《European journal of vascular and endovascular surgery》2007,34(6):666-672
OBJECTIVES: To present a single centers' 7-year experience in the endovascular treatment of acute traumatic lesions of the descending thoracic aorta (ATL of the DTA). MATERIALS & METHODS: Between March 1999 and December 2006, 34 consecutive acute traumatic lesions of the descending aorta (23 men, mean age 44 years) were treated endovascularly. Stentgrafts used were TAG Excluder, Zenith TX2 and Talent. In 23 patients the Left Subclavian Artery (LSA) was covered. Mean procedural duration was 20 to 75 minutes. RESULTS: Exclusion of the rupture site was achieved in all cases with no conversion to open surgery. Overall 30-day mortality was 8.8%. Two patients died on post operative day (pod) 1 and one on pod 22 from cranial injuries. No death or neurological deficit related to the endovascular treatment was reported. Four type I endoleaks required treatment either by balloon reexpansion (n=2) or by additional stentgraft implantation (n=2). In two patients the stentgraft collapsed totally several days postoperatively. Two patients required secondary surgical procedures (iliac access complication and revascularisation of the left subclavian artery n=1). The average follow-up was 43.8 months (1-93 months). No stentgraft related abnormality has been subsequently documented. CONCLUSIONS: The endovascular treatment of ATL of the DTA may offer the best means of therapy in a polytrauma patient. 相似文献
29.
[目的]探讨外固定支架结合骨折端局部注射自体骨髓多能干细胞治疗桡骨远端粉碎性骨折的有效性。[方法]应用外固定支架结合骨折端局部注射自体骨髓多能干细胞治疗桡骨远端粉碎性骨折18例。[结果]随访6~15个月(平均8个月),优10例,良6例,可2例,差0例。优良率为88.9%。没有一例出现针道浅表感染等并发症。[结论]外固定支架结合骨折端局部注射自体骨髓多能干细胞是治疗桡骨远端粉碎性骨折的一种方便、有效的方法,不仅骨折愈合效果满意,而且固定确实可靠,并能早期功能调整和训练。 相似文献
30.
体外短波热疗联合前列腺灸及哈乐治疗非细菌性前列腺炎和前列腺痛疗效观察 总被引:5,自引:1,他引:4
目的 探讨慢性非细菌性前列腺炎(CNP)和前列腺痛(PD)的治疗方法。方法 应用体外短波热疗联合前列腺灸及α1A-肾上腺素能受体阻滞剂哈乐治疗CNP和PD患者26例,疗程8周。观察治疗前后前列腺炎症状评分(CPSI)与最大尿流率(MFR)变化。结果 有效率为80.8%。治疗前后CPSI和MFR均有显著改善(P〈0.05)。结论 体外短波热疗联合前列腺灸及哈乐治疗CNP和PD安全有效。 相似文献