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991.
Histopathological analysis of cold snare polypectomy and its indication for colorectal polyps 10–14 mm in diameter
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992.
993.
Hiroyuki Takamatsu Takeshi Yamashita Takeharu Kotani Aiko Sawazaki Hirokazu Okumura Shinji Nakao 《International journal of hematology》2010,91(5):903-906
A 79-year-old female patient with multiple myeloma who had no prior cardiac disease history developed an acute myocardial
infarction on day 5 after receiving bortezomib and dexamethasone (BD). After treatment of coronary stenoses by stents, she
received another course of BD therapy and developed angina pectoris on day 5 after the therapy. Bortezomib’s antitumor effect
is due to the inhibition of proteasome activity. This inhibition may increase endothelial progenitor cell apoptosis and decrease
endothelial nitric oxide synthase/nitric oxide (eNOS/NO), thus leading to coronary spasm. It is, therefore, important to carefully
monitor patients being treated with bortezomib for the potential occurrence of ischemic heart disease. 相似文献
994.
995.
Takeshi Matsumoto Nobuaki Ando Tomoko Tomii Kentaro Uesugi 《Calcified tissue international》2011,88(1):54-62
Little is known about hypoxia-induced modification of the canal network in the cortical bone despite its involvement in intracortical
vascularity and bone blood supply. In this study, we examined the effect of chronic hypoxia on the canal network in postnatal
bone. Tibiae were harvested from 4- and 8-week-old rats (hyp-4 and -8, n = 8 each), whose growth was retarded owing to postnatal exposure to hypoxia (12–14% O2), and from 3- and 4-week-old normoxic rats (cnt-4 and -5, n = 8 each), which were similar in tibial length and cortical cross-sectional area to hyp-4 and -8, respectively. The diaphyseal
canals were detected by monochromatic synchrotron radiation CT with a 3.1-μm voxel resolution. The anatomical properties of
the canal network were compared between age- or size-matched hypoxic and normoxic groups. The canals were larger in diameter,
were more densely distributed and connected, and opened into the marrow cavity with a higher density in hyp-4 than in cnt-4.
The canal density and connectivity were also higher in hyp-4 than in cnt-3. The canal diameter, density, and connectivity
were smaller in hyp-8 than in cnt-4; however, the densities of endocortical and periosteal canal openings did not differ between
hyp-8 and cnt-4. We concluded that chronic hypoxia enhanced the formation of cortical canal networks at the postnatal developmental
stage, probably facilitating intra- and transcortical vascularization and bone perfusion accordingly. 相似文献
996.
997.
Asako Kawaguchi Kyosuke Kanai Yukio Satoh Chizu Touge Keiko Nagata Takeshi Sairenji Yoshitsugu Inoue 《Virus genes》2009,38(2):215-223
To study variations of Epstein-Barr virus (EBV), we analyzed the gp350/220 gene for several cell lines and Japanese wild isolates
using direct sequencing. The N-terminal region was highly conserved in all EBVs except for Jijoye/P3HR-1 and a few isolates.
The variation of the region coincided with EBV types A and B (also referred to as types 1 and 2) and were, respectively, designated
as the types a and b. The type A/a was detected in most Japanese cell lines and wild isolates, and was classified as China1
type with latent membrane protein (LMP) 1 gene. The type B/b was detected in only a few wild isolates with the Med and China2
types. The C-terminus had more diversity than the N-terminus and lacked the divergence between types A/a and B/b. The phylogenetic
analyses of the gp350/220 and LMP1 genes may suggest a mode of EBV evolution into types A/a and B/b and then to LMP1 subtypes. 相似文献
998.
999.