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991.
Sekine Masayuki Enomoto Takayuki Watanabe Yoh Katabuchi Hidetaka Yaegashi Nobuo Aoki Daisuke 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(11):2123-2129
International Journal of Clinical Oncology - Despite being widely used, to date (June 2021), the regimen of bevacizumab 10 mg/kg every 2 weeks (Q2W) combined with chemotherapy is... 相似文献
992.
Taniguchi Hiroya Masuishi Toshiki Kawazoe Akihito Muro Kei Kadowaki Shigenori Bando Hideaki Iino Shuichi Kageyama Rie Yoshino Takayuki 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(11):2017-2024
International Journal of Clinical Oncology - Napabucasin is an oral NAD(P)H:quinone oxidoreductase 1 bioactivatable agent that generates reactive oxygen species, is hypothesised to affect multiple... 相似文献
993.
994.
995.
Ukawa Y Izumi Y Ohbuchi T Takahashi T Ikemizu S Kojima Y 《Journal of nutritional science and vitaminology》2007,53(3):293-296
We examined whether the extract from Hatakeshimeji (Lyophyllum decastes, LD) mushrooms suppresses the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of LD extract to NC/Nga mice inhibited the development of AD-like skin lesions based on lower total skin severity scores and serum immunoglobulin E (IgE) levels. Splenic lymphocytes were stimulated with the T cell mitogen concanavalin A, and secretion of a Th1 cytokine (IFN-gamma) and a Th2 cytokine (IL-4) was determined by ELISA. IFN-gamma production was not inhibited by treatment with LD extract. On the other hand, IL-4 production was significantly decreased by treatment with LD extract. These results suggest that LD extract exerts anti-allergic actions by suppressing the serum IgE and Th2-type immune responses. 相似文献
996.
Yuta Hagiwara Tomohide Yoshie Takahiro Shimizu Hana Ogura Takayuki Fukano Tatsuro Takada Toshihiro Ueda Yasuhiro Hasegawa 《Journal of Medical Ultrasonics》2017,44(2):207-210
Contrast-enhanced transoral carotid ultrasonography (CETOCU) is a novel examination modality that is superior to other modalities in the cases of pseudo-occlusion with severe arteriosclerotic stenosis of the distal internal carotid artery (ICA), and is also useful for noninvasively evaluating changes over time in the vessel distal to the stent following carotid artery stenting (CAS). We report a case of a patient who we evaluated with CETOCU for a pseudo-occlusive ICA before and after CAS. 相似文献
997.
Takayuki Ogura Alan Kawarai Lefor Mitsunobu Nakamura Kenji Fujizuka Kousuke Shiroto Minoru Nakano 《The Journal of emergency medicine》2017,52(5):715-722
Background
In trauma resuscitation with resuscitative endovascular balloon occlusion of the aorta (REBOA), urgent and accurate placement of the catheter in the resuscitation area without fluoroscopy can shorten the time from admission to REBOA, allowing rapid, temporary control of bleeding.Discussion
The experience-based protocol in our center for ultrasound-guided REBOA in the resuscitation area without fluoroscopy is as follows: the femoral artery is punctured and a guidewire inserted; sonography is used to verify that the guidewire is in the abdominal aorta; the position of the balloon is confirmed with ultrasound after estimating the distance to the clavicle, and the pressure in the radial artery and sheath is used to monitor correct positioning; connect the pressure transducer to the catheter sheath for continuous monitoring of the blood pressure in the sheath, and inflate the balloon until the blood pressure tracing at the sheath has disappeared; check the pulse in the left radial artery, and withdraw the catheter slightly if the pulse in the radial artery is not palpable or is decreased (if this pulse is not palpable or decreased, the balloon is in the aortic arch). In this retrospective review of our REBOA protocol, between April 2012 and March 2016, 34 patients were enrolled. Two patients had complications, including dissection of the femoral artery in one and difficult percutaneous vascular access in another. Median time needed to complete the procedure was 8 min. Overall, 24 of 34 patients survived more than 24 h (72%), and overall mortality was 47%. Patients who lived more than 24 h, and then died had severe traumatic brain injury or septic shock.Conclusions
Ultrasound-guided REBOA is presented. Monitoring the blood pressure in the left radial artery allows us to determine adequate positioning of the balloon, and the blood pressure in the catheter sheath located in the femoral artery should also be monitored to prevent aortic injuries caused by the overinflation of the balloon. 相似文献998.
Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin 总被引:1,自引:1,他引:1
Kettawan A Takahashi T Kongkachuichai R Charoenkiatkul S Kishi T Okamoto T 《Journal of Clinical Biochemistry and Nutrition》2007,40(3):194-202
The effects of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase), on oxidative stress resistance and the protective effects of coenzyme Q (CoQ) were investigated. When simvastatin was administered orally to mice, the levels of oxidized and reduced CoQ(9) and CoQ(10) in serum, liver, and heart, decreased significantly when compared to those of control. The levels of thiobarbituric acid reactive substances induced by Fe(2+)-ascorbate in liver and heart mitochondria also increased significantly with simvastatin. Furthermore, cultured cardiac myocytes treated with simvastatin exhibited less resistance to oxidative stress, decreased time to the cessation of spontaneous beating in response to H(2)O(2) addition, and decreased responsiveness to electrical field stimulation. These results suggested that oral administration of simvastatin suppresses the biosynthesis of CoQ, which shares the same biosynthesis pathway as cholesterol up to farnesyl pyrophosphate, thus compromising the physiological function of reduced CoQ, which possesses antioxidant activity. However, these undesirable effects induced by simvastatin were alleviated by coadministering CoQ(10) with simvastatin to mice. Simvastatin also reduced the activity of NADPH-CoQ reductase, a biological enzyme that converts oxidized CoQ to the corresponding reduced CoQ, while CoQ(10) administration improved it. These findings may also support the efficacy of coadministering CoQ(10) with statins. 相似文献
999.
Yuji Kamijo Yoko Kaneko Toru Ichikawa Nobuhiko Kobayashi Takayuki Koyama Tetsuji Kakegawa Hiroshi Kamijo Keiichi Kono Satoshi Minami Naoki Tanaka Hideo Arakura Masayuki Hirata Makoto Higuchi Kendo Kiyosawa Kazuhiko Hora 《Therapeutic apheresis》2002,6(6):459-462
Our report discusses a 29 year old female patient with nephrotic syndrome due to lupus nephritis, biopsy-proven World Health Organization classification Types IVb and V that was controlled with low-density lipoprotein (LDL) apheresis. She was initially treated with steroid therapy, including methylprednisolone pulse therapy, and the serological activity of her systemic lupus erythematosus was suppressed. However, her nephrotic state, accompanied by severe hyperlipidemia, persisted despite the steroid therapy. Since we could not obtain her consent to administer immunosuppressants such as cyclophosphamide, we tried to treat her using LDL apheresis (LDL-A). We found that her urine protein excretion, hyperlipidemia, hypoalbuminemia, and renal function improved following the initiation of LDL-A. This suggests that LDL-A may be an effective therapy for nephrotic syndrome due to lupus nephritis through short-term amelioration of hyperlipidemia. 相似文献
1000.
Carotid artery ultrasound and intravascular ultrasound 总被引:5,自引:0,他引:5
Lipid lowering therapy is associated with a significant reduction in cardiocerebral events. But, additional studies are necessary to identify patients in whom atheroma may results in developing coronary events. Intravascular ultrasound(IVUS) and carotid artery echocardiography have significantly contributed to the understanding of nature of atherosclerosis and have validated the concepts of vascular remodeling and vulnerable plaque. Actually, intimal-medial thickness(IMT) in carotid echo is good predictors of cardiovascular events. Positive remodeled plaque with soft characteristics is more likely to rupture and cause acute coronary syndrome. Thus, studies using IVUS and carotid echo may lead to important insights into how risk factor reduction stabilizes plaque and reduces the risk of acute coronary events. 相似文献