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排序方式: 共有624条查询结果,搜索用时 62 毫秒
621.
Maryam Golmohammadi Dalia Ahmed Elmaghraby Andrés Alexis Ramírez-Coronel Nodir Rakhimov Shahad Saad Mohammed Rosario Mireya Romero-Parra Mohammed Abed Jawad Mohammad Yasin Zamanian Afsaneh Soltani Niloofar Taheri Farzaneh Kianifar Nasim Vousooghi 《Fundamental & clinical pharmacology》2023,37(5):900-909
Bladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anticancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anticancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU-87 cells, reduces the expression of p-P70S6K, and induces apoptosis by p-AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC. 相似文献
622.
Afsaneh Sadeghzadeh Bazargan MD Mahsa Shemshadi MD Elham Ziaeifar MD Amirmasoud Taheri MD Masoumeh Roohaninasab MD Azadeh Goodarzi MD Mahta Mirhashemi MD 《Journal of Cosmetic Dermatology》2023,22(9):2548-2552
Background
Tranexamic acid is used to treat pigmented disorder in dermatology for a long time however there are limited data for effectiveness of tranexamic acid for rejuvenation and improvement of wrinkle. Here we want to find the effectiveness of tranexamic acid as mesotherapy in improvement of periorbital wrinkle in a clinical trial study.Methods
Patients with melasma who were treated with 4 session of tranexamic acid mesotherapy at intervals on 1 week were evaluated with Visioface device before starting and 1 month after last course of treatment. The outcomes including volume, area, area percent, and depth were measured by Visioface device.Results
Mean of periorbital wrinkles volume before and after procedure were 89 271 and 74 639 pixel3 (px3), respectively. Very significant difference with p-value of <0.001 was detected at volume of patient wrinkles before and after treatment. Moreover, the mean of area (and area percent) of their periorbital wrinkles before and after therapeutic method were 8481 Px3 (1.131%) and 7184 Px3 (0.646%), respectively, with significant differences (both have p-value of <0.001).Mean of periorbital wrinkles depth at before and after treatment were 9.8 and 9.6, respectively, without remarkable difference (p-value was 0.257).Conclusion
Tranexamic acid mesotherapy significantly leads to reduced volume and area of wrinkles. Injection of tranexamic acid as mesotherapy seems to be effective in improvement of periorbital wrinkling. 相似文献623.
Ashwini G. Naik Robert V. Kenyon Aynaz Taheri Tanya Y. BergerWolf Baher A. Ibrahim Yoshitaka Shinagawa Daniel A. Llano 《Journal of neuroscience research》2023,101(2):217-231
Understanding functional correlations between the activities of neuron populations is vital for the analysis of neuronal networks. Analyzing large-scale neuroimaging data obtained from hundreds of neurons simultaneously poses significant visualization challenges. We developed V-NeuroStack, a novel network visualization tool to visualize data obtained using calcium imaging of spontaneous activity of neurons in a mouse brain slice as well as in vivo using two-photon imaging. V-NeuroStack creates 3D time stacks by stacking 2D time frames for a time-series dataset. It provides a web interface to explore and analyze data using both 3D and 2D visualization techniques. Previous attempts to analyze such data have been limited by the tools available to visualize large numbers of correlated activity traces. V-NeuroStack's 3D view is used to explore patterns in dynamic large-scale correlations between neurons over time. The 2D view is used to examine any timestep of interest in greater detail. Furthermore, a dual-line graph provides the ability to explore the raw and first-derivative values of activity from an individual or a functional cluster of neurons. V-NeuroStack can scale to datasets with at least a few thousand temporal snapshots. It can potentially support future advancements in in vitro and in vivo data capturing techniques to bring forth novel hypotheses by allowing unambiguous visualization of massive patterns in neuronal activity data. 相似文献
624.
Afsaneh Sadeghzadeh Bazargan MD Elham Ziaeifar MD Abolfazl Abouie MD Sadegh Mirahmadi MD Amirmasoud Taheri Mehdi Gheisari 《Journal of Cosmetic Dermatology》2023,22(10):2714-2720