全文获取类型
收费全文 | 2517篇 |
免费 | 155篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 81篇 |
妇产科学 | 15篇 |
基础医学 | 404篇 |
口腔科学 | 46篇 |
临床医学 | 154篇 |
内科学 | 581篇 |
皮肤病学 | 53篇 |
神经病学 | 248篇 |
特种医学 | 107篇 |
外科学 | 539篇 |
综合类 | 6篇 |
预防医学 | 52篇 |
眼科学 | 15篇 |
药学 | 130篇 |
中国医学 | 2篇 |
肿瘤学 | 253篇 |
出版年
2023年 | 17篇 |
2022年 | 26篇 |
2021年 | 54篇 |
2020年 | 29篇 |
2019年 | 58篇 |
2018年 | 53篇 |
2017年 | 37篇 |
2016年 | 51篇 |
2015年 | 51篇 |
2014年 | 66篇 |
2013年 | 92篇 |
2012年 | 137篇 |
2011年 | 145篇 |
2010年 | 85篇 |
2009年 | 82篇 |
2008年 | 147篇 |
2007年 | 150篇 |
2006年 | 152篇 |
2005年 | 189篇 |
2004年 | 146篇 |
2003年 | 167篇 |
2002年 | 152篇 |
2001年 | 26篇 |
2000年 | 32篇 |
1999年 | 31篇 |
1998年 | 58篇 |
1997年 | 49篇 |
1996年 | 30篇 |
1995年 | 27篇 |
1994年 | 20篇 |
1993年 | 34篇 |
1992年 | 27篇 |
1991年 | 22篇 |
1990年 | 23篇 |
1989年 | 21篇 |
1988年 | 15篇 |
1987年 | 15篇 |
1986年 | 13篇 |
1985年 | 7篇 |
1984年 | 21篇 |
1983年 | 15篇 |
1982年 | 11篇 |
1981年 | 11篇 |
1979年 | 13篇 |
1978年 | 11篇 |
1977年 | 12篇 |
1975年 | 6篇 |
1973年 | 7篇 |
1972年 | 9篇 |
1970年 | 8篇 |
排序方式: 共有2700条查询结果,搜索用时 15 毫秒
51.
Tanimoto TE Yamaguchi T Tanaka Y Saito A Tajima K Karasuno T Kasai M Kishi K Mori T Maseki N Morishima S Miyakoshi S Kasai M Ohno Y Kim SW Numata A Kami M Takaue Y Mori S Harada M 《British journal of haematology》2004,125(4):480-493
A reduced incidence of graft versus host disease (GvHD) has been documented among Japanese allogeneic bone marrow transplantation (BMT) patients, as the Japanese are genetically more homogeneous than western populations. To clarify whether this ethnic difference affects the results of allogeneic peripheral blood stem cell transplantation (PBSCT), we conducted a nationwide survey to compare clinical outcomes of allogeneic PBSCT (n = 214) and BMT (n = 295) from a human leucocyte antigen-identical-related donor in Japanese patients. The cumulative incidence of grades II-IV acute GvHD was 37.4% for PBSCT and 32.0% for BMT. The cumulative incidence of extensive chronic GvHD at 1 year was significantly higher after PBSCT than BMT (42% vs. 27%; P < 0.01). The organ involvement patterns of GvHD were different between the two groups. By multivariate analyses, the incidence of chronic GvHD was significantly increased in PBSCT, whereas the stem cell source did not affect the incidence of acute GvHD, transplant-related mortality, relapse or survival. We concluded that Japanese PBSCT patients have an increased risk of chronic GvHD compared with BMT patients, but the incidence of acute GvHD was still lower than in western populations. Thus, the choice of haematopoietic stem cell source should be considered based on data for individual ethnic populations. 相似文献
52.
53.
54.
Matsushita T Ishida S Oketani N Ichiki H Ninomiya Y Hamasaki S Tei C 《The American journal of cardiology》2008,102(2):197-202
Although advancement of succeeding atrial activation by a ventricular extrastimulus (VES) on His refractoriness during supraventricular tachycardia (SVT) has been used as evidence of an accessory pathway (AP), the sensitivity of this method is suboptimal. This study was designed to compare the His-His (H-H) and atrial-atrial (A-A) intervals of the first entrained cycle during ventricular overdrive pacing (VOD) for the diagnosis of AP, in comparison to the conventional VES method. In 55 patients with SVT, a VES was elicited on His refractoriness during SVT. VOD was subsequently performed at cycle lengths 30 to 40 ms shorter than SVT cycle lengths. When the A-A interval became equal to the pacing cycle length after some beats of VOD, the cycle was considered the first entrained cycle and the H-H interval preceding the A-A interval was measured. VES advanced the next atrial activation in 16 patients (52%) with an AP, but in no patient without an AP. The H-H interval of the first entrained cycle was longer than the pacing cycle length by > or =15 ms in all patients with an AP, but was equal to the pacing cycle length in all patients without an AP. The criterion of H-H greater than A-A by > or =15 ms for the first entrained cycle provided higher diagnostic yield for AP compared with the VES method(100% vs 52%, p <0.001). In conclusion, this new criterion reliably diagnoses the presence of an AP in patients with SVT, with higher sensitivity compared with the VES method. 相似文献
55.
56.
Vascular surgery using argatroban in a patient with a history of heparin-induced thrombocytopenia. 总被引:1,自引:0,他引:1
Yoshiyuki Tokuda Masahiko Matsumoto Takaaki Sugita Junichiro Nishizawa Katsuhiko Matsuyama Kazunori Yoshida Takehiko Matsuo 《Circulation journal》2003,67(10):889-890
For patients with a history of heparin-induced thrombocytopenia (HIT) who undergo cardiac or vascular surgery, the optimal anticoagulation substitute for heparin has yet to be established. Recombinant hirudin has been recommended; however, this agent is unsuitable for patients with renal dysfunction. Argatroban was used in the present patient who had a history of HIT and renal dysfunction and required peripheral vascular surgery. Argatroban was easy to monitor and control, regardless of renal function, and has advantages over other anticoagulants for such patients. 相似文献
57.
Intracontinental and intercontinental dissemination of Asian H5 highly pathogenic avian influenza virus (clade 2.3.4.4) in the winter of 2014–2015
下载免费PDF全文
![点击此处可从《Reviews in medical virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Takehiko Saito Taichiro Tanikawa Yuko Uchida Nobuhiro Takemae Katsushi Kanehira Ryota Tsunekuni 《Reviews in medical virology》2015,25(6):388-405
Asian H5 highly pathogenic avian influenza viruses (HPAIVs) that possess the clade 2.3.4.4 HA gene have been identified in wild birds and poultry since late 2014 in both Europe and North America (N. America). Clade 2.3.4.4 H5 HPAIVs of the H5N8 subtype have been isolated in both regions, whereas reassortment viruses with NA N1 and N2 subtypes of the North American (N. American). avian lineage have only been identified in N. America. The HA genes of those isolates were closely related to genes of the HPAIVs that have caused massive outbreaks in poultry in Korea since January 2014. The outbreaks caused by those viruses and the genetic relatedness of their HA and NA genes are reviewed in this study. Although the illegal movement of poultry and poultry products cannot be ruled out as a cause of intercontinental and intracontinental dissemination of clade 2.3.4.4 H5 HPAIVs during the winter of 2014–2015, transmission of the viruses by infected migratory birds appears to be a more plausible mechanism for their dissemination. In particular, the involvement of migratory birds in HPAIV transmission between Asia and N. America is highly likely because of the reassortments between H5N8 HPAIV and the N. American lineage avian influenza viruses. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
58.
Four types of Ipsilateral Breast Tumor Recurrence (IBTR) after breast‐conserving surgery: Classification of IBTR based on precise pathological examination
下载免费PDF全文
![点击此处可从《Pathology international》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Takehiko Sakai Seiichiro Nishimura Akiko Ogiya Masahiko Tanabe Kiyomi Kimura Hidetomo Morizono Kotaro Iijima Yumi Miyagi Masujiro Makita Yoshinori Ito Masahiko Oguchi Rie Horii Futoshi Akiyama Takuji Iwase 《Pathology international》2015,65(3):113-118
We classified ipsilateral breast tumor recurrences (IBTRs) based on strict pathological rules. Ninety‐six women who were surgically treated for IBTR were included. IBTRs were classified according to their origins and were distinguished based on strict pathological rules: relationship between the IBTR and the primary lumpectomy scar, surgical margin status of the primary cancer, and the presence of in situ lesions of IBTR. The prognosis of these subgroups were compared to that of new primary tumors (NP) in the narrow sense (NPn) that occurred far from the scar. Distant‐disease free survival of IBTR that occurred close to the scar with in situ lesions and a negative surgical margin of the primary cancer (NP occurred close to the scar, NPcs) was similar to that of NPn. In contrast, IBTR that occurred close to the scar without in situ lesions (true recurrence (TR) that arose from residual invasive carcinoma foci, TRinv) had significantly poorer prognosis than NPn. IBTR that occurred close to the scar with in situ lesions and a positive surgical margin of the primary cancer (TR arising from a residual in situ lesion, TRis) had more late recurrences than NPcs. Precise pathological examinations indicated four distinct IBTR subtypes with different characteristics. 相似文献
59.
Takahiro Shoji Takehiko Tarui Takashi Igarashi Yuki Mochida Hiroyuki Morinaga Yasuhiko Miyakuni Yoshitaka Inoue Yasuhiko Kaita Hiroshi Miyauchi Yoshihiro Yamaguchi 《The Journal of emergency medicine》2018,54(4):410-418
Background
Bleeding from hemorrhagic shock can be immediately controlled by blocking the proximal part of the hemorrhagic point using either resuscitative thoracotomy for aortic cross-clamping or insertion of a large-caliber (10–14Fr) resuscitative endovascular balloon occlusion of the aorta (REBOA) device via the femoral artery. However, such methods are very invasive and have various complications. With recent progress in endovascular treatment, a low-profile REBOA device (7Fr) has been developed.Objective
The objective of this study was to report our experience of this low-profile REBOA device and to evaluate the usefulness of emergency physician?operated REBOA in life-threatening hemorrhagic shock.Methods
Ten patients with refractory hemorrhagic shock underwent REBOA using this device via the femoral artery. All REBOA procedures were performed by emergency physicians. The success rate of the insertion, vital signs, and REBOA-related complications were evaluated.Results
Median age was 54 years (interquartile range 33–78 years). The causes of hemorrhagic shock were trauma (n = 4; 1 blunt and 3 penetrating), ruptured abdominal aortic aneurysm (n = 3), and obstetric hemorrhage (n = 3). Two patients had cardiopulmonary arrest upon arrival. REBOA procedure was successful in all patients, and all became hemodynamically stable to undergo definitive interventions after REBOA. There were no REBOA-related complications. The mortality rate within 24 h and 30 days was 40%.Conclusions
This REBOA device was useful for emergency physicians in life-threatening hemorrhagic shock because of its ease in handling and low invasiveness. 相似文献60.