全文获取类型
收费全文 | 10258篇 |
免费 | 427篇 |
国内免费 | 74篇 |
专业分类
耳鼻咽喉 | 208篇 |
儿科学 | 290篇 |
妇产科学 | 119篇 |
基础医学 | 1536篇 |
口腔科学 | 176篇 |
临床医学 | 556篇 |
内科学 | 2638篇 |
皮肤病学 | 179篇 |
神经病学 | 677篇 |
特种医学 | 444篇 |
外科学 | 1682篇 |
综合类 | 43篇 |
一般理论 | 2篇 |
预防医学 | 185篇 |
眼科学 | 127篇 |
药学 | 632篇 |
中国医学 | 26篇 |
肿瘤学 | 1239篇 |
出版年
2023年 | 58篇 |
2022年 | 121篇 |
2021年 | 254篇 |
2020年 | 126篇 |
2019年 | 164篇 |
2018年 | 212篇 |
2017年 | 175篇 |
2016年 | 201篇 |
2015年 | 188篇 |
2014年 | 275篇 |
2013年 | 365篇 |
2012年 | 572篇 |
2011年 | 671篇 |
2010年 | 387篇 |
2009年 | 289篇 |
2008年 | 495篇 |
2007年 | 585篇 |
2006年 | 592篇 |
2005年 | 615篇 |
2004年 | 651篇 |
2003年 | 604篇 |
2002年 | 685篇 |
2001年 | 188篇 |
2000年 | 142篇 |
1999年 | 159篇 |
1998年 | 156篇 |
1997年 | 145篇 |
1996年 | 127篇 |
1995年 | 94篇 |
1994年 | 113篇 |
1993年 | 109篇 |
1992年 | 104篇 |
1991年 | 96篇 |
1990年 | 95篇 |
1989年 | 95篇 |
1988年 | 89篇 |
1987年 | 70篇 |
1986年 | 78篇 |
1985年 | 63篇 |
1984年 | 62篇 |
1983年 | 44篇 |
1982年 | 40篇 |
1981年 | 31篇 |
1980年 | 33篇 |
1979年 | 30篇 |
1978年 | 37篇 |
1974年 | 28篇 |
1973年 | 26篇 |
1972年 | 29篇 |
1971年 | 29篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
A new operative procedure was devised to treat polysyndactyly of the fifth toe. This procedure, which consists of removal of the fifth toe, correction of the alignment of the preserved sixth toe by arthroplasty and construction of an interdigital space by Z-plasty, is technically simple and produces good results, both functionally and aesthetically. 相似文献
32.
A case-control study of breast cancer among Japanese women: with special reference to family history and reproductive and dietary factors 总被引:8,自引:0,他引:8
Dr. Ikuko Kato Dr. Shigeto Miura Fijio Kasumi Takuji Iwase Hideya Tashiro Yoshihiro Fujita Hiroki Koyama Tadashi Ikeda Kiyoshi Fujiwara Keiichi Saotome Kazuaki Asaishi Rikiya Abe Mitsuhiro Nihei Tsunehiro Ishida Takao Yokoe Hiroshi Yamamoto Motoi Murata 《Breast cancer research and treatment》1992,24(1):51-59
Summary To study the effects of family history and reproductive, anthropometric, and dietary factors on the risk of breast cancer among low risk populations, we conducted a hospital-based case-control study involving 908 patients with breast cancer and their matched controls, in Japan. A positive family history of breast cancer significantly increased the risk of breast cancer (odds ratio = 1.52, 95% confidence interval: 1.14–2.03). The risk further increased with increasing number of family members affected. Obesity, single marital status, fewer births, a late childbirth, and less consumption of green-yellow vegetables and dairy products were also associated with an increased risk of breast cancer. These associations were independent in multivariate analyses. There was no increase in risk associated with consumption of high fat foods. When analyzed by menopausal status, the association with family history of breast cancer, especially in the first degree of relatives, was more evident for premenopausal breast cancer. The associations with obesity and lower consumption of dairy products were more pronounced for postmenopausal breast cancer, while those with lower parity and single marital status were stronger for premenopausal breast cancer. 相似文献
33.
Hanako Tsubone Tomoyuki Onishi Tetsuyuki Hayashibara Shizuo Sobue Takashi Ooshima 《Journal of oral pathology & medicine》2002,31(4):239-241
A Japanese girl was referred to Osaka University Dental Hospital for examination of a tooth-like structure that had erupted following spontaneous exfoliation of a natal tooth in the lower left primary central incisor region. The structure had erupted at 6 months of age, and radiographic and clinical examination showed composition of pulp and dentin, but no enamel. On histological examination, the majority of the dentin area had a tubular dentin-like appearance, while the outer area of the root appeared to be composed of an osteodentin-like substance. Most of the dentin was covered by cementum. These findings suggest that the structure had originated from a developing remnant of the extracted natal tooth, which must have remained in the gingival tissues. We termed this calcified structure a residual natal tooth. 相似文献
34.
Hiroshi Yano Masahiro Murakami Yoshiaki Nakano Takeshi Tono Tadashi Ohnishi Takashi Iwazawa Yutaka Kimura Toshiyuki Kanoh Takushi Monden 《Digestive endoscopy》2004,16(4):343-346
We performed laparoscopic appendectomy and drainage to treat panperitonitis due to perforated appendicitis that occurred in a 28‐year‐old woman. We believe this is an appropriate procedure to treat perforated appendicitis because it is safe and minimally invasive, and faster recovery can be expected than after conventional open appendectomy. 相似文献
35.
Y. Saitoh N. Arita T. Hayakawa T. Onishi M. Koga S. Mori and H. Mogami 《Andrologia》1990,22(6):519-524
In order to investigate whether a hypothalamic disorder cause hypogonadism in male prolactinomas, LH pulsatile secretion was studied in 13 male patients. Serum PRL levels ranged from 186 to 45,000 ng ml-1 before treatment, and all the tumors were macroadenomas. Reduced LH secretion was revealed in 5 of 13 patients, and FSH was reduced in 1 of 13. Serum testosterone (T) levels were lower than the normal limit in all the patients. HCG tests in 3 patients showed good responses, but the peak values of T were lower than those of normal men. LH pulsatilities were examined in 5 hyperprolactinemic patients before treatment, in 4 hyperprolactinemic patients after operation, and in 8 normoprolactinemic patients after operation and/or bromocriptine treatment. There was no significant difference of the mean LH values, the frequencies of LH pulses, and amplitudes among the hyperprolactinemic patients before operation (n = 5), the normoprolactinemic patients after operation (n = 8), and normal men (n = 7). From these results, it was evident that the hypothalamus and pituitary function of male prolactinomas were well preserved, in spite of higher serum PRL levels and larger tumor size than those reported in females. It is suggested that the main cause of hypogonadism in these patients is due to testicular dysfunction resulting from excessive serum PRL. 相似文献
36.
Fibrate for treatment of primary biliary cirrhosis 总被引:1,自引:0,他引:1
Shinji Iwasaki Naoaki Akisawa Toshiji Saibara Saburo Onishi 《Hepatology research》2007,37(S3):S515-S517
Recent studies of the effectiveness of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cirrhosis (PBC) reported that UDCA therapy did not necessarily stop the progression of liver fibrosis in all patients, even those with early stage PBC. Thus, there is a need for more effective treatments that could prevent asymptomatic PBC from progressing to the icteric stage. Bezafibrate is effective in approximately two-thirds of non-icteric patients who have not shown a complete response to UDCA. Serum bilirubin, aspartate aminotransferase and γ-guanosine 5'-triphosphate levelswere significantly lower in patients who responded to additional bezafibrate on univariate analysis. The putative mechanism by which bezafibrate acts in cholestasis is by increasing phospholipid output into bile, which forms micelles with the hydrophobic bile acid that reduces its toxicity. 相似文献
37.
Tadashi Nomura MD ; Hiroto Terashi MD PhD ; Makoto Omori MD ; Atsushi Sakurai MD ; Takeru Sunagawa PhD ; Masumi Hasegawa MS ; Shinya Tahara MD PhD 《Wound repair and regeneration》2007,15(6):833-837
Hypertrophic scars (HS) are a consequence of abnormal wound healing. We examined fatty acids that are contained within, and participate in, every reaction through the membrane; then, we analyzed the percentage composition of the fatty acids in deepithelialized normal dermis (ND) and HS. In vivo HS samples were obtained from six patients undergoing surgical excision, and ND samples from five patients undergoing skin grafting surgery for excess. In vitro, cultured fibroblasts from HS and ND were also analyzed. The percentage composition of fatty acids extracted from all the samples was analyzed. In vivo, arachidonic acid (20:4) was significantly more abundant in HS than in ND, in the phospholipids from both whole tissue and cell membranes. In vitro, there were no significant differences among ND, HS, and 10% fetal calf serum. The results suggest that HS formation does not necessarily involve simple excess of 20:4; however, there are considerable differences in the percentage composition of 20:4 between ND and HS. Arachidonic acid probably participates in the formation and maintenance of HS, whereas in vitro cultured fibroblasts are affected largely by fetal calf serum. 相似文献
38.
Mitsuru Masaki Tadashi Kuroda Naoki Hosen Hisao Hirota Kazuo Terai Yuichi Oshima Yoshikazu Nakaoka Shoko Sugiyama Ryusuke Kimura Satoshi Yoshihara Manabu Kawakami Norishige Iizuka Yasuhiko Tomita Hiroyasu Ogawa Ichiro Kawase Keiko Yamauchi-Takihara 《Journal of the American Society of Echocardiography》2004,17(4):397-398
A 57-year-old man with a history of renal cell carcinoma presented with presyncope. He underwent nephrectomy years earlier followed by HLA-matched allogeneic peripheral-blood stem-cell transplantation. Echocardiographic investigation revealed a solitary right ventricle mass without contiguous vena caval or right atrial involvement. The mass was pathologically confirmed to be metastatic carcinoma in the right ventricular cavity. This case highlights the need to consider an underlying neoplastic syndrome in patients presenting isolated right ventricle mass by echocardiography. 相似文献
39.
40.
Osamu Mori Minoru Miyasato Tadashi Karashima Takashi Hashimoto 《The Journal of dermatology》1998,25(8):497-502
Previous studies using primary monolayer cultures of epithelial cells from the involved epidermis of patients with mammary and extramammary Paget's disease investigated whether Paget cells proliferate as other malignant cells do. Although epithelial monolayers from the involved skin were maintained for approximately 45 days, no permanent cell lines were established. The proportion of carcinoembryonic antigen (CEA)-positive cells did not increase in the long-term cultures. Herein, we report studies of whether there is a real reduction of Paget cell numbers or if this is merely a decrease in the expression of CEA by the cells. Furthermore, we investigated whether Paget cells survive longer when cultured free from any potential inhibitory keratinocytes or other epidermal cells. Skin samples were obtained from one patient with mammary Paget's disease and three with extramammary Paget's disease; epidermal cells were cultured in vitro. An enrichment of Paget cells was carried out from the cultured epidermal cells by combining an anti-epithelial membrane antigen monoclonal antibody, binding to immunobeads, and density gradient centrifugation in Nycodenz. The separated cells were re-cultured in Keratinocyte-SFM serum-free media. The proportion of CEA-positive cells did not increase in the cultures, and the purified cells did not show any increase in survival times compared to the non-purified cultured cells. These results suggest that the decrease of CEA-positive cells noted during culture results from a decline in expression of CEA in the Paget cells. Paget cells in the involved epidermis do not proliferate significantly and thus differ from many other malignant cells. 相似文献